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Lipid parameters in obese and normal weight patients with or without chronic periodontitis

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Abstract

Objective

The aim of this study was to evaluate the serum levels of lipids in patients with normal weight (NW) or obesity with or without chronic periodontitis (ChP).

Materials and methods

One hundred and sixty non-smoking patients without history of diabetes and/or cardiovascular events were allocated into one of the following groups: NW patients with periodontal health (NWH; n = 40), NW patients with ChP (NWChP; n = 40), obese patients with periodontal health (ObH; n = 40), and obese patients with ChP (ObChP; n = 40). Serum levels of total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglycerides (TRG) were estimated.

Results

After adjustments for gender and age, both NW groups presented lower levels of TRG than both obese groups (p < 0.05). The NWH group presented lower levels of LDL than both periodontitis groups (p < 0.05) and the lowest TC/HDL ratio when compared to the other groups (p < 0.05). Females from the NWH group exhibited higher levels of HDL and lower LDL/HDL ratio than females from the ObChP group (p < 0.05). Furthermore, individuals from the ObChP group were more likely to have levels of LDL ≥130 mg/dl and HDL ≤40 mg/dl, compared to those from the NWH group (p < 0.05).

Conclusions

ChP and obesity, jointly or individually, are associated with undesirable pro-atherogenic lipid profiles.

Clinical relevance

There is interest in identifying clinical conditions associated with dyslipidemia to improve preventive and treatment strategies. This study demonstrated that ChP, obesity, and the association of both conditions might be related to pro-atherogenic lipid profiles.

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Authors and Affiliations

  1. Department of Periodontology, Guarulhos University, São Paulo, Brazil

    Eduardo Zaccarias Cury, Vanessa Renata Santos, Suellen da Silva Maciel, Tiago Eduardo Dias Gonçalves, Glaucia Santos Zimmermann, Luciene Cristina Figueiredo & Poliana Mendes Duarte

  2. Department of Dentistry, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil

    Tiago Eduardo Dias Gonçalves

  3. Department of Statistics and Applied Mathematics, Federal University of Ceará, Fortaleza, Ceará, Brazil

    Rosa Maria Salani Mota

Authors
  1. Eduardo Zaccarias Cury
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  2. Vanessa Renata Santos
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  3. Suellen da Silva Maciel
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  4. Tiago Eduardo Dias Gonçalves
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  5. Glaucia Santos Zimmermann
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  6. Rosa Maria Salani Mota
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  7. Luciene Cristina Figueiredo
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  8. Poliana Mendes Duarte
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Corresponding author

Correspondence to Poliana Mendes Duarte.

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Conflict of interest

The authors declare that they have no conflict of interest.

Funding

The work was partially supported by the São Paulo State Research Foundation (São Paulo, São Paulo, Brazil; #2010/01930-3).

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This study protocol was previously approved by Guarulhos University’s Ethics Committee in Clinical Research (SISNEP 417-33/2009).

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Cury, E.Z., Santos, V.R., Maciel, S.d.S. et al. Lipid parameters in obese and normal weight patients with or without chronic periodontitis. Clin Oral Invest 22, 161–167 (2018). https://doi.org/10.1007/s00784-017-2095-1

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  • DOI: https://doi.org/10.1007/s00784-017-2095-1

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