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Association of dopamine D4 receptor (DRD4) exon III repeat polymorphism with temperament in 3-year-old infants

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Abstract

The long forms of the dopamine D4 receptor (DRD4) exon III repeat polymorphism (L-DRD4) have been linked in some studies to the adult personality trait of novelty seeking (NS), as well as to infant personality traits related to interest and activity. The current investigation extends the results of our previous longitudinal study on 1- to 5-month-old neonates assessed by the Early and Revised Infancy Temperament Questionnaire (EITQ/RITQ), in which we found a significant correlation between the DRD4 polymorphism and the adaptability trait at 1 month of age. In this study, we examined the relationship between children′s behavior at 3 years of age, measured with the Toddler Temperament Scale (TTS), and DRD4 exon III repeat polymorphism. We found a significant association between the behavioral dimension of intensity of reaction and DRD4 genotypes. Current data failed to confirm the association with the adaptability trait. None of the extraversion and/or exploratory behavior measures was related to the L-DRD4 allele, as expected. In contrast, children with 4/7 genotypes showed worse response to new stimuli compared with 4/4 genotypes. This study corroborates only in part previous results on the link between the DRD4 gene and human temperament.

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Acknowledgements

This work was supported by a grant from the Italian Ministry of Health.

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Authors and Affiliations

  1. IRCCS-CSS, San Giovanni Rotondo and CSS-Mendel Institute, Rome, Italy

    Alessandro De Luca, Anna Buccino & Bruno Dallapiccola

  2. Facoltà di Scienze della Formazione, Università di Urbino, Urbino, Italy

    Mario Rizzardi & Nando Filograsso

  3. Istituto di Pediatria Preventiva e Neonatologia, Università di Bologna, Bologna, Italy

    Rosina Alessandroni & Gian Paolo Salvioli

  4. Dipartimento di Biopatologia e Diagnostica per Immagini, Università di Roma Tor Vergata, Rome, Italy

    Giuseppe Novelli

  5. Dipartimento di Medicina Sperimentale e Patologia, Università di Roma La Sapienza, Rome, Italy

    Bruno Dallapiccola

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  1. Alessandro De Luca
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  2. Mario Rizzardi
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  3. Anna Buccino
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  8. Bruno Dallapiccola
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Correspondence to Bruno Dallapiccola.

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De Luca, A., Rizzardi, M., Buccino, A. et al. Association of dopamine D4 receptor (DRD4) exon III repeat polymorphism with temperament in 3-year-old infants. Neurogenetics 4, 207–212 (2003). https://doi.org/10.1007/s10048-003-0146-z

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  • DOI: https://doi.org/10.1007/s10048-003-0146-z

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