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Polymorphism of interleukin-10 promoter and tumor necrosis factor receptor II in Vietnamese patients with systemic lupus erythematosus

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Abstract

The polymorphism of the interleukin-10 (IL-10) promoter and tumor necrosis factor receptor II (TNFRII) in Vietnamese patients with systemic lupus erythematosus (SLE) was examined by using the polymerase chain reaction (PCR) method with genomic DNA and allele-specific primers. In the frequency of IL-10 promoter 1082 genotypes consisting of AA, A/G and GG, the allele frequency of G in the SLE patients was significantly higher than that in the healthy controls. On the other hand, there was no statistical difference in the frequency of TNF receptor (TNFR) II 196 genotypes between the SLE patients and healthy controls. It was therefore suggested that the polymorphism of the IL-10 promoter, but not TNFRII, might participate in the pathogenesis of SLE in Vietnamese.

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Abbreviations

IL-10:

Interleukin-10

PCR:

Polymerase chain reaction

SLE:

Systemic lupus erythematosus

SNPs:

Single nucleotide polymorphisms

TNFR:

Tumor necrosis factor receptor

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Acknowledgements

We would like to thank Dr. Ta Thi Men for her assistance in DNA extraction.

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Authors and Affiliations

  1. Department of Microbiology and Immunology, Aichi Medical University School of Medicine, 480-1195, Nagakute, Aichi, Japan

    Pham Dang Khoa, Tsuyoshi Sugiyama & Takashi Yokochi

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  1. Pham Dang Khoa
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  2. Tsuyoshi Sugiyama
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  3. Takashi Yokochi
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Correspondence to Takashi Yokochi.

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Khoa, P.D., Sugiyama, T. & Yokochi, T. Polymorphism of interleukin-10 promoter and tumor necrosis factor receptor II in Vietnamese patients with systemic lupus erythematosus. Clin Rheumatol 24, 11–13 (2005). https://doi.org/10.1007/s10067-004-0952-1

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  • DOI: https://doi.org/10.1007/s10067-004-0952-1

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