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Posttranslational phosphorylation of mutant p53 protein in tumor development

  • SPECIAL REVIEW SERIES: Molecular morphological approach for pathogenesis of hepatogastrointestinal diseases
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Abstract

p53 has been called the “cellular gatekeeper” and the “genome guard,” because in response to exposure to DNA-damaging agents, it induces cell-cycle arrest in G1 or apoptosis and also directly affects DNA replication. Multiple mechanisms regulate p53 activity and posttranslational modification, including multisite phosphorylation of wild-type p53, in particular. Normal functions of wild-type p53 are abrogated by mutation of this gene, and oncogenic studies have revealed that p53 mutation is among the most common genetic alteration in human cancers. It is generally accepted that mutant p53 protein may not only lose the tumor suppressor functions of wild-type p53 but also acquire additional tumorigenetic roles, including dominant-negative effects and gain of function. Although many studies have revealed such aberrant functions of mutant p53, less is known about the posttranslational phosphorylation status of mutant p53 and novel biological functions of phosphorylation in carcinogenesis.

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References

  1. AJ Levine J Momand CA Finlay (1991) ArticleTitleThe p53 tumour suppressor gene Nature (Lond) 351 453–456 Occurrence Handle10.1038/351453a0 Occurrence Handle1:CAS:528:DyaK3MXksVaku7g%3D

    Article  CAS  Google Scholar 

  2. SW Lowe EM Schmitt SW Smith BA Osborne T Jacks (1993) ArticleTitlep53 is required for radiation-induced apoptosis in mouse thymocytes Nature (Lond) 362 847–849 Occurrence Handle10.1038/362847a0 Occurrence Handle1:CAS:528:DyaK3sXktVCjurw%3D

    Article  CAS  Google Scholar 

  3. LS Cox T Hupp CA Midgley DP Lane (1995) ArticleTitleA direct effect of activated human p53 on nuclear DNA replication EMBO J 14 2099–2105 Occurrence Handle7744015 Occurrence Handle1:CAS:528:DyaK2MXlvVCqs7s%3D

    PubMed  CAS  Google Scholar 

  4. WS el-Deiry (1998) ArticleTitleRegulation of p53 downstream genes Semin Cancer Biol 8 345–357 Occurrence Handle10101800 Occurrence Handle10.1006/scbi.1998.0097 Occurrence Handle1:CAS:528:DyaK1MXitlSks7Y%3D

    Article  PubMed  CAS  Google Scholar 

  5. KH Vousden (2000) ArticleTitlep53: death star Cell 103 691–694 Occurrence Handle11114324 Occurrence Handle10.1016/S0092-8674(00)00171-9 Occurrence Handle1:CAS:528:DC%2BD3cXos1Snuro%3D

    Article  PubMed  CAS  Google Scholar 

  6. AM Bode Z Dong (2004) ArticleTitlePost-translational modification of p53 in tumorigenesis Nat Rev Cancer 4 793–805 Occurrence Handle15510160 Occurrence Handle10.1038/nrc1455 Occurrence Handle1:CAS:528:DC%2BD2cXos1ymu7o%3D

    Article  PubMed  CAS  Google Scholar 

  7. DW Meek (1994) ArticleTitlePost-transcriptional modification of p53 Semin Cancer Biol 5 203–210 Occurrence Handle7948948 Occurrence Handle1:CAS:528:DyaK2cXlvFylsL0%3D

    PubMed  CAS  Google Scholar 

  8. C Prives (1998) ArticleTitleSignaling to p53: breaking the MDM2-p53 circuit Cell 95 5–8 Occurrence Handle9778240 Occurrence Handle10.1016/S0092-8674(00)81774-2 Occurrence Handle1:CAS:528:DyaK1cXmslWmu7k%3D

    Article  PubMed  CAS  Google Scholar 

  9. AJ Giaccia MB Kastan (1998) ArticleTitleThe complexity of p53 modulation: emerging patterns from divergent signals Genes Dev 12 2973–2983 Occurrence Handle9765199 Occurrence Handle1:CAS:528:DyaK1cXmslejtbs%3D

    PubMed  CAS  Google Scholar 

  10. K Sakaguchi H Sakamoto MS Lewis CW Anderson JW Erickson E Appella D Xie (1997) ArticleTitlePhosphorylation of serine 392 stabilizes the tetramer formation of tumor suppressor protein p53 Biochemistry 36 10117–10124 Occurrence Handle9254608 Occurrence Handle10.1021/bi970759w Occurrence Handle1:CAS:528:DyaK2sXkvVWntLg%3D

    Article  PubMed  CAS  Google Scholar 

  11. M Ashcroft MH Kubbutat KH Vousden (1999) ArticleTitleRegulation of p53 function and stability by phosphorylation Mol Cell Biol 19 1751–1758 Occurrence Handle10022862 Occurrence Handle1:CAS:528:DyaK1MXhsFeqt7w%3D

    PubMed  CAS  Google Scholar 

  12. SY Shieh M Ikeda Y Taya C Prives (1997) ArticleTitleDNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2 Cell 91 325–334 Occurrence Handle9363941 Occurrence Handle10.1016/S0092-8674(00)80416-X Occurrence Handle1:CAS:528:DyaK2sXnt1CltLY%3D

    Article  PubMed  CAS  Google Scholar 

  13. WS El-Deiry SE Kern JA Pietenpol KW Kinzler B Vogelstein (1992) ArticleTitleDefinition of a consensus binding site for p53 Nat Genet 1 45–49 Occurrence Handle1301998 Occurrence Handle10.1038/ng0492-45 Occurrence Handle1:CAS:528:DyaK38Xkt1Wntrk%3D

    Article  PubMed  CAS  Google Scholar 

  14. Y Cho S Gorina PD Jeffrey NP Pavletich (1994) ArticleTitleCrystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations Science 265 346–355 Occurrence Handle8023157 Occurrence Handle1:CAS:528:DyaK2cXlslegs7k%3D

    PubMed  CAS  Google Scholar 

  15. SE Kern KW Kinzler A Bruskin D Jarosz P Friedman C Prives B Vogelstein (1991) ArticleTitleIdentification of p53 as a sequence-specific DNA-binding protein Science 252 1708–1711 Occurrence Handle2047879 Occurrence Handle1:CAS:528:DyaK3MXkvVKmurs%3D

    PubMed  CAS  Google Scholar 

  16. C Cadwell GP Zambetti (2001) ArticleTitleThe effects of wild-type p53 tumor suppressor activity and mutant p53 gain-of-function on cell growth Gene (Amst) 277 15–30 Occurrence Handle10.1016/S0378-1119(01)00696-5 Occurrence Handle1:CAS:528:DC%2BD3MXnsFGgtLk%3D

    Article  CAS  Google Scholar 

  17. MG van Oijen PJ Slootweg (2000) ArticleTitleGain-of-function mutations in the tumor suppressor gene p53 Clin Cancer Res 6 2138–2145 Occurrence Handle10873062 Occurrence Handle1:CAS:528:DC%2BD3cXksVGiu7c%3D

