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The role of zinc and its compounds in leukemia

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Abstract

Zinc is one of the most important microelements necessary for normal body functioning. Zinc is marked in numerous diseases and, hence, its properties and behavior in the body have long been a subject of extensive study. This review considers trends in the assessment of the role of zinc and its compounds in the past decade. It becomes evident that redox-inactive zinc is the main supervisor in the conformation of the most important molecules in all body organs and tissues. We placed emphasis on the variety of zinc-binding sites and the role of zinc in the genesis and progress of different forms of leukemia. The importance of some families of transcription factors in the development and prognosis of treatment of various leukemia forms is examined; new directions of these studies are shown.

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Authors and Affiliations

  1. Chemical Department, Lomonosov Moscow State University, 1, Bd. 3 Leninskie Gory, 119992, Moscow, Russia

    Alexey P. Orlov, Marina A. Orlova, Tatiana P. Trofimova & Stepan N. Kalmykov

  2. Biochemistry and Pharmacology Division, Dmitry Rogachev Medical National Research Center of Pediatric Hematology, Oncology and Immunology, 1, Samory Mashela st., 117997, Moscow, Russia

    Marina A. Orlova

  3. Department of Organic Synthesis, Institute of Physiological Active Compounds RAS, North pass., 1, Chernogolovka, 142432, Chernogolovka, Moscow, Russia

    