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Cultivable fungi present in deep-sea sediments of Antarctica: taxonomy, diversity, and bioprospecting of bioactive compounds

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Abstract

We accessed the culturable mycobiota present in marine sediments at different depths in Antarctica Ocean. Acremonium fusidioides, Penicillium allii-sativi, Penicillium chrysogenum, Penicillium palitans, Penicillium solitum, and Pseudogymnoascus verrucosus were identified. Penicillium allii-sativi was the dominant species. At least one isolate of each species was capable to present antifungal, trypanocidal, leishmanicidal, antimalarial, nematocidal, or herbicidal activities. Penicillium produced extracts with strong trypanocidal and antimalarial activities, and the extracts of P. solitum and P. chrysogenum demonstrated strong antimalarial activities. Acremonium fusidioides and P. verrucosus displayed strong selective herbicidal properties. The 1H NMR signals for extracts of A. fusidioides, P. chrysogenum, and P. solitum indicated the presence of highly functionalized secondary metabolites, which may be responsible for the biological activities detected. In the deep marine Antarctic sediments, we detected fungal assemblages in which the Penicillium species were found to be dominant and demonstrated capabilities to survive and/or colonise that poly-extreme habitat. Penicillium being a polyextremophile Antarctic species, exhibited strong biological activities and the presence of aromatic compounds in its extracts may indicate that they are wild ancient strains with high genetic and biochemical potentials that enable them to produce bioactive compounds which can be researched in further studies and used in the chemotherapy of neglected tropical diseases as well as in agriculture.

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Acknowledgements

We acknowledge the financial support from CNPq PROANTAR 442258/2018-6, INCT Criosfera II, CNPq, FAPEMIG, and FNDCT. This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brasil (CAPES)—Finance Code 001. We are thankful to the Laboratório de Ressonância Magnética Nuclear de Alta Resolução (LAREMAR/UFMG) and IS Lula for the NMR experiments. The authors thank the Program for Technological Development of Tools for Health-PDTIS-Fiocruz for use of its facilities (Bioprospection and Chagas disease-PlaBio Tc platforms). PASJ is research fellow supported by Programa de Pós-graduação em Ciências da Saúde, Fiocruz Minas (CAPES/PNPD).

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  1. Departamento de Microbiologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, CEP-31270-901, Brasil

    Mayara B. Ogaki, Lívia C. Coelho, Roberta O. Viana, Viviane S. Alves & Luiz H. Rosa

  2. Instituto de Geociências, Universidade Federal Fluminense, Niterói, RJ, Brasil

    Rosemary Vieira & Arthur A. Neto

  3. Instituto René Rachou, FIOCRUZ-Minas, Belo Horizonte, MG, Brasil

    Carlos L. Zani, Tânia M. A. Alves, Policarpo A. S. Junior, Silvane M. F. Murta, Emerson C. Barbosa, Jaquelline G. Oliveira, Isabela P. Ceravolo, Patrícia O. Pereira & Betania B. Cota

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  1. Mayara B. Ogaki
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Ogaki, M.B., Coelho, L.C., Vieira, R. et al. Cultivable fungi present in deep-sea sediments of Antarctica: taxonomy, diversity, and bioprospecting of bioactive compounds. Extremophiles 24, 227–238 (2020). https://doi.org/10.1007/s00792-019-01148-x

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