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Gastrointestinal Polyposis in Childhood: Clinicopathologic and Genetic Features

  • Perspectives in Pediatric Pathology
  • Published:
Pediatric and Developmental Pathology

Abstract

Gastrointestinal polyps and certain extraintestinal lesions in children may herald a hereditary polyposis syndrome, with an increased risk of neoplasia and other health problems for both children and their relatives. The availability of molecular/genetic screening tests has increased early diagnosis of younger members of known polyposis families. This article reviews the gross and microscopic features of polyposis syndromes of childhood and summarizes the molecular/genetic advances in this field. Clinical management is also briefly discussed.

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ACKNOWLEDGMENTS

Portions of the text, tables, and figures in this article are an updated version of a previous article (from Coffin and Pappin [171], with permission of S. Karger AG, Basel). We thank Samantha Farr and Krista Spilker for manuscript preparation.

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Authors and Affiliations

  1. Department of Pathology, University of Utah Health Sciences Center, 30 N. 1900 E, Salt Lake City, UT 84132-2501, USA

    Amy Lowichik & Cheryl M. Coffin

  2. Department of Pathology, Primary Children’s Medical Center, 100 North Medical Drive, Salt Lake City, UT 84113-1100, USA

    Amy Lowichik & Cheryl M. Coffin

  3. Department of Pediatrics, University of Utah School of Medicine, 30 N. 1900 E, Salt Lake City, UT 84132-2501, USA

    W. Daniel Jackson

  4. Division of Pediatric Gastroenterology/Nutrition, Primary Children’s Medical Center, 100 North Medical Drive, Salt Lake City, UT 84113-1100, USA

    W. Daniel Jackson

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Correspondence to Amy Lowichik.

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Lowichik, A., Jackson, W. & Coffin, C. Gastrointestinal Polyposis in Childhood: Clinicopathologic and Genetic Features . Pediatr. Dev. Pathol. 6, 371–391 (2003). https://doi.org/10.1007/s10024-002-0701-x

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