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Tissue engineering and cell-based therapy toward integrated strategy with artificial organs

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Abstract

Research in order that artificial organs can supplement or completely replace the functions of impaired or damaged tissues and internal organs has been underway for many years. The recent clinical development of implantable left ventricular assist devices has revolutionized the treatment of patients with heart failure. The emerging field of regenerative medicine, which uses human cells and tissues to regenerate internal organs, is now advancing from basic and clinical research to clinical application. In this review, we focus on the novel biomaterials, i.e., fusion protein, and approaches such as three-dimensional and whole-organ tissue engineering. We also compare induced pluripotent stem cells, directly reprogrammed cardiomyocytes, and somatic stem cells for cell source of future cell-based therapy. Integrated strategy of artificial organ and tissue engineering/regenerative medicine should give rise to a new era of medical treatment to organ failure.

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Authors and Affiliations

  1. Department of Therapeutic Strategy for Heart Failure, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-8655, Japan

    Satoshi Gojo

  2. Research Team for Vascular Medicine, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan

    Masashi Toyoda

  3. Department of Reproductive Biology, National Institute for Child Health and Development, 2-10-1, Okura, Setagaya, Tokyo, 157-8535, Japan

    Akihiro Umezawa

Authors
  1. Satoshi Gojo
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  2. Masashi Toyoda
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  3. Akihiro Umezawa
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Corresponding authors

Correspondence to Satoshi Gojo or Akihiro Umezawa.

Additional information

This article is a translation of an article that appeared in The Japanese Journal of Artificial Organs 2010;39:202–207.

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Gojo, S., Toyoda, M. & Umezawa, A. Tissue engineering and cell-based therapy toward integrated strategy with artificial organs. J Artif Organs 14, 171–177 (2011). https://doi.org/10.1007/s10047-011-0578-4

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  • DOI: https://doi.org/10.1007/s10047-011-0578-4

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