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Consecutive histological changes in an astroblastoma that disseminated to the spinal cord after repeated intracranial recurrences: a case report

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Abstract

A 17-year-old male patient underwent surgery five times (four consecutive intracranial tumor removal surgeries and a final spinal tumor removal surgery). After the third surgery, this case was reported as a low-grade astroblastoma that is characterized by perivascular pseudorosettes consisting of elongated tumor cells arranged around the blood vessels. However, the fourth and fifth surgical specimens demonstrated very interesting histological changes in the astroblastoma. Through the course of relapses, the constituent cells of the astroblastic perivascular rosettes became smaller and rounder, and a multilayered cell arrangement was observed. The nucleus-to-cytoplasm ratio increased, and the compact intervascular cells ultimately lost glial fibrillary acidic protein (GFAP) expression. These undifferentiated cells showed high MIB-1 indices and an increased olig2 index. On the other hand, the cells in all the surgical specimens were positive for certain neuronal markers such as NSE, TUJ1, and nestin. Some astroblastomas may be more immature than the usual astrocytes; however, it is necessary to study more cases to confirm this.

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References

  1. Bailey P, Cushing H (1926) Classification of the tumours of the glioma group on a histogenetic basis with a correlated study of prognosis. Lippincott, Montreal

    Google Scholar 

  2. Kaji M, Takeshima H, Nakazato Y, et al (2006) Low-grade astroblastoma recurring with extensive invasion. Neurol Med-Chir 46:450–454

    Article  Google Scholar 

  3. Bannykh SI, Fan X, Black KL (2007) Malignant astroblastoma with rhabdoid morphology. J Neuro-Oncol 83:277–278

    Article  Google Scholar 

  4. Alaraj A, Chan M, Oh S, et al (2007) Astroblastoma presenting with intracerebral hemorrhage misdiagnosed as dural arteriovenous fistula: review of a rare entity. Surg Neurol 67:308–313

    Article  PubMed  Google Scholar 

  5. Bell JW, Osborn AG, Salzman KL, et al (2007) Neuroradiologic characteristics of astroblastoma. Neuroradiology 49:203–209

    Article  PubMed  Google Scholar 

  6. Yunten N, Ersahin Y, Demirtas E, et al (1996) Cerebral astroblastoma resembling an extra-axial neoplasm. J Neuroradiol 23:38–40

    PubMed  CAS  Google Scholar 

  7. Baka JJ, Patel SC, Roebuck JR, et al (1993) Predominantly extraaxial astroblastoma: imaging and proton MR spectroscopy features. AJNR 14:946–950

    PubMed  CAS  Google Scholar 

  8. Kubota T, Sato K, Arishima H, et al (2006) Astroblastoma: immunohistochemical and ultrastructural study of distinctive epithelial and probable tanycytic differentiation. Neuropathology 26:72–81

    Article  PubMed  Google Scholar 

  9. Huhn SL, Yung Y, Cheshier S, et al (2005) Identification of phenotypic neural stem cells in a pediatric astroblastoma. J Neurosurg 103:446–450

    PubMed  Google Scholar 

  10. Kim DS, Park SY, Lee SP (2004) Astroblastoma: a case report. J Korean Med Sci 19:772–776

    Article  PubMed  Google Scholar 

  11. Husain AN, Leestma JE (1986) Cerebral astroblastoma: immunohistochemical and ultrastructural features. Case report. J Neurosurg 64:657–661

    PubMed  CAS  Google Scholar 

  12. Cabello A, Madero S, Castresana A, et al (1991) Astroblastoma: electron microscopy and immunohistochemical findings: case report. Surg Neurol 35:116–121

    Article  PubMed  CAS  Google Scholar 

  13. Caroli E, Salvati M, Esposito V, et al (2004) Cerebral astroblastoma. Acta Neurochir 146:629–633

    Article  CAS  Google Scholar 

  14. Sugita Y, Terasaki M, Shigemori M, et al (2002) Astroblastoma with unusual signet-ring-like cell components: a case report and literature review. Neuropathology 22:200–205

    Article  PubMed  Google Scholar 

  15. Yamashita J, Handa H, Yamagami T, et al (1985) Astroblastoma of pure type. Surg Neurol 24:218–222

    Article  PubMed  CAS  Google Scholar 

  16. Hoag G, Sima AA, Rozdilsky B (1986) Astroblastoma revisited: a report of three cases. Acta Neuropathol 70:10–16

    Article  PubMed  CAS  Google Scholar 

  17. Bonnin JM, Rubinstein LJ (1989) Astroblastomas: a pathological study of 23 tumors, with a postoperative follow-up in 13 patients. Neurosurgery 25:6–13

