Abstract
Methotrexate (MTX) is an antineoplastic drug widely used in cancer therapies with potentially toxic activity. This paper describes the electrochemical behavior of MTX in ITO (indium tin oxide) electrodes modified with nanostructured films containing biopolymers extracted from babassu mesocarp (BM) (Orbignya phalerata), aiming to develop electrochemical sensors for this drug. After combining PVS (polyvinyl sodium sulfonate) with BM, the analytical sensitivity of the sensor was improved from 2.49 (ITO) to 5.55 μA μmol L−1 (ITO/PVS/BM). The modification of the ITO with the proposed film yielded a detection limit of 5.95 × 10−7 mol L−1 for MTX. The presence of BM in the film considerably increased the sensor roughness as well as the interactions with MTX, which improved the analytical performance of the proposed system. This study demonstrated the possibility of quantifying MTX with electrochemical techniques using natural polymers, which can yield great financial and health benefits.
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Acknowledgments
The authors would like to thank the Federal University of Piauí (UFPI) and Federal Institute of Piauí (IFPI) for providing the research and work facilities.
Funding
The authors would like to thank the Coordination for the Improvement of Higher Education Personnel (CAPES), National Council for Scientific and Technological Development (CNPq, grant number 001), and Foundation for Research Support of Piauí (FAPEPI) for their financial support.
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Lima, H.R.S., Airton de Oliveira Farias, E., Teixeira, P.R.S. et al. Blend films based on biopolymers extracted from babassu mesocarp (Orbignya phalerata) for the electrochemical detection of methotrexate antineoplastic drug. J Solid State Electrochem 23, 3153–3164 (2019). https://doi.org/10.1007/s10008-019-04406-2
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DOI: https://doi.org/10.1007/s10008-019-04406-2