Abstract
Introduction
Astroblastoma is a rare glial tumor of uncertain origin. Only a few scattered case reports and one small case series have described the radiologic appearance of this uncommon tumor. Many features previously identified are similar to those of other primary malignant brain tumors. We report the largest imaging series to date and further delineate the CT and MRI features of astroblastoma. We identify those features that may be useful in distinguishing astroblastoma from other neoplasms.
Methods
The radiologic images, pathology reports, and clinical information of 12 patients with pathology-confirmed astroblastoma were retrospectively reviewed. CT and MRI findings including location, morphology, signal intensity, and presence and patterns of enhancement were tabulated.
Results
Patients ranged in age from 0 (newborn) to 50 years with a mean of 20 years at the time of initial diagnosis. A striking female preponderance (11:1) was found. All tumors were supratentorial. There were multiple intratumoral cysts in 7 (58%) of the 12 patients. Nine (75%) showed strong rim enhancement and 3 (25%) showed no rim enhancement.
Conclusion
The imaging features of astroblastoma are identified in 12 previously unreported cases. Distinguishing features that can be used to narrow the differential diagnosis with more common primary brain neoplasms reflect a combination of age, anatomic location, and specific imaging findings such as demarcation, heterogeneous tumor enhancement, rim enhancement, and a multicystic “bubbly” appearance. Intraventricular location, intratumoral hemorrhage with a fluid-fluid level, and dural “tails” are less common but important additions to the imaging spectrum.
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References
Scharenberg K, Liss L (1969) Neuroectodermal tumors of the central and peripheral nervous system. Williams & Wilkins, Baltimore, pp 17–29
Bergstrand H (1932) Über das sog. Astrocytom in Keinhirn. Virchows Arch A Pathol Anat Histopathol 287:538–548
Bailey P, Bucy PC (1930) Astroblastomas of the brain. Acta Psychiat Neurol Scand 5:439–461
Baka J, Patel S, Roebuck J (1993) Predominantly extraaxial astroblastoma: imaging and proton MR spectroscopy features. AJNR Am J Neuroradiol 14:946–950
Sener R (2002) Astroblastoma: diffusion MRI and proton MR spectroscopy. Comput Med Imaging Graph 26:187–191
Cabrera-Zubizarreta A, Caton B, Martinez de Guerenu B, Larena-Iturbe JA, Ontanon JM, Catalan-Urribarrena G (2002) Low grade astroblastoma: pathological and magnetic resonance findings. Rev Neurol 34:936–939
Port J, Brat D, Burger C, Pomper M (2002) Astroblastoma: radiologic-pathologic correlation and distinction from ependymoma. AJNR Am J Neuroradiol 23:243–247
Kleihues P, Cavenee WK (2000) World Health Organization classification of tumor pathology and genetics of tumors of the central nervous system. IARC Press, Lyon
Bonnin J, Rubinstein L (1989) Astroblastomas: a pathological study of 23 tumors, with a postoperative follow-up in 13 patients. Neurosurgery 25:6–13
Navarro R, Reitman A, Guillarmo A (2005) Astroblastoma in childhood: pathological and clinical analysis. Childs Nerv Syst 21:211–220
Thiessen B, Finlay J, Kulkarni R, Rosenblum MK (1998) Astroblastoma: does histology predict biologic behavior? J Neurooncol 40:59–65
Osborn A, Blaser S, Salzman K, et al (2004) Diagnostic imaging, brain. Amirsys, Salt Lake City, pp 16–100
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Bell, J.W., Osborn, A.G., Salzman, K.L. et al. Neuroradiologic characteristics of astroblastoma. Neuroradiology 49, 203–209 (2007). https://doi.org/10.1007/s00234-006-0182-0
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DOI: https://doi.org/10.1007/s00234-006-0182-0