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Is there an association between rheumatoid arthritis and bone changes in the temporomandibular joint diagnosed by cone-beam computed tomography? A systematic review and meta-analysis

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Abstract

Objectives

Evaluate the relation of rheumatoid arthritis (RA) and bone changes in the temporomandibular joint diagnosed by cone-beam computed tomography (CBCT).

Materials and methods

This systematic review and meta-analysis were recorded in the PROSPERO database, using the CRD42020153246 protocol. The electronic searches were performed in the following databases: Pubmed, Scopus, Web of Science, Lilacs, Cochrane, and Open Grey. Cross-sectional studies that evaluated patients with RA with bone changes in the temporomandibular joint diagnosed by CBCT, without language restriction or publication date, were included. Meta-analysis was performed in Stata Software (StataCorp, TX, USA, version 12.0), using the metan, and a random effects model, and the risk of different bone alterations occurring in adults with and without arthritis was estimated using odds ratios (ORs) as a pooled measure of effect. Forest plots were used to present the isolated and the pooled effects (ORs and 95% CI).

Results

Six studies were used for qualitative synthesis and 2 studies for quantitative synthesis. All studies diagnosed higher prevalence changes in the bone structures of the TMJ of RA patients, described as erosion, flattening, sclerosis, and osteophytes. Meta-analysis showed that the chance of bone changes occurring in components of the TMJ is greater in individuals who have RA.

Conclusion

There is an association between RA and bone changes in TMJ structures diagnosed through CBCT, as RA patients were more likely to have osteoarthritic changes in this joint.

Clinical relevance

Understanding the existence of an association between bone alterations in TMJ and RA can assist in the management of patients.

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Authors and Affiliations

  1. Post Graduate Program in Dentistry, Federal University of Paraíba, João Pessoa, Paraíba, Brazil

    Débora e Silva Campos, Isis de Araújo Ferreira Muniz & Natália Lins de Souza Villarim

  2. Department of Social Medicine. Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil

    Isabella Lima Arrais Ribeiro

  3. Department of Restorative Dentistry, Federal University of Paraíba, João Pessoa, Paraíba, Brazil

    André Ulisses Dantas Batista

  4. Department of Clinical and Social Dentistry, Federal University of Paraíba, João Pessoa, Paraíba, Brazil

    Paulo Rogério Ferreti Bonan & Marcelo Augusto Oliveira de Sales

Authors
  1. Débora e Silva Campos
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  2. Isis de Araújo Ferreira Muniz
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  3. Natália Lins de Souza Villarim
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  4. Isabella Lima Arrais Ribeiro
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  5. André Ulisses Dantas Batista
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  6. Paulo Rogério Ferreti Bonan
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  7. Marcelo Augusto Oliveira de Sales
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Contributions

Campos DS, Muniz IAF, Villarim NLS, Batista AUD, Bonan PRF, and Sales MAO worked on conception, design of the work, acquisition, and interpretation of data for the work. Drafting the work, revising it critically, and final approval of the version to be published. Ribeiro ILA worked on the acquisition, analysis, and interpretation of data for the work.

Corresponding author

Correspondence to Débora e Silva Campos.

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Campos, D.e.S., de Araújo Ferreira Muniz, I., de Souza Villarim, N.L. et al. Is there an association between rheumatoid arthritis and bone changes in the temporomandibular joint diagnosed by cone-beam computed tomography? A systematic review and meta-analysis. Clin Oral Invest 25, 2449–2459 (2021). https://doi.org/10.1007/s00784-021-03817-8

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  • DOI: https://doi.org/10.1007/s00784-021-03817-8

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