Abstract
Various diseases should be considered when evaluating a suprasellar mass. Diabetes insipidus has been reported as the primary manifestation in a patient with Langerhans cell histiocytosis involving the hypothalamopituitary axis (HPA) and can be helpful for the diagnosis. The use of endoscopic biopsy for suprasellar masses has increased. However, as it is difficult to make a diagnosis with endoscopic biopsy because of the many artifacts, pathologists must be careful. Langerhans cell histiocytosis involving the HPA as solitary lesions is rare. We report the eighth case that provides neurologists, radiologists, and pathologists with various implications.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Lichtenstein L (1953) Histiocytosis X: integration of eosinophilic granuloma of bone, Letterer–Siwe disease, and Schuller–Christian disease as related manifestations of a single nosologic entity. AMA Arch Pathol 56:84–102
Nezelof C, Basset F, Rousseau MF (1973) Histiocytosis X histogenetic arguments for a Langerhans cell origin. Biomedicine 18:365–371
Arico M, Egeler RM (1998) Clinical aspects of Langerhans cell histiocytosis. Hematol Oncol Clin N Am 12:247–258
Broadbent V, Dunger DB, Yeomans E, Kendall B (1993) Anterior pituitary function and computed tomography/magnetic resonance imaging in patients with Langerhans cell histiocytosis and diabetes insipidus. Med Pediatr Oncol 21:649–654
Grois N, Fahrner B, Arceci RJ et al (2010) Central nervous system disease in Langerhans cell histiocytosis. J Pediatr 156:873–881
Bernstrand C, Sandstedt B, Ahstrom L, Henter JI (2005) Long-term follow-up of Langerhans cell histiocytosis: 39 years’ experience at a single centre. Acta Paediatr 94:1073–1084
Donadieu J, Rolon MA, Thomas C et al (2004) Endocrine involvement in pediatric-onset Langerhans’ cell histiocytosis: a population-based study. J Pediatr 144:344–350
Grois N, Potschger U, Prosch H et al (2006) Risk factors for diabetes insipidus in Langerhans cell histiocytosis. Pediatr Blood Cancer 46:228–233
Haupt R, Nanduri V, Calevo MG et al (2004) Permanent consequences in Langerhans cell histiocytosis patients: a pilot study from the Histiocyte Society–Late Effects Study Group. Pediatr Blood Cancer 42:438–444
Nanduri VR, Bareille P, Pritchard J, Stanhope R (2000) Growth and endocrine disorders in multisystem Langerhans’ cell histiocytosis. Clin Endocrinol (Oxf) 53:509–515
Grois N, Flucher-Wolfram B, Heitger A, Mostbeck GH, Hofmann J, Gadner H (1995) Diabetes insipidus in Langerhans cell histiocytosis: results from the DAL-HX 83 study. Med Pediatr Oncol 24:248–256
Brown CW, Jarvis JG, Letts M, Carpenter B (2005) Treatment and outcome of vertebral Langerhans cell histiocytosis at the Children’s Hospital of Eastern Ontario. Can J Surg 48:230–236
Cochrane LA, Prince M, Clarke K (2003) Langerhans’ cell histiocytosis in the paediatric population: presentation and treatment of head and neck manifestations. J Otolaryngol 32:33–37
Schmitz L, Favara BE (1998) Nosology and pathology of Langerhans cell histiocytosis. Hematol Oncol Clin N Am 12:221–246
Dhall G, Finlay JL, Dunkel IJ et al (2008) Analysis of outcome for patients with mass lesions of the central nervous system due to Langerhans cell histiocytosis treated with 2-chlorodeoxyadenosine. Pediatr Blood Cancer 50:72–79
Broadbent V, Pritchard J (1997) Diabetes insipidus associated with Langerhans cell histiocytosis: is it reversible? Med Pediatr Oncol 28:289–293
Minehan KJ, Chen MG, Zimmerman D, Su JQ, Colby TV, Shaw EG (1992) Radiation therapy for diabetes insipidus caused by Langerhans cell histiocytosis. Int J Radiat Oncol Biol Phys 23:519–524
Rosenzweig KE, Arceci RJ, Tarbell NJ (1997) Diabetes insipidus secondary to Langerhans’ cell histiocytosis: is radiation therapy indicated? Med Pediatr Oncol 29:36–40
Asano T, Goto Y, Kida S, Ohno K, Hirakawa K (1999) Isolated histiocytosis X of the pituitary stalk. J Neuroradiol 26:277–280
Beers GJ, Manson J, Carter AP, Bell R (1986) Intracranial histiocytosis X: a case report. J Comput Tomogr 10:237–241
Horn EM, Coons SW, Spetzler RF, Rekate HL (2006) Isolated Langerhans cell histiocytosis of the infundibulum presenting with fulminant diabetes insipidus. Childs Nerv Syst 22:542–544
Isoo A, Ueki K, Ishida T et al (2000) Langerhans cell histiocytosis limited to the pituitary-hypothalamic axis: two case reports. Neurol Med Chir (Tokyo) 40:532–535
O’Sullivan RM, Sheehan M, Poskitt KJ, Graeb DA, Chu AC, Joplin GF (1991) Langerhans cell histiocytosis of hypothalamus and optic chiasm: CT and MR studies. J Comput Assist Tomogr 15:52–55
Scholz M, Firsching R, Feiden W, Breining H, Brechtelsbauer D, Harders A (1995) Gagel’s granuloma (localized Langerhans cell histiocytosis) in the pituitary stalk. Clin Neurol Neurosurg 97:164–166
Acknowledgment
This study was supported by a National Research Foundation of Korea grant (2010-0021092) funded by the Korean government (MEST) and a grant from the National R&D Program for Cancer Control under the Ministry of Health, Welfare, and Family Affairs (no. 0520300).
Conflict of interest
The authors declare no conflict of interest.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Noh, S., Kim, DS., Kim, J. et al. Langerhans cell histiocytosis in endoscopic biopsy: marked pinching artifacts by endoscopy. Brain Tumor Pathol 28, 285–289 (2011). https://doi.org/10.1007/s10014-011-0034-4
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10014-011-0034-4