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Do resin-based composite CAD/CAM blocks release monomers?

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Abstract

Objective

The present study aimed to identify and quantify the elution of monomers of five different resin-based CAD/CAM blocks (RCBs) using HPLC.

Methods

Five different RCBs were used in the study: GC Cerasmart (CS), Voco Grandio blocs (GR), 3M Lava Ultimate (LU), Shofu Block (SB), and Vita Enamic (VE). Fifteen samples from each material were prepared using a low-speed precision diamond saw (ISOMET Buehler, Lake Bluff, IL, USA) at 5 × 5 × 4 mm size. After the preparation of samples, an extraction solution was mixed with %75/%25 ethanol/water. The samples were stored in the amber-colored bottles during three different immersed periods as 1 h, 24 h, and 90 days (n = 5). After immersion, 0.5 ml solutions were taken from each bottle and analyzed using HPLC.

Results

A total of 16.7 μg/ml of monomers from SB, 13.4 μg/ml of monomers from GR, 13.2 μg/ml of monomers from CS, and 6.7 μg/ml of monomers from LU were found after 3-m immersion. TEGDMA after 3-m of immersion was only released from the SB group, and also BisEMA was released from the CS group. Among the specimens immersed for 1 h, UDMA was released the least from the LU group and the most from the GR group (p < 0.05). Correspondingly, 24 h and 3 m after immersion, the highest release of monomers was found in the GR (p < 0.05).

Conclusions

When the monomer release from RCBs was evaluated, it was shown that these materials released methacrylate-based monomers except VE, especially if they were kept in a solvent solution for a long time such as 3 m.

Clinical significance

The novel resin-based CAD/CAM blocks might monomer release, which may cause cytotoxic effects. But, the detected amount of monomer release is below the estimated daily limit.

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Acknowledgments

The authors do not have any financial interest in the companies whose materials are included in this article. The authors thank Voco for obtaining their products.

Funding

This work was supported by The Scientific and Technological Research Council of Turkey (TUBITAK), (grant number: 216S723).

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Authors and Affiliations

  1. Department of Prosthetic Dentistry, Faculty of Dentistry, Akdeniz University, 07058, Antalya, Turkey

    Kubilay Barutcigil

  2. Department of Restorative Dentistry, Faculty of Dentistry, Akdeniz University, 07058, Antalya, Turkey

    Ayşe Dündar, Sevde Gül Batmaz, Kardelen Yıldırım & Çağatay Barutçugil

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Correspondence to Çağatay Barutçugil.

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Barutcigil, K., Dündar, A., Batmaz, S.G. et al. Do resin-based composite CAD/CAM blocks release monomers?. Clin Oral Invest 25, 329–336 (2021). https://doi.org/10.1007/s00784-020-03377-3

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