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Prognostic value of non-smoking, non-alcohol drinking status in oral cavity cancer

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Abstract

Objectives

To compare the treatment response and prognosis of oral cavity cancer between non-smoking and non-alcohol-drinking (NSND) patients and smoking and alcohol-drinking (SD) patients.

Methods

A total of 313 consecutively treated patients from 2000 to 2019 were included. Demographic, clinicopathologic, treatment, and prognosis information were obtained. Relapse-free survival (RFS), disease-specific survival (DSS), and overall survival (OS) were compared between NSND and SD groups using Kaplan-Meier plots, log-rank test, and multivariate Cox regression analysis.

Results

Sample prevalence of NSND patients was 54.6%. These patients were predominantly females in their eighth decade with lower prevalence of floor of the mouth cancers compared to SD patients (1.8% vs 14.8%). No difference in the RFS and DSS between both groups was found following multivariable analysis; however, NSND patients had better OS (HR (95% CI) − 0.47 (0.29–0.75); p = 0.002). Extracapsular extension was associated with significantly poorer OS, DSS, and RFS in this oral cavity cancer cohort.

Conclusion

Treatment response and disease-specific prognosis are comparable between NSND and SD patients with oral cavity cancer. However, NSND patients have better OS.

Clinical relevance

This study shows that oral cavity cancer in NSND is not less or more aggressive compared to SD patients. Although better survival is expected for NSND than SD patients, this is likely due to the reduced incidence of other chronic diseases in the NSND group.

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Author information

Authors and Affiliations

  1. Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Hong Kong, Hong Kong SAR, China

    John Adeoye, Liuling Hui, Jia Yan Tan, Siu-Wai Choi & Peter Thomson

  2. Oral Cancer Research Group, Faculty of Dentistry, University of Hong Kong, Hong Kong SAR, China

    John Adeoye, Jia Yan Tan, Siu-Wai Choi & Peter Thomson

  3. Applied Oral Sciences and Community Dental Care, University of Hong Kong, Hong Kong SAR, China

    Mohamad Koohi-Moghadam

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  1. John Adeoye
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  2. Liuling Hui
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  5. Siu-Wai Choi
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  6. Peter Thomson
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Corresponding author

Correspondence to John Adeoye.

Ethics declarations

Ethics approval

Approval to conduct this study was granted by the Institutional Review Board of the University of Hong Kong/Hospital Authority Hong Kong West Cluster (Reference number UW-19-704). All clinical data were anonymized by the researchers, and all potential patient identifiers were removed before data analysis.

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For this type of study, formal consent is not required.

Conflict of interest

JA declares that he has no conflict of interest. LH declares that she has no conflict of interest. JYT declares that she has no conflict of interest. MK-M declares that he has no conflict of interest. S-WC declares that she has no conflict of interest. PT declares that he has no conflict of interest.

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Adeoye, J., Hui, L., Tan, J.Y. et al. Prognostic value of non-smoking, non-alcohol drinking status in oral cavity cancer. Clin Oral Invest 25, 6909–6918 (2021). https://doi.org/10.1007/s00784-021-03981-x

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  • DOI: https://doi.org/10.1007/s00784-021-03981-x

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