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The role of mannose-binding lectin in systemic lupus erythematosus

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Abstract

Susceptibility to systemic lupus erythematosus (SLE) is associated with genetic, hormonal, immunological, and environmental factors. Many genes have been related with the appearance of SLE, including several loci that code different complement components and their receptors. Some genetic deficiencies of complement molecules are strongly associated with SLE, probably because these deficiencies could cause decreased clearance of apoptotic cell material. As a consequence of the apoptotic material accumulation, high levels of autoantigens can be presented inappropriately to the immune system in an inflammatory context, resulting in an imbalance on the mechanisms of immunological tolerance, immune system activation, and autoantibody production. Recent studies proposed a role to the mannose-binding lectin (MBL) in the SLE physiopathogenesis. This protein activates the complement system, and the presence of several polymorphisms at the promoter and coding regions of the MBL-2 gene determines alterations at the plasma levels of MBL. Some of these polymorphisms have been associated with SLE susceptibility, as well as with clinical and laboratory typical features of this disease, cardiovascular events, and infections. Besides, it has been described that the presence of anti-MBL autoantibodies in sera of SLE patients can influence MBL plasma levels and its functional activity.

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Authors and Affiliations

  1. Division of Rheumatology, Department of Internal Medicine, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

    Odirlei André Monticielo, Tamara Mucenic, Ricardo Machado Xavier & João Carlos Tavares Brenol

  2. Department of Genetics, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

    José Artur Bogo Chies

  3. Serviço de Reumatologia do Hospital de Clínicas de Porto Alegre—HCPA, Rua Ramiro Barcelos, 2350—Largo Eduardo Zaccaro Faraco, Sala 645, 6° andar, Porto Alegre, Rio Grande do Sul, 90035-903, Brazil

    Odirlei André Monticielo

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  1. Odirlei André Monticielo
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  2. Tamara Mucenic
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  3. Ricardo Machado Xavier
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  4. João Carlos Tavares Brenol
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  5. José Artur Bogo Chies
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Correspondence to Odirlei André Monticielo.

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Monticielo, O.A., Mucenic, T., Xavier, R.M. et al. The role of mannose-binding lectin in systemic lupus erythematosus. Clin Rheumatol 27, 413–419 (2008). https://doi.org/10.1007/s10067-008-0838-8

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  • DOI: https://doi.org/10.1007/s10067-008-0838-8

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