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Combination analysis of three polymorphisms for predicting the risk for steroid-induced osteonecrosis of the femoral head

  • Original Article
  • Published:
Journal of Orthopaedic Science

Abstract

Background

Osteonecrosis of the femoral head (ONF) often develops following corticosteroid administration. We previously investigated the genetic background for the development of corticosteroid-induced ONF and found relations between ONF development and genetic polymorphisms in the ATP binding cassette B1 (ABCB1) gene (C3435T), apolipoprotein B (ApoB) gene (C7623T), and cAMP-response element binding protein-binding protein (CBP) gene (rs3751845). In the present study, we examined whether combined information regarding these three single nucleotide polymorphisms (SNPs) in the ABCB1, ApoB, and CBP genes is useful for predicting ONF development.

Methods

A case-control study was performed to study the development of corticosteroid-induced ONF. The cases were 34 patients who developed ONF, and the references were 123 patients who did not develop ONF. To evaluate the presence of interactions among the ABCB1, ApoB, and CBP genes, a synergistic index was calculated using an additive model.

Results

The synergistic index between the ABCB1 and CBP genes was >1.00 (1.99), revealing the presence of an interaction.

Conclusions

Through analysis of multiple genes that may affect ONF development, we have shown a possible relation among genes encoding completely different proteins. We believe that analysis of the interactions among these genes can contribute to elucidating the mechanism of ONF development in addition to enabling identification of high-risk patients for ONF development.

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Authors and Affiliations

  1. Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan

    Masaaki Kuribayashi, Mikihiro Fujioka, Kenji A. Takahashi, Yuji Arai, Tetsurou Hirata & Toshikazu Kubo

  2. Department of Developmental Medicine (Pediatrics), Osaka University Graduate School of Medicine, Osaka, Japan

    Shigeo Nakajima

  3. Department of Transplantation and Regenerative Surgery, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan

    Norio Yoshimura

  4. Department of Biochemistry and Molecular Biology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan

    Yoshiko Satomi & Hoyoku Nishino

  5. Department of Public Health, Faculty of Medicine, Osaka City University, Osaka, Japan

    Kyoko Kondo, Wakaba Fukushima & Yoshio Hirota

Authors
  1. Masaaki Kuribayashi
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  2. Mikihiro Fujioka
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  3. Kenji A. Takahashi
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  4. Yuji Arai
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  5. Tetsurou Hirata
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  6. Shigeo Nakajima
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  7. Norio Yoshimura
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  8. Yoshiko Satomi
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  9. Hoyoku Nishino
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  10. Kyoko Kondo
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  11. Wakaba Fukushima
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  12. Yoshio Hirota
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  13. Toshikazu Kubo
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Cite this article

Kuribayashi, M., Fujioka, M., Takahashi, K.A. et al. Combination analysis of three polymorphisms for predicting the risk for steroid-induced osteonecrosis of the femoral head. J Orthop Sci 13, 297–303 (2008). https://doi.org/10.1007/s00776-008-1244-4

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  • DOI: https://doi.org/10.1007/s00776-008-1244-4

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