    PubMed  CAS  Google Scholar 

  18. SJ Ullrich K Sakaguchi SP Lees-Miller M Fiscella WE Mercer CW Anderson E Appella (1993) ArticleTitlePhosphorylation at Ser-15 and Ser-392 in mutant p53 molecules from human tumors is altered compared to wild-type p53 Proc Natl Acad Sci U S A 90 5954–5958 Occurrence Handle8327466 Occurrence Handle10.1073/pnas.90.13.5954 Occurrence Handle1:CAS:528:DyaK3sXltlKmtbw%3D

    Article  PubMed  CAS  Google Scholar 

  19. Y Nagata T Anan T Yoshida T Mizukami Y Taya T Fujiwara H Kato H Saya M Nakao (1999) ArticleTitleThe stabilization mechanism of mutant-type p53 by impaired ubiquitination: the loss of wild-type p53 function and the hsp90 association Oncogene 18 6037–6049 Occurrence Handle10557093 Occurrence Handle10.1038/sj.onc.1202978 Occurrence Handle1:CAS:528:DyaK1MXntlGitbo%3D

    Article  PubMed  CAS  Google Scholar 

  20. T Minamoto T Buschmann H Habelhah E Matusevich H Tahara AL Boerresen-Dale C Harris D Sidransky Z Ronai (2001) ArticleTitleDistinct pattern of p53 phosphorylation in human tumors Oncogene 20 3341–3347 Occurrence Handle11423984 Occurrence Handle10.1038/sj.onc.1204458 Occurrence Handle1:CAS:528:DC%2BD3MXltVSqsbk%3D

    Article  PubMed  CAS  Google Scholar 

  21. VO Melnikova AB Santamaria SV Bolshakov HN Ananthaswamy (2003) ArticleTitleMutant p53 is constitutively phosphorylated at Serine 15 in UV-induced mouse skin tumors: involvement of ERK1/2 MAP kinase Oncogene 22 5958–5966 Occurrence Handle12955074 Occurrence Handle10.1038/sj.onc.1206595 Occurrence Handle1:CAS:528:DC%2BD3sXmvFans7c%3D

    Article  PubMed  CAS  Google Scholar 

  22. DB Yap JK Hsieh S Zhong V Heath B Gusterson T Crook X Lu (2004) ArticleTitleSer392 phosphorylation regulates the oncogenic function of mutant p53 Cancer Res 64 4749–4754 Occurrence Handle15256442 Occurrence Handle10.1158/0008-5472.CAN-1305-2 Occurrence Handle1:CAS:528:DC%2BD2cXls1OmsLs%3D

    Article  PubMed  CAS  Google Scholar 

  23. M Isobe BS Emanuel D Givol M Oren CM Croce (1986) ArticleTitleLocalization of gene for human p53 tumour antigen to band 17p13 Nature (Lond) 320 84–85 Occurrence Handle10.1038/320084a0 Occurrence Handle1:CAS:528:DyaL28Xhs1Kms7o%3D

    Article  CAS  Google Scholar 

  24. OW McBride D Merry D Givol (1986) ArticleTitleThe gene for human p53 cellular tumor antigen is located on chromosome 17 short arm (17p13) Proc Natl Acad Sci U S A 83 130–134 Occurrence Handle3001719 Occurrence Handle10.1073/pnas.83.1.130 Occurrence Handle1:CAS:528:DyaL28Xot12qsw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  25. C Miller T Mohandas D Wolf M Prokocimer V Rotter HP Koeffler (1986) ArticleTitleHuman p53 gene localized to short arm of chromosome 17 Nature (Lond) 319 783–784 Occurrence Handle10.1038/319783a0 Occurrence Handle1:CAS:528:DyaL28XhsVeisrs%3D

    Article  CAS  Google Scholar 

  26. T Soussi C Caron de Fromentel P May (1990) ArticleTitleStructural aspects of the p53 protein in relation to gene evolution Oncogene 5 945–952 Occurrence Handle2142762 Occurrence Handle1:CAS:528:DyaK3cXkvFegtL8%3D

    PubMed  CAS  Google Scholar 

  27. S Fields SK Jang (1990) ArticleTitlePresence of a potent transcription activating sequence in the p53 protein Science 249 1046–1049 Occurrence Handle2144363 Occurrence Handle1:CAS:528:DyaK3cXls1Klt70%3D

    PubMed  CAS  Google Scholar 

  28. L Raycroft HY Wu G Lozano (1990) ArticleTitleTranscriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene Science 249 1049–1051 Occurrence Handle2144364 Occurrence Handle1:CAS:528:DyaK3cXls1Klt7o%3D

    PubMed  CAS  Google Scholar 

  29. J Chen V Marechal AJ Levine (1993) ArticleTitleMapping of the p53 and mdm-2 interaction domains Mol Cell Biol 13 4107–4114 Occurrence Handle7686617 Occurrence Handle1:CAS:528:DyaK3sXlsFehu74%3D

    PubMed  CAS  Google Scholar 

  30. JD Oliner JA Pietenpol S Thiagalingam J Gyuris KW Kinzler B Vogelstein (1993) ArticleTitleOncoprotein MDM2 conceals the activation domain of tumour suppressor p53 Nature (Lond) 362 857–860 Occurrence Handle10.1038/362857a0 Occurrence Handle1:CAS:528:DyaK3sXkt1ait7g%3D

    Article  CAS  Google Scholar 

  31. E Seto A Usheva GP Zambetti J Momand N Horikoshi R Weinmann AJ Levine T Shenk (1992) ArticleTitleWild-type p53 binds to the TATA-binding protein and represses transcription Proc Natl Acad Sci U S A 89 12028–12032 Occurrence Handle1465435 Occurrence Handle10.1073/pnas.89.24.12028 Occurrence Handle1:CAS:528:DyaK3sXpsFGjtQ%3D%3D

    Article  PubMed  CAS  Google Scholar 

  32. X Liu CW Miller PH Koeffler AJ Berk (1993) ArticleTitleThe p53 activation domain binds the TATA box-binding polypeptide in Holo-TFIID, and a neighboring p53 domain inhibits transcription Mol Cell Biol 13 3291–3300 Occurrence Handle8497252 Occurrence Handle1:CAS:528:DyaK3sXkvVyhsbg%3D

    PubMed  CAS  Google Scholar 

  33. R Truant H Xiao CJ Ingles J Greenblatt (1993) ArticleTitleDirect interaction between the transcriptional activation domain of human p53 and the TATA box-binding protein J Biol Chem 268 2284–2287 Occurrence Handle8428901 Occurrence Handle1:CAS:528:DyaK3sXhs1agtbg%3D

    PubMed  CAS  Google Scholar 

  34. LJ Ko C Prives (1996) ArticleTitlep53: puzzle and paradigm Genes Dev 10 1054–1072 Occurrence Handle8654922 Occurrence Handle1:CAS:528:DyaK28XjtFajtbs%3D

