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Effect of alendronate and intermittent parathyroid hormone on implant fixation in ovariectomized rats

  • Original Article
  • Published:
Journal of Orthopaedic Science

Abstract

Background

Intermittent administration of parathyroid hormone (PTH) leads to bone formation by increasing osteoblast numbers and activity levels. Animal studies have shown that intermittent PTH administration increases implant fixation in normal rats. The purpose of this study was to analyze the osseous incorporation of an implant in osteoporotic rats while treating them with intermittent PTH (1–34) or alendronate.

Methods

A total of 36 ovariectomized (OVX) Wistar rats were randomized into three groups. Polymethylmethacrylate cement rods were implanted in one tibia in each rat. The three groups received daily PTH (60 μg/kg body weight [BW]), alendronate (200 μg/kg BW), or saline (0.5 ml/kg BW). A sham-ovariectomized group (n = 12) was treated with saline. After 2 weeks, the area around the implants was analyzed by histomorphometry for bone volume density (BVD) and implant bone contact. Bone mineral density (BMD) was evaluated by dual-energy X-ray absorptiometry.

Results

The BVD was higher in the specimens treated with PTH than in the other groups. PTH improved the BVD, BMD, and implant bone contact. Alendronate doubled the implant bone contact compared to the OVX and sham groups but did not improve BVD or BMD.

Conclusions

These findings confirm that intermittent PTH enhances implant fixation in osteoporotic bone. The clinical significance of these findings is that application of intermittent PTH may be beneficial for early implant fixation in fractures, nonunions, and prosthetic replacements when bone density is decreased.

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Authors and Affiliations

  1. Department of Orthopedic Surgery, University Hospital Rostock, 142 Doberaner Strasse, Rostock, D-18057, Germany

    R. Skripitz & H. R. Johansson

  2. Rubin Institute for Advanced Orthopedics, Center for Joint Preservation and Reconstruction, Sinai Hospital of Baltimore, Baltimore, MD, USA

    H. R. Johansson & S. D. Ulrich

  3. Department of Orthopedic Surgery, University Hospital Eppendorf, Hamburg, Germany

    A. Werner

  4. Section for Orthopedics and Sports Medicine, IKE, Faculty of Health Sciences, Linköping, Sweden

    P. Aspenberg

Authors
  1. R. Skripitz
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  2. H. R. Johansson
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  3. S. D. Ulrich
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  4. A. Werner
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  5. P. Aspenberg
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Skripitz, R., Johansson, H.R., Ulrich, S.D. et al. Effect of alendronate and intermittent parathyroid hormone on implant fixation in ovariectomized rats. J Orthop Sci 14, 138–143 (2009). https://doi.org/10.1007/s00776-008-1311-x

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  • DOI: https://doi.org/10.1007/s00776-008-1311-x

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