    Article  PubMed  CAS  Google Scholar 

  18. Hata N, Shono T, Yoshimoto K, et al (2006) An astroblastoma case associated with loss of heterozygosity on chromosome 9p. J Neuro-Oncol 80:69–73

    Article  Google Scholar 

  19. Miranda P, Lobato RD, Cabello A, et al (2006) Complete surgical resection of high-grade astroblastoma with long time survival: case report and review of the literature. Neurocirugia (Asturias, Spain) 17:60–63

    CAS  Google Scholar 

  20. Thiessen B, Finlay J, Kulkarni R, et al (1998) Astroblastoma: does histology predict biologic behavior? J Neuro-Oncol 40:59–65

    Article  CAS  Google Scholar 

  21. Kubota T, Hirano A, Sato K, et al (1985) The fine structure of astroblastoma. Cancer (Phila) 55:745–750

    Article  CAS  Google Scholar 

  22. Takebayashi H, Nabeshima Y, Yoshida S, et al (2002) The basic helix-loo-helix factor olig2 is essential for the development of motoneuron and oligodendrocyte lineages. Curr Biol 12:1157–1163

    Article  PubMed  CAS  Google Scholar 

  23. Setoguchi T, Kondo T (2004) Nuclear export of OLIG2 in neural stem cells is essential for ciliary neurotrophic factor-induced astrocyte differentiation. J Cell Biol 166:963–968

    Article  PubMed  CAS  Google Scholar 

  24. Pizer BL, Moss T, Oakhill A, et al (1995) Congenital astroblastoma: an immunohistochemical study. Case report. J Neurosurg 83:550–555

    Article  PubMed  CAS  Google Scholar 

  25. Shuangshoti S, Mitphraphan W, Kanvisetsri S, et al (2000) Astroblastoma: report of a case with microsatellite analysis. Neuropathology 20:228–232

    Article  PubMed  CAS  Google Scholar 

  26. Takebayashi H, Yoshida S, Sugimori M, et al (2000) Dynamic expression of basic helix-loop-helix Olig family members: implication of Olig2 in neuron and oligodendrocyte differentiation and identification of a new member, Olig3. Mech Dev 99: 143–148

    Article  PubMed  CAS  Google Scholar 

  27. Brat DJ, Hirose Y, Cohen KJ, et al (2000) Astroblastoma: clinicopathologic features and chromosomal abnormalities defined by comparative genomic hybridization. Brain Pathol (Zurich) 10:342–352

    CAS  Google Scholar 

  28. Kraus JA, Koopmann J, Kaskel P, et al (1995) Shared allelic losses on chromosomes 1p and 19q suggest a common origin of oligodendroglioma and oligoastrocytoma. J Neuropathol Exp Neurol 54: 91–95

    PubMed  CAS  Google Scholar 

  29. Rubinstein LJ, Herman MM (1989) The astroblastoma and its possible cytogenic relationship to the tanycyte. An electron microscopic, immunohistochemical, tissue-and organ-culture study. Acta Neuropathol 78:472–483

    Article  PubMed  CAS  Google Scholar 

  30. Navarro R, Reitman AJ, de Leon GA, et al (2005) Astroblastoma in childhood: pathological and clinical analysis. Childs Nerv Syst 21:211–220

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Neurosurgery, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima, 890-8520, Japan

    Hirofumi Hirano, Shunji Yunoue, Masatomo Kaji, Masahiro Tsuchiya & Kazunori Arita

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  1. Hirofumi Hirano
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  2. Shunji Yunoue
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  3. Masatomo Kaji
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  4. Masahiro Tsuchiya
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  5. Kazunori Arita
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Correspondence to Hirofumi Hirano.

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Hirano, H., Yunoue, S., Kaji, M. et al. Consecutive histological changes in an astroblastoma that disseminated to the spinal cord after repeated intracranial recurrences: a case report. Brain Tumor Pathol 25, 25–31 (2008). https://doi.org/10.1007/s10014-007-0224-2

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  • DOI: https://doi.org/10.1007/s10014-007-0224-2

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