    PubMed  CAS  Google Scholar 

  35. AJ Levine (1997) ArticleTitlep53, the cellular gatekeeper for growth and division Cell 88 323–331 Occurrence Handle9039259 Occurrence Handle10.1016/S0092-8674(00)81871-1 Occurrence Handle1:CAS:528:DyaK2sXhtFahtLg%3D

    Article  PubMed  CAS  Google Scholar 

  36. ML Avantaggiati V Ogryzko K Gardner A Giordano AS Levine K Kelly (1997) ArticleTitleRecruitment of p300/CBP in p53-dependent signal pathways Cell 89 1175–1184 Occurrence Handle9215639 Occurrence Handle10.1016/S0092-8674(00)80304-9 Occurrence Handle1:CAS:528:DyaK2sXkt1Kksbk%3D

    Article  PubMed  CAS  Google Scholar 

  37. DM Scolnick NH Chehab ES Stavridi MC Lien L Caruso E Moran SL Berger TD Halazonetis (1997) ArticleTitleCREB-binding protein and p300/CBP-associated factor are transcriptional coactivators of the p53 tumor suppressor protein Cancer Res 57 3693–3696 Occurrence Handle9288775 Occurrence Handle1:CAS:528:DyaK2sXlvFentrc%3D

    PubMed  CAS  Google Scholar 

  38. A Dutta JM Ruppert JC Aster E Winchester (1993) ArticleTitleInhibition of DNA replication factor RPA by p53 Nature (Lond) 365 79–82 Occurrence Handle10.1038/365079a0 Occurrence Handle1:CAS:528:DyaK3sXmtVSrs78%3D

    Article  CAS  Google Scholar 

  39. Z He BT Brinton J Greenblatt JA Hassell CJ Ingles (1993) ArticleTitleThe transactivator proteins VP16 and GAL4 bind replication factor A Cell 73 1223–1232 Occurrence Handle8513504 Occurrence Handle10.1016/0092-8674(93)90650-F Occurrence Handle1:CAS:528:DyaK3sXksVenu7s%3D

    Article  PubMed  CAS  Google Scholar 

  40. A Jawhari S Boussert V Lamour RA Atkinson B Kieffer O Poch N Potier A van Dorsselaer D Moras A Poterszman (2004) ArticleTitleDomain architecture of the p62 subunit from the human transcription/repair factor TFIIH deduced by limited proteolysis and mass spectrometry analysis Biochemistry 43 14420–14430 Occurrence Handle15533047 Occurrence Handle10.1021/bi048884c Occurrence Handle1:CAS:528:DC%2BD2cXos1KhsL8%3D

    Article  PubMed  CAS  Google Scholar 

  41. D Sakamuro P Sabbatini E White GC Prendergast (1997) ArticleTitleThe polyproline region of p53 is required to activate apoptosis but not growth arrest Oncogene 15 887–898 Occurrence Handle9285684 Occurrence Handle10.1038/sj.onc.1201263 Occurrence Handle1:CAS:528:DyaK2sXlvFSisb0%3D

    Article  PubMed  CAS  Google Scholar 

  42. KK Walker AJ Levine (1996) ArticleTitleIdentification of a novel p53 functional domain that is necessary for efficient growth suppression Proc Natl Acad Sci U S A 93 15335–15340 Occurrence Handle8986812 Occurrence Handle10.1073/pnas.93.26.15335 Occurrence Handle1:CAS:528:DyaK2sXnt1Gk

    Article  PubMed  CAS  Google Scholar 

  43. X Li P Coffino (1996) ArticleTitleHigh-risk human papillomavirus E6 protein has two distinct binding sites within p53, of which only one determines degradation J Virol 70 4509–4516 Occurrence Handle8676476 Occurrence Handle1:CAS:528:DyaK28XjsFygs7Y%3D

    PubMed  CAS  Google Scholar 

  44. M Hollstein D Sidransky B Vogelstein CC Harris (1991) ArticleTitlep53 mutations in human cancers Science 253 49–53 Occurrence Handle1905840 Occurrence Handle1:CAS:528:DyaK3MXks1Gmurg%3D

    PubMed  CAS  Google Scholar 

  45. C Caron de Fromentel C Soussi (1992) ArticleTitleTP53 tumor suppressor gene: a model for investigating human mutagenesis Genes Chromosomes Cancer 4 1–15 Occurrence Handle1377002 Occurrence Handle1:STN:280:By2A3cvot1U%3D

    PubMed  CAS  Google Scholar 

  46. JR Jenkins P Chumakov C Addison HW Sturzbecher A Wade-Evans (1988) ArticleTitleTwo distinct regions of the murine p53 primary amino acid sequence are implicated in stable complex formation with simian virus 40 T antigen J Virol 62 3903–3906 Occurrence Handle3047431 Occurrence Handle1:CAS:528:DyaL1cXmt1Kls7w%3D

    PubMed  CAS  Google Scholar 

  47. JM Ruppert B Stillman (1993) ArticleTitleAnalysis of a protein-binding domain of p53 Mol Cell Biol 13 3811–3820 Occurrence Handle8388547 Occurrence Handle1:CAS:528:DyaK3sXkvVyhtro%3D

    PubMed  CAS  Google Scholar 

  48. S Gorina NP Pavletich (1996) ArticleTitleStructure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2 Science 274 1001–1005 Occurrence Handle8875926 Occurrence Handle10.1126/science.274.5289.1001 Occurrence Handle1:CAS:528:DyaK28XmslKmt7s%3D

    Article  PubMed  CAS  Google Scholar 

  49. K Iwabuchi PL Bartel B Li R Marraccino S Fields (1994) ArticleTitleTwo cellular proteins that bind to wild-type but not mutant p53 Proc Natl Acad Sci U S A 91 6098–6102 Occurrence Handle8016121 Occurrence Handle10.1073/pnas.91.13.6098 Occurrence Handle1:CAS:528:DyaK2cXlt1Krs7o%3D

    Article  PubMed  CAS  Google Scholar 

  50. Y Xu (2003) ArticleTitleRegulation of p53 responses by post-translational modifications Cell Death Differ 10 400–403 Occurrence Handle12719715 Occurrence Handle10.1038/sj.cdd.4401182 Occurrence Handle1:CAS:528:DC%2BD3sXjt1GjsLs%3D

    Article  PubMed  CAS  Google Scholar 

  51. S Kraiss A Quaiser M Oren M Montenarh (1988) ArticleTitleOligomerization of oncoprotein p53 J Virol 62 4737–4744 Occurrence Handle3054153 Occurrence Handle1:CAS:528:DyaL1MXlsFWnuw%3D%3D

