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Biology of glioma cancer stem cells

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Molecules and Cells

Abstract

Gliomas, much like other cancers, are composed of a heterogeneous mix of neoplastic and non-neoplastic cells that include both native and recruited cells. There is extensive diversity among the tumor cells, with differing capacity for in vitro and in vivo growth, a property intimately linked to the cell’s differentiation status. Those cells that are undifferentiated, self-renewing, with the capacity for developing tumors (tumorigenic) cells are designated by some as cancer stem cells, because of the stem-like properties. These cells may be a critical therapeutic target. However the exact identity and cell(s) of origin of the so-called glioma cancer stem cell remain elusive. Here we review the current understanding of glioma cancer stem cell biology.

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  1. University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA

    Deric M. Park

  2. Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA

    Deric M. Park

  3. Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA

    Deric M. Park

  4. Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic, Cleveland, OH, USA

    Jeremy N. Rich

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Park, D.M., Rich, J.N. Biology of glioma cancer stem cells. Mol Cells 28, 7–12 (2009). https://doi.org/10.1007/s10059-009-0111-2

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