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Genetic association of a polymorphism of the cAMP-responsive element binding protein-binding protein with steroid-induced osteonecrosis after kidney transplantation

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Abstract

Nontraumatic osteonecrosis (ON) of the femoral head is known to be one of the major complications after organ transplantations. Although the precise mechanism is still uncertain, the administration of glucocorticoid (GC) has been considered to play an important role in the occurrence of ON. To elucidate the genetic factors involved in this pathogenesis, we analyzed single nucleotide polymorphisms (SNP) in the genes for the GC receptor (GR), CYP3A4, cAMP-responsive element binding protein-binding protein (CBP), and nuclear receptor co-activator 2 (NCoA2). Among the patients examined, A/G alleles of the CBP gene were demonstrated in 32.4% of those with ON, but in only 14.6% of those without ON (P = 0.018). No relationships were observed between the SNPs of GR, CYP3A4, and NCoA2 genes and the occurrence of ON. These results indicate that the genetic polymorphism of the CBP, which is one of the essential factors exerting the biological effects of GC, may affect susceptibility to steroid-induced ON in patients after renal transplantation.

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Authors and Affiliations

  1. Department of Pediatrics, Osaka University Graduate School of Medicine, 2-2-D5 Yamadaoka, Suita, Osaka, 565-0871, Japan

    Kyoko Tamura, Shigeo Nakajima & Keiichi Ozono

  2. Department of Public Health, Faculty of Medicine, Osaka City University, Osaka, Japan

    Yoshio Hirota

  3. Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan

    Kenji A. Takahashi, Mikihiro Fujioka & Toshikazu Kubo

  4. Division of Biomedical Informatics, Course of Health Science, Osaka University, Graduate School of Medicine, Suita, Japan

    Kyoko Tamura & Yoshinori Iwatani

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  1. Kyoko Tamura
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  2. Shigeo Nakajima
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  3. Yoshio Hirota
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  4. Kenji A. Takahashi
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  5. Mikihiro Fujioka
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  6. Toshikazu Kubo
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Correspondence to Shigeo Nakajima.

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Tamura, K., Nakajima, S., Hirota, Y. et al. Genetic association of a polymorphism of the cAMP-responsive element binding protein-binding protein with steroid-induced osteonecrosis after kidney transplantation. J Bone Miner Metab 25, 320–325 (2007). https://doi.org/10.1007/s00774-007-0770-z

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