    PubMed  CAS  Google Scholar 

  52. XW Wang W Vermeulen JD Coursen M Gibson SE Lupold K Forrester G Xu L Elmore H Yeh JH Hoeijmakers CC Harris (1996) ArticleTitleThe XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway Genes Dev 10 1219–1232 Occurrence Handle8675009 Occurrence Handle1:CAS:528:DyaK28XjtlCnu74%3D

    PubMed  CAS  Google Scholar 

  53. Y Wang C Prives (1995) ArticleTitleIncreased and altered DNA binding of human p53 by S and G2/M but not G1 cyclin-dependent kinases Nature (Lond) 376 88–91 Occurrence Handle10.1038/376088a0 Occurrence Handle1:CAS:528:DyaK2MXmvVKjs74%3D

    Article  CAS  Google Scholar 

  54. P May E May (1999) ArticleTitleTwenty years of p53 research: structural and functional aspects of the p53 protein Oncogene 18 7621–7636 Occurrence Handle10618702 Occurrence Handle10.1038/sj.onc.1203285 Occurrence Handle1:CAS:528:DC%2BD3cXmt1Skuw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  55. TR Hupp A Sparks DP Lane (1995) ArticleTitleSmall peptides activate the latent sequence-specific DNA binding function of p53 Cell 83 237–245 Occurrence Handle7585941 Occurrence Handle10.1016/0092-8674(95)90165-5 Occurrence Handle1:CAS:528:DyaK2MXovVGrtbc%3D

    Article  PubMed  CAS  Google Scholar 

  56. S Kaku A Albor M Kulesz-Martin (2001) ArticleTitleDissociation of DNA binding and in vitro transcriptional activities dependent on the C terminus of P53 proteins Biochem Biophys Res Commun 280 204–211 Occurrence Handle11162500 Occurrence Handle10.1006/bbrc.2000.4060 Occurrence Handle1:CAS:528:DC%2BD3MXivVehtg%3D%3D

    Article  PubMed  CAS  Google Scholar 

  57. G Shaulsky N Goldfinger A Ben-Ze’ev V Rotter (1990) ArticleTitleNuclear accumulation of p53 protein is mediated by several nuclear localization signals and plays a role in tumorigenesis Mol Cell Biol 10 6565–6577 Occurrence Handle2247074 Occurrence Handle1:CAS:528:DyaK3MXpvFWqsQ%3D%3D

    PubMed  CAS  Google Scholar 

  58. J Momand GP Zambetti DC Olson D George AJ Levine (1992) ArticleTitleThe mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation Cell 69 1237–1245 Occurrence Handle1535557 Occurrence Handle10.1016/0092-8674(92)90644-R Occurrence Handle1:CAS:528:DyaK3sXit1Ogs7o%3D

    Article  PubMed  CAS  Google Scholar 

  59. X Wu JH Bayle D Olson AJ Levine (1993) ArticleTitleThe p53-mdm-2 autoregulatory feedback loop Genes Dev 7 1126–1132 Occurrence Handle8319905 Occurrence Handle1:CAS:528:DyaK3sXlslGhtLo%3D

    PubMed  CAS  Google Scholar 

  60. S Maheswaran S Park A Bernard JF Morris FJ Rauscher Suffix3rd DE Hill DA Haber (1993) ArticleTitlePhysical and functional interaction between WT1 and p53 proteins Proc Natl Acad Sci U S A 90 5100–5104 Occurrence Handle8389468 Occurrence Handle10.1073/pnas.90.11.5100 Occurrence Handle1:CAS:528:DyaK3sXks12hurY%3D

    Article  PubMed  CAS  Google Scholar 

  61. WS El-Deiry T Tokino VE Velculescu DB Levy R Parsons JM Trent D Lin WE Mercer KW Kinzler B Vogelstein (1993) ArticleTitleWAF1, a potential mediator of p53 tumor suppression Cell 75 817–825 Occurrence Handle8242752 Occurrence Handle10.1016/0092-8674(93)90500-P Occurrence Handle1:CAS:528:DyaK2cXpslGguw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  62. M Nakanishi Y Kaneko H Matsushime K Ikeda (1999) ArticleTitleDirect interaction of p21 cyclin-dependent kinase inhibitor with the retinoblastoma tumor suppressor protein Biochem Biophys Res Commun 263 35–40 Occurrence Handle10486249 Occurrence Handle10.1006/bbrc.1999.1296 Occurrence Handle1:CAS:528:DyaK1MXlvVWqtbs%3D

    Article  PubMed  CAS  Google Scholar 

  63. M Oren (2003) ArticleTitleDecision making by p53: life, death and cancer Cell Death Differ 10 431–442 Occurrence Handle12719720 Occurrence Handle10.1038/sj.cdd.4401183 Occurrence Handle1:CAS:528:DC%2BD3sXjt1GjsLg%3D

    Article  PubMed  CAS  Google Scholar 

  64. T Miyashita M Harigai M Hanada JC Reed (1994) ArticleTitleIdentification of a p53-dependent negative response element in the bcl-2 gene Cancer Res 54 3131–3135 Occurrence Handle8205530 Occurrence Handle1:CAS:528:DyaK2cXkslGit7o%3D

    PubMed  CAS  Google Scholar 

  65. M Murphy A Hinman AJ Levine (1996) ArticleTitleWild-type p53 negatively regulates the expression of a microtubule-associated protein Genes Dev 10 2971–2980 Occurrence Handle8956998 Occurrence Handle1:CAS:528:DyaK28XnsV2nt7Y%3D

    PubMed  CAS  Google Scholar 

  66. X Wu AJ Levine (1994) ArticleTitlep53 and E2F-1 cooperate to mediate apoptosis Proc Natl Acad Sci U S A 91 3602–3606 Occurrence Handle8170954 Occurrence Handle10.1073/pnas.91.9.3602 Occurrence Handle1:CAS:528:DyaK2cXivFGitbg%3D

    Article  PubMed  CAS  Google Scholar 

  67. TR Hupp DW Meek CA Midgley DP Lane (1992) ArticleTitleRegulation of the specific DNA binding function of p53 Cell 71 875–886 Occurrence Handle1423635 Occurrence Handle10.1016/0092-8674(92)90562-Q Occurrence Handle1:CAS:528:DyaK3sXlslaktg%3D%3D

    Article  PubMed  CAS  Google Scholar 

  68. SR Hall LE Campbell DW Meek (1996) ArticleTitlePhosphorylation of p53 at the casein kinase II site selectively regulates p53-dependent transcriptional repression but not transactivation Nucleic Acids Res 24 1119–1126 Occurrence Handle8604347 Occurrence Handle10.1093/nar/24.6.1119 Occurrence Handle1:CAS:528:DyaK28XitFGktb0%3D

    Article  PubMed  CAS  Google Scholar 

  69. GA Mayr M Reed P Wang Y Wang JF Schweds P Tegtmeyer (1995) ArticleTitleSerine phosphorylation in the NH2 terminus of p53 facilitates transactivation Cancer Res 55 2410–2417 Occurrence Handle7757994 Occurrence Handle1:CAS:528:DyaK2MXlvFeqs7g%3D

