Skip to main content
SpringerLink
Log in

Decreased bone mineral density in adult familial Mediterranean fever patients: a pilot study

  • Brief Report
  • Published:
Clinical Rheumatology Aims and scope Submit manuscript

Abstract

We investigated the association between familial Mediterranean fever (FMF) and osteoporosis (OP) in adult patients. Thirty-five attack-free FMF patients (28 females, 7 males; mean age 36.9 ± 5.7 years) were individually matched to control subjects on the basis of age (within 2 years) and sex. All patients were taking regular colchicine. Subjects having any condition that can cause decreased bone mineral density (BMD) were excluded from the study. BMD was measured at the spine and femur by dual X-ray absorptiometry (DXA). Data was given as the median (IQR). T scores of the spine were −0.700 (−1.097 to −0.262) and −0.450 (−0.830 to 0.112) in FMF patients and healthy controls, respectively (p > 0.05). T scores of the femur neck were −0.900 (−1.480 to −0.570) and −0.430 (−1.472 to 0.247) in FMF patients and healthy controls, respectively (p > 0.05). Total femur T scores were significantly lower in FMF patients than healthy controls (−0.780 [−1.222 to −0.085] vs. −0.100 [−0.765 to 0.537], respectively, p = 0.021). Total femur T scores were significantly decreased in adult patients with FMF. Ongoing subclinical inflammation may be associated with decreased bone mineral content in those patients.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Ozen S (2003) Familial Mediterranean fever: revisiting an ancient disease. Eur J Pediatr 162:449–454

    Article  PubMed  Google Scholar 

  2. Orbach H, Ben-Chetrit E (2001) Familial Mediterranean fever A review and update. Minerva Med 92:421–430

    PubMed  CAS  Google Scholar 

  3. Ben-Chetrit E, Levy M (1998) Familial Mediterranean fever. Lancet 351:659–664

    Article  PubMed  CAS  Google Scholar 

  4. Korkmaz C, Ozdogan H, Kasapcopur O et al (2002) Acute phase response in familial Mediterranean fever. Ann Rheum Dis 61:79–81

    Article  PubMed  CAS  Google Scholar 

  5. Köklü S, Öztürk MA, Balcı M et al (2005) Interferon-gamma levels in familial Mediterranean fever. Jt Bone Spine 72:38–40

    Article  Google Scholar 

  6. Baykal Y, Saglam K, Yilmaz MI et al (2003) Serum sIL-2r, IL-6, IL-10 and TNF-a level in familial Mediterranean fever patients. Clin Rheumatol 22:99–101

    Article  PubMed  CAS  Google Scholar 

  7. Bagci S, Toy B, Tuzun A et al (2004) Continuity of cytokine activation in patients with familial Mediterranean fever. Clin Rheumatol 23:333–337

    Article  PubMed  Google Scholar 

  8. Haznedaroglu S, Oztürk MA, Sancak B et al (2005) Serum interleukin 17 and interleukin 18 levels in familial Mediterranean fever. Clin Exp Rheumatol 23:77–80

    Google Scholar 

  9. Tunca M, Kirkali G, Soytürk M et al (1999) Acute phase response and evolution of familial Mediterranean fever. Lancet 353:1415

    Article  PubMed  CAS  Google Scholar 

  10. Ginaldi L, Di Benedetto MC, De Martinis M (2005) Osteoporosis, inflammation and ageing. Immun Ageing 2:14

    Article  PubMed  Google Scholar 

  11. Kearns AE, Khosla S, Kostenuik P (2008) Receptor activator of nuclear factor kappaB ligand and osteoprotegerin regulation of bone remodeling in health and disease. Endocr Rev 29:155–192

    Article  PubMed  CAS  Google Scholar 

  12. Duzova A, Ozaltin F, Ozon A et al (2004) Bone mineral density in children with familial Mediterranean fever. Clin Rheumatol 23:230–234

    Article  PubMed  Google Scholar 

  13. Derk CT (2006) Osteoporosis in premenopause. Postgrad Med 119:8–15

    Article  PubMed  Google Scholar 

  14. Raisz LG (1999) Physiology and pathophysiology of bone remodeling. Clin Chem 45:1353–1358

    PubMed  CAS  Google Scholar 

  15. Miller PD (2006) Guidelines for the diagnosis of osteoporosis: T-scores vs fractures. Rev Endocr Metab Disord 7:75–89

    Article  PubMed  Google Scholar 

  16. Clowes JA, Riggs BL, Khosla S (2005) The role of immune system in the pathophsiology of osteoporosis. Immunol Rev 208:207–227

    Article  PubMed  CAS  Google Scholar 

  17. McClung M (2007) Role of RANKL inhibition in osteoporosis. Arthritis Res Ther 9(Suppl 1):1–3

    Article  CAS  Google Scholar 

  18. Tanaka S, Nakamura K, Takahasi N et al (2005) Role of RANKL in physiological and pathological bone resorption and therapeutics targeting the RANKL–RANK signaling system. Immunol Rev 208:30–49

    Article  PubMed  CAS  Google Scholar 

  19. Romas E, Gillespie T, Martin TJ (2002) Involvement of receptor activator of NFKB ligand and tumor necrosis factor-a in bone destruction in rheumatoid arthritis. Bone 30:340–346

    Article  PubMed  CAS  Google Scholar 

  20. Tang BM, Eslick GD, Nowson C et al (2007) Use of calcium or calcium in combination with vitamin D supplementation to prevent fractures and bone loss in people aged 50 years and older: a meta-analysis. Lancet 370:657–666

    Article  PubMed  CAS  Google Scholar 

  21. Kessenich CR (2007) Nonpharmacological prevention of osteoporotic fractures. Clin Interv Aging 2:263–266

    PubMed  Google Scholar 

  22. Deprez X, Fardellone P (2003) Nonpharmacological prevention of osteoporotic fractures. Jt Bone Spine 70:448–457

    Article  Google Scholar 

Download references

Acknowledgement

This study was supported by Gazi University Scientific Research Project Foundation.

Disclosures

None.

Author information

Authors and Affiliations

  1. Department of Internal Medicine, Faculty of Medicine, Gazi University, Ankara, TR-06500, Turkey

    Elif Suyani & Serpil Muge Deger

  2. Department of Rheumatology, Faculty of Medicine, Gazi University, Ankara, Turkey

    Mehmet Akif Ozturk, Mehmet D. Demirag, Berna Goker & Seminur Haznedaroglu

Authors
  1. Elif Suyani
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mehmet Akif Ozturk
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Serpil Muge Deger
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Mehmet D. Demirag
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Berna Goker
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Seminur Haznedaroglu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Elif Suyani.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Suyani, E., Ozturk, M.A., Deger, S.M. et al. Decreased bone mineral density in adult familial Mediterranean fever patients: a pilot study. Clin Rheumatol 27, 1171–1175 (2008). https://doi.org/10.1007/s10067-008-0930-0

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10067-008-0930-0

Keywords

Search

Navigation