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The effect of the type of intraperitoneally implanted prosthetic mesh on the systemic inflammatory response

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Abstract

Background

The purpose of this study was to determine any differences in the systemic inflammatory response after the intraperitoneal implantation of three different types of polypropylene mesh.

Methods

Thirty-two male New Zealand rabbits underwent a 6-cm midline incision and opening of the peritoneal cavity. The animals were randomly divided into four groups. In groups A, B, and C, there was an intraperitoneal placement of polypropylene mesh, titanium-coated polypropylene mesh, and composite polypropylene/e-PTFE mesh, respectively. Group D received a sham operation. Blood was sampled preoperatively and at 6, 24, 48, and 168 h postoperatively to measure white blood cell count (WBC), tumor necrosis factor-alpha (TNF-α), and malondialdehyde (MDA).

Results

Statistically significant elevations of WBC, TNF-α and MDA were observed in all four groups at 6, 24, and 48 h postoperatively (P < 0.05). There were no statistically significant differences in WBC, TNF-α, and MDA between groups A, B, and C at any time interval. However, a statistically significant elevation of WBC (P < 0.05) and TNF-α (P < 0.05) was observed between each of the groups with mesh implantation and group D at 24 h postoperatively.

Conclusion

Intraperitoneal mesh implantation induces mild systemic inflammatory response regardless of the type of implanted mesh.

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Authors and Affiliations

  1. 2nd Surgical Department, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece

    G. Chatzimavroudis, I. Koutelidakis, B. Papaziogas, S. Atmatzidis & K. Atmatzidis

  2. 4th Department of Internal Medicine, Medical School, University of Athens, Athens, Greece

    T. Tsaganos, P. Koutoukas & E. Giamarellos-Bourboulis

  3. Kampouridou 19, Panorama, Thessaloniki, 55236, Greece

    G. Chatzimavroudis

Authors
  1. G. Chatzimavroudis
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  2. I. Koutelidakis
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  3. B. Papaziogas
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Correspondence to G. Chatzimavroudis.

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Chatzimavroudis, G., Koutelidakis, I., Papaziogas, B. et al. The effect of the type of intraperitoneally implanted prosthetic mesh on the systemic inflammatory response. Hernia 12, 277–283 (2008). https://doi.org/10.1007/s10029-007-0327-z

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  • DOI: https://doi.org/10.1007/s10029-007-0327-z

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