    PubMed  CAS  Google Scholar 

  70. EL Paley (1996) ArticleTitlePhosphorylation of T antigen and p53 in carcinogen-treated SV40-transformed Chinese hamster cells Carcinogenesis (Oxf) 17 939–945 Occurrence Handle1:CAS:528:DyaK28Xjt1Kltrk%3D

    CAS  Google Scholar 

  71. M Fiscella N Zambrano SJ Ullrich T Unger D Lin B Cho WE Mercer CW Anderson E Appella (1994) ArticleTitleThe carboxy-terminal serine 392 phosphorylation site of human p53 is not required for wild-type activities Oncogene 9 3249–3257 Occurrence Handle7936649 Occurrence Handle1:CAS:528:DyaK2cXmvFCgtbw%3D

    PubMed  CAS  Google Scholar 

  72. T Crook NJ Marston EA Sara KH Vousden (1994) ArticleTitleTranscriptional activation by p53 correlates with suppression of growth but not transformation Cell 79 817–827 Occurrence Handle8001119 Occurrence Handle10.1016/0092-8674(94)90071-X Occurrence Handle1:CAS:528:DyaK2MXisV2kt7c%3D

    Article  PubMed  CAS  Google Scholar 

  73. A Gatti HH Li JA Traugh X Liu (2000) ArticleTitlePhosphorylation of human p53 on Thr-55 Biochemistry 39 9837–9842 Occurrence Handle10933801 Occurrence Handle10.1021/bi992454i Occurrence Handle1:CAS:528:DC%2BD3cXkvFamsbc%3D

    Article  PubMed  CAS  Google Scholar 

  74. T Unger T Juven-Gershon E Moallem M Berger R Vogt Sionov G Lozano M Oren Y Haupt (1999) ArticleTitleCritical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2 EMBO J 18 1805–1814 Occurrence Handle10202144 Occurrence Handle10.1093/emboj/18.7.1805 Occurrence Handle1:CAS:528:DyaK1MXivVyksrw%3D

    Article  PubMed  CAS  Google Scholar 

  75. L Qu S Huang D Baltzis AM Rivas-Estilla O Pluquet M Hatzoglou C Koumenis Y Taya A Yoshimura AE Koromilas (2004) ArticleTitleEndoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta Genes Dev 18 261–277 Occurrence Handle14744935 Occurrence Handle10.1101/gad.1165804 Occurrence Handle1:CAS:528:DC%2BD2cXhsFaltrc%3D

    Article  PubMed  CAS  Google Scholar 

  76. MJ Waterman ES Stavridi JL Waterman TD Halazonetis (1998) ArticleTitleATM-dependent activation of p53 involves dephosphorylation and association with 14–3-3 proteins Nat Genet 19 175–178 Occurrence Handle9620776 Occurrence Handle10.1038/542 Occurrence Handle1:CAS:528:DyaK1cXls1Cru7Y%3D

    Article  PubMed  CAS  Google Scholar 

  77. DM Keller X Zeng Y Wang QH Zhang M Kapoor H Shu R Goodman G Lozano Y Zhao H Lu (2001) ArticleTitleA DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1 Mol Cell 7 283–292 Occurrence Handle11239457 Occurrence Handle10.1016/S1097-2765(01)00176-9 Occurrence Handle1:CAS:528:DC%2BD3MXis1Kit74%3D

    Article  PubMed  CAS  Google Scholar 

  78. H Lu RP Fisher P Bailey AJ Levine (1997) ArticleTitleThe CDK7-cycH-p36 complex of transcription factor IIH phosphorylates p53, enhancing its sequence-specific DNA binding activity in vitro Mol Cell Biol 17 5923–5934 Occurrence Handle9315650 Occurrence Handle1:CAS:528:DyaK2sXmtlOisr8%3D

    PubMed  CAS  Google Scholar 

  79. DM Milne L McKendrick LJ Jardine E Deacon JM Lord DW Meek (1996) ArticleTitleMurine p53 is phosphorylated within the PAb421 epitope by protein kinase C in vitro, but not in vivo, even after stimulation with the phorbol ester o-tetradecanoylphorbol 13-acetate Oncogene 13 205–211 Occurrence Handle8700548 Occurrence Handle1:CAS:528:DyaK28Xks1entr0%3D

    PubMed  CAS  Google Scholar 

  80. JR Bischoff PN Friedman DR Marshak C Prives D Beach (1990) ArticleTitleHuman p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2 Proc Natl Acad Sci U S A 87 4766–4770 Occurrence Handle2141171 Occurrence Handle10.1073/pnas.87.12.4766 Occurrence Handle1:CAS:528:DyaK3cXlt1ymsLc%3D

    Article  PubMed  CAS  Google Scholar 

  81. SP Lees-Miller K Sakaguchi SJ Ullrich E Appella CW Anderson (1992) ArticleTitleHuman DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53 Mol Cell Biol 12 5041–5049 Occurrence Handle1406679 Occurrence Handle1:CAS:528:DyaK3sXhsVagsLY%3D

    PubMed  CAS  Google Scholar 

  82. J Baudier C Delphin D Grunwald S Khochbin JJ Lawrence (1992) ArticleTitleCharacterization of the tumor suppressor protein p53 as a protein kinase C substrate and a S100b-binding protein Proc Natl Acad Sci U S A 89 11627–11631 Occurrence Handle1454855 Occurrence Handle10.1073/pnas.89.23.11627 Occurrence Handle1:CAS:528:DyaK3sXlslSqtA%3D%3D

    Article  PubMed  CAS  Google Scholar 

  83. RT Abraham (2001) ArticleTitleCell cycle checkpoint signaling through the ATM and ATR kinases Genes Dev 15 2177–2196 Occurrence Handle11544175 Occurrence Handle10.1101/gad.914401 Occurrence Handle1:CAS:528:DC%2BD3MXmvFSruro%3D

    Article  PubMed  CAS  Google Scholar 

  84. LJ Ko SY Shieh X Chen L Jayaraman K Tamai Y Taya C Prives ZQ Pan (1997) ArticleTitlep53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner Mol Cell Biol 17 7220–7229 Occurrence Handle9372954 Occurrence Handle1:CAS:528:DyaK2sXnsFWgsLs%3D

    PubMed  CAS  Google Scholar 

  85. DL Persons EM Yazlovitskaya JC Pelling (2000) ArticleTitleEffect of extracellular signal-regulated kinase on p53 accumulation in response to cisplatin J Biol Chem 275 35778–35785 Occurrence Handle10958792 Occurrence Handle10.1074/jbc.M004267200 Occurrence Handle1:CAS:528:DC%2BD3cXosVSktr0%3D

    Article  PubMed  CAS  Google Scholar 

  86. N Dumaz DM Milne DW Meek (1999) ArticleTitleProtein kinase CK1 is a p53-threonine 18 kinase which requires prior phosphorylation of serine 15 FEBS Lett 463 312–316 Occurrence Handle10606744 Occurrence Handle10.1016/S0014-5793(99)01647-6 Occurrence Handle1:CAS:528:DyaK1MXnvFemt70%3D

    Article  PubMed  CAS  Google Scholar 

  87. V Adler MR Pincus T Minamoto SY Fuchs MJ Bluth PW Brandt-Rauf FK Friedman RC Robinson JM Chen XW Wang CC Harris Z Ronai (1997) ArticleTitleConformation-dependent phosphorylation of p53 Proc Natl Acad Sci U S A 94 1686–1691 Occurrence Handle9050839 Occurrence Handle10.1073/pnas.94.5.1686 Occurrence Handle1:CAS:528:DyaK2sXhslalur0%3D

    Article  PubMed  CAS  Google Scholar 

  88. DW Meek LE Campbell LJ Jardine U Knippschild L McKendrick DM Milne (1997) ArticleTitleMulti-site phosphorylation of p53 by protein kinases inducible by p53 and DNA damage Biochem Soc Trans 25 416–419 Occurrence Handle9191128 Occurrence Handle1:CAS:528:DyaK2sXjs1ahsrs%3D

    PubMed  CAS  Google Scholar 

  89. CE Helt WA Cliby PC Keng RA Bambara MA O’Reilly (2005) ArticleTitleAtaxia telangiectasia mutated (ATM) and ATM and Rad3-related protein exhibit selective target specificities in response to different forms of DNA damage J Biol Chem 280 1186–1192 Occurrence Handle15533933 Occurrence Handle10.1074/jbc.M410873200 Occurrence Handle1:CAS:528:DC%2BD2MXitFCnsw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  90. R Araki R Fukumura A Fujimori Y Taya Y Shiloh A Kurimasa S Burma GC Li DJ Chen K Sato Y Hoki K Tatsumi M Abe (1999) ArticleTitleEnhanced phosphorylation of p53 serine 18 following DNA damage in DNA-dependent protein kinase catalytic subunit-deficient cells Cancer Res 59 3543–3546 Occurrence Handle10446957 Occurrence Handle1:CAS:528:DyaK1MXltFCgtb0%3D

    PubMed  CAS  Google Scholar 

  91. GS Jimenez F Bryntesson MI Torres-Arzayus A Priestley M Beeche S Saito K Sakaguchi E Appella PA Jeggo GE Taccioli GM Wahl M Hubank (1999) ArticleTitleDNA-dependent protein kinase is not required for the p53-dependent response to DNA damage Nature (Lond) 400 81–83 Occurrence Handle10.1038/21913 Occurrence Handle1:CAS:528:DyaK1MXksFehsrw%3D

    Article  CAS  Google Scholar 

  92. SY Shieh J Ahn K Tamai Y Taya C Prives (2000) ArticleTitleThe human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites Genes Dev 14 289–300 Occurrence Handle10673501 Occurrence Handle1:CAS:528:DC%2BD3cXhsVKhsro%3D

    PubMed  CAS  Google Scholar 

  93. NH Chehab A Malikzay M Appel TD Halazonetis (2000) ArticleTitleChk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53 Genes Dev 14 278–288 Occurrence Handle10673500 Occurrence Handle1:CAS:528:DC%2BD3cXhsVKhsr0%3D

    PubMed  CAS  Google Scholar 

  94. SY Shieh Y Taya C Prives (1999) ArticleTitleDNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization EMBO J 18 1815–1823 Occurrence Handle10202145 Occurrence Handle10.1093/emboj/18.7.1815 Occurrence Handle1:CAS:528:DyaK1MXivVyksr0%3D

    Article  PubMed  CAS  Google Scholar 

  95. T Unger T Juven-Gershon E Moallem M Berger R Vogt Sionov G Lozano M Oren Y Haupt (1999) ArticleTitleCritical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2 EMBO J 18 1805–1814 Occurrence Handle10202144 Occurrence Handle10.1093/emboj/18.7.1805 Occurrence Handle1:CAS:528:DyaK1MXivVyksrw%3D

    Article  PubMed  CAS  Google Scholar 

  96. NH Chehab A Malikzay ES Stavridi TD Halazonetis (1999) ArticleTitlePhosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage Proc Natl Acad Sci U S A 96 13777–13782 Occurrence Handle10570149 Occurrence Handle10.1073/pnas.96.24.13777 Occurrence Handle1:CAS:528:DyaK1MXns1Oqt74%3D

    Article  PubMed  CAS  Google Scholar 

  97. K Sakaguchi S Saito Y Higashimoto S Roy CW Anderson E Appella (2000) ArticleTitleDamage-mediated phosphorylation of human p53 threonine 18 through a cascade mediated by a casein 1-like kinase. Effect on Mdm2 binding J Biol Chem 275 9278–9283 Occurrence Handle10734067 Occurrence Handle10.1074/jbc.275.13.9278 Occurrence Handle1:CAS:528:DC%2BD3cXitlCrtLo%3D

    Article  PubMed  CAS  Google Scholar 

  98. E Appella CW Anderson (2001) ArticleTitlePost-translational modifications and activation of p53 by genotoxic stresses Eur J Biochem 268 2764–2772 Occurrence Handle11358490 Occurrence Handle10.1046/j.1432-1327.2001.02225.x Occurrence Handle1:CAS:528:DC%2BD3MXktVSktr8%3D

    Article  PubMed  CAS  Google Scholar 

  99. DV Bulavin S Saito MC Hollander K Sakaguchi CW Anderson E Appella AJ Fornace SuffixJr (1999) ArticleTitlePhosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation EMBO J 18 6845–6854 Occurrence Handle10581258 Occurrence Handle10.1093/emboj/18.23.6845 Occurrence Handle1:CAS:528:DC%2BD3cXhslyisA%3D%3D

    Article  PubMed  CAS  Google Scholar 

  100. C Huang WY Ma A Maxiner Y Sun Z Dong (1999) ArticleTitlep38 kinase mediates UV-induced phosphorylation of p53 protein at serine 389 J Biol Chem 274 12229–12235 Occurrence Handle10212189 Occurrence Handle10.1074/jbc.274.18.12229 Occurrence Handle1:CAS:528:DyaK1MXjtFGgtrY%3D

    Article  PubMed  CAS  Google Scholar 

  101. K Oda H Arakawa T Tanaka K Matsuda C Tanikawa T Mori H Nishimori K Tamai T Tokino Y Nakamura Y Taya (2000) ArticleTitlep53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53 Cell 102 849–862 Occurrence Handle11030628 Occurrence Handle10.1016/S0092-8674(00)00073-8 Occurrence Handle1:CAS:528:DC%2BD3cXmvFSht7w%3D

    Article  PubMed  CAS  Google Scholar 

  102. T Buschmann O Potapova A Bar-Shira VN Ivanov SY Fuchs S Henderson VA Fried T Minamoto D Alarcon-Vargas MR Pincus WA Gaarde NJ Holbrook Y Shiloh Z Ronai (2001) ArticleTitleJun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress Mol Cell Biol 21 2743–2754 Occurrence Handle11283254 Occurrence Handle10.1128/MCB.21.8.2743-2754.2001 Occurrence Handle1:CAS:528:DC%2BD3MXisVyhsb0%3D

    Article  PubMed  CAS  Google Scholar 

  103. HH Li AG Li HM Sheppard X Liu (2004) ArticleTitlePhosphorylation on Thr-55 by TAF1 mediates degradation of p53: a role for TAF1 in cell G1 progression Mol Cell 13 867–878 Occurrence Handle15053879 Occurrence Handle10.1016/S1097-2765(04)00123-6 Occurrence Handle1:CAS:528:DC%2BD2cXjtFajsrY%3D

    Article  PubMed  CAS  Google Scholar 

  104. Y Higashimoto S Saito XH Tong A Hong K Sakaguchi E Appella CW Anderson (2000) ArticleTitleHuman p53 is phosphorylated on serines 6 and 9 in response to DNA damage-inducing agents J Biol Chem 275 23199–231203 Occurrence Handle10930428 Occurrence Handle10.1074/jbc.M002674200 Occurrence Handle1:CAS:528:DC%2BD3cXltlGqtrg%3D

    Article  PubMed  CAS  Google Scholar 

  105. T Buschmann V Adler E Matusevich SY Fuchs Z Ronai (2000) ArticleTitlep53 phosphorylation and association with murine double minute 2, c-Jun NH2-terminal kinase, p14ARF, and p300/CBP during the cell cycle and after exposure to ultraviolet irradiation Cancer Res 60 896–900 Occurrence Handle10706102 Occurrence Handle1:CAS:528:DC%2BD3cXhs1Shsro%3D

    PubMed  CAS  Google Scholar 

  106. C Prives PA Hall (1999) ArticleTitleThe p53 pathway J Pathol 187 112–126 Occurrence Handle10341712 Occurrence Handle10.1002/(SICI)1096-9896(199901)187:1<112::AID-PATH250>3.0.CO;2-3 Occurrence Handle1:CAS:528:DyaK1MXmvVKrtQ%3D%3D

    Article  PubMed  CAS  Google Scholar 

  107. JP Blaydes MG Luciani S Pospisilova HM Ball B Vojtesek TR Hupp (2001) ArticleTitleStoichiometric phosphorylation of human p53 at Ser315 stimulates p53-dependent transcription J Biol Chem 276 4699–4708 Occurrence Handle11078726 Occurrence Handle10.1074/jbc.M003485200 Occurrence Handle1:CAS:528:DC%2BD3MXhtlOqtrk%3D

    Article  PubMed  CAS  Google Scholar 

  108. GJ Milczarek J Martinez GT Bowden (1997) ArticleTitlep53 Phosphorylation: biochemical and functional consequences Life Sci 60 1–11 Occurrence Handle8995526 Occurrence Handle10.1016/S0024-3205(96)00479-1 Occurrence Handle1:CAS:528:DyaK28XnsV2mt70%3D

    Article  PubMed  CAS  Google Scholar 

  109. M Hao AM Lowy M Kapoor A Deffie G Liu G Lozano (1996) ArticleTitleMutation of phosphoserine 389 affects p53 function in vivo J Biol Chem 271 29380–29385 Occurrence Handle8910602 Occurrence Handle10.1074/jbc.271.46.29380 Occurrence Handle1:CAS:528:DyaK28XntFKrt7o%3D

    Article  PubMed  CAS  Google Scholar 

  110. TR Hupp DP Lane (1995) ArticleTitleTwo distinct signaling pathways activate the latent DNA binding function of p53 in a casein kinase II-independent manner J Biol Chem 270 18165–18174 Occurrence Handle7629129 Occurrence Handle10.1074/jbc.270.30.18165 Occurrence Handle1:CAS:528:DyaK2MXnt1Cqs7s%3D

    Article  PubMed  CAS  Google Scholar 

  111. M Matsumoto M Furihata A Kurabayashi Y Ohtsuki (2004) ArticleTitlePhosphorylation state of tumor-suppressor gene p53 product overexpressed in skin tumors Oncol Rep 12 1039–1043 Occurrence Handle15492790 Occurrence Handle1:CAS:528:DC%2BD2cXhtVWksLvP

    PubMed  CAS  Google Scholar 

  112. M Matsumoto M Furihata A Kurabayashi S Sasaguri K Araki H Hayashi Y Ohtsuki (2004) ArticleTitlePrognostic significance of serine 392 phosphorylation in overexpressed p53 protein in human esophageal squamous cell carcinoma Oncology 67 143–150 Occurrence Handle15539919 Occurrence Handle10.1159/000081001 Occurrence Handle1:CAS:528:DC%2BD2cXpslWitL8%3D

    Article  PubMed  CAS  Google Scholar 

  113. M Furihata A Kurabayashi M Matsumoto H Sonobe Y Ohtsuki N Terao M Kuwahara T Shuin (2002) ArticleTitleFrequent phosphorylation at serine 392 in overexpressed p53 protein due to missense mutation in carcinoma of the urinary tract J Pathol 197 82–88 Occurrence Handle12081208 Occurrence Handle10.1002/path.1082 Occurrence Handle1:CAS:528:DC%2BD38Xkt1SgtLY%3D

    Article  PubMed  CAS  Google Scholar 

  114. PN Friedman X Chen J Bargonetti C Prives (1993) ArticleTitleThe p53 protein is an unusually shaped tetramer that binds directly to DNA Proc Natl Acad Sci USA 90 3319–3323 Occurrence Handle8475074 Occurrence Handle10.1073/pnas.90.8.3319 Occurrence Handle1:CAS:528:DyaK3sXkt1eisr8%3D

    Article  PubMed  CAS  Google Scholar 

  115. TD Halazonetis AN Kandil (1993) ArticleTitleConformational shifts propagate from the oligomerization domain of p53 to its tetrameric DNA binding domain and restore DNA binding to select p53 mutants EMBO J 12 5057–5064 Occurrence Handle8262048 Occurrence Handle1:CAS:528:DyaK2cXitlyntbc%3D

    PubMed  CAS  Google Scholar 

  116. JA Pietenpol T Tokino S Thiagalingam WS el-Deiry KW Kinzler B Vogelstein (1994) ArticleTitleSequence-specific transcriptional activation is essential for growth suppression by p53 Proc Natl Acad Sci USA 91 1998–2002 Occurrence Handle8134338 Occurrence Handle10.1073/pnas.91.6.1998 Occurrence Handle1:CAS:528:DyaK2cXivFWgs7c%3D

    Article  PubMed  CAS  Google Scholar 

  117. KG McLure PW Lee (1998) ArticleTitleHow p53 binds DNA as a tetramer EMBO J 17 3342–3350 Occurrence Handle9628871 Occurrence Handle10.1093/emboj/17.12.3342 Occurrence Handle1:CAS:528:DyaK1cXksFCltL4%3D

    Article  PubMed  CAS  Google Scholar 

  118. I Herskowitz (1987) ArticleTitleFunctional interaction of genes by dominant negative mutations Nature (Lond) 329 212–222 Occurrence Handle10.1038/329212a0

    Article  Google Scholar 

  119. KV Chin K Ueda I Pastan MM Gottesman (1992) ArticleTitleModulation of activity of the promoter of the human MDR1 gene by Ras and p53 Science 255 459–462 Occurrence Handle1346476 Occurrence Handle1:CAS:528:DyaK38XhtVSmurw%3D

    PubMed  CAS  Google Scholar 

  120. D Dittmer S Pati G Zambetti S Chu AK Teresky M Moore C Finlay AJ Levine (1993) ArticleTitleGain of function mutations in p53 Nat Genet 4 42–46 Occurrence Handle8099841 Occurrence Handle10.1038/ng0593-42 Occurrence Handle1:CAS:528:DyaK3sXkt1ajsbo%3D

    Article  PubMed  CAS  Google Scholar 

  121. SP Deb RM Munoz DR Brown MA Subler S Deb (1994) ArticleTitleWild-type human p53 activates the human epidermal growth factor receptor promoter Oncogene 9 1341–1349 Occurrence Handle8152794 Occurrence Handle1:CAS:528:DyaK2cXkslGjtbY%3D

    PubMed  CAS  Google Scholar 

  122. A Lanyi D Deb RC Seymour JH Ludes-Meyers MA Subler S Deb (1998) ArticleTitle‘Gain of function’ phenotype of tumor-derived mutant p53 requires the oligomerization/nonsequence-specific nucleic acid-binding domain Oncogene 16 3169–3176 Occurrence Handle9671396 Occurrence Handle10.1038/sj.onc.1201857 Occurrence Handle1:CAS:528:DyaK1cXkt1OmurY%3D

    Article  PubMed  CAS  Google Scholar 

  123. MW Frazier X He J Wang Z Gu JL Cleveland GP Zambetti (1998) ArticleTitleActivation of c-myc gene expression by tumor-derived p53 mutants requires a discrete C-terminal domain Mol Cell Biol 18 3735–3743 Occurrence Handle9632756 Occurrence Handle1:CAS:528:DyaK1cXkt1Squ7s%3D

    PubMed  CAS  Google Scholar 

  124. X Yang A Pater SC Tang (1999) ArticleTitleCloning and characterization of the human BAG-1 gene promoter: upregulation by tumor-derived p53 mutants Oncogene 18 4546–4553 Occurrence Handle10467399 Occurrence Handle10.1038/sj.onc.1202843 Occurrence Handle1:CAS:528:DyaK1MXlslCrtbY%3D

    Article  PubMed  CAS  Google Scholar 

  125. RH Wenger M Gassmann (1997) ArticleTitleOxygen(es) and the hypoxia-inducible factor Biol Chem 378 609–616 Occurrence Handle1:CAS:528:DyaK2sXlt1ags7o%3D

    CAS  Google Scholar 

  126. ME Cockman N Masson DR Mole P Jaakkola GW Chang SC Clifford ER Maher CW Pugh PJ Ratcliffe PH Maxwell (2000) ArticleTitleHypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel–Lindau tumor suppressor protein J Biol Chem 275 25733–25741 Occurrence Handle10823831 Occurrence Handle10.1074/jbc.M002740200 Occurrence Handle1:CAS:528:DC%2BD3cXmtVeht7o%3D

    Article  PubMed  CAS  Google Scholar 

  127. M Furihata H Sonobe Y Ohtsuki (1995) ArticleTitleThe aberrant p53 protein Int J Oncol 6 1209–1226 Occurrence Handle1:CAS:528:DyaK2MXmslSrsrk%3D

    CAS  Google Scholar 

  128. A Kanamoto H Kato Y Tachimori H Watanabe Y Nakanishi H Kondo H Yamaguchi T Gotoda K Muro Y Matsumura (1999) ArticleTitleNo prognostic significance of p53 expression in esophageal squamous cell carcinoma J Surg Oncol 72 94–98 Occurrence Handle10518106 Occurrence Handle10.1002/(SICI)1096-9098(199910)72:2<94::AID-JSO10>3.0.CO;2-9 Occurrence Handle1:STN:280:DyaK1MvkslymtA%3D%3D

    Article  PubMed  CAS  Google Scholar 

  129. M Sarbia R Porschen F Borchard O Horstmann R Willers HE Gabbert (1994) ArticleTitlep53 protein expression and prognosis in squamous cell carcinoma of the esophagus Cancer (Phila) 74 2218–2223 Occurrence Handle10.1002/1097-0142(19941015)74:8<2218::AID-CNCR2820740803>3.0.CO;2-2 Occurrence Handle1:STN:280:ByqD3cjjsFQ%3D

    Article  CAS  Google Scholar 

  130. T Tsujinaka H Shiozaki M Yamamoto M Inoue M Yano Y Doki M Monden (1999) ArticleTitleRole of preoperative chemoradiation in the management of upper third thoracic esophageal squamous cell carcinoma Am J Surg 177 503–506 Occurrence Handle10414703 Occurrence Handle10.1016/S0002-9610(99)00103-8 Occurrence Handle1:STN:280:DyaK1MzktFKluw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  131. M Gostissa A Hengstermann V Fogal P Sandy SE Schwarz M Scheffner G Del Sal (1999) ArticleTitleActivation of p53 by conjugation to the ubiquitin-like protein SUMO-1 EMBO J 18 6462–6471 Occurrence Handle10562558 Occurrence Handle10.1093/emboj/18.22.6462 Occurrence Handle1:CAS:528:DyaK1MXns1Ort78%3D

    Article  PubMed  CAS  Google Scholar 

  132. P Shaw J Freeman R Bovey R Iggo (1996) ArticleTitleRegulation of specific DNA binding by p53: evidence for a role for O-glycosylation and charged residues at the carboxy-terminus Oncogene 12 921–930 Occurrence Handle8632915 Occurrence Handle1:CAS:528:DyaK28XhsVKnsrc%3D

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Clinical Laboratory, Kochi Medical School Hospital, Nankoku, Kochi, 783-8305, Japan

    Manabu Matsumoto

  2. Department of Tumor Pathology, Kochi Medical School, Kochi University, Kochi, Japan

    Mutsuo Furihata & Yuji Ohtsuki

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  1. Manabu Matsumoto
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Correspondence to Manabu Matsumoto.

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Matsumoto, M., Furihata, M. & Ohtsuki, Y. Posttranslational phosphorylation of mutant p53 protein in tumor development. Med Mol Morphol 39, 79–87 (2006). https://doi.org/10.1007/s00795-006-0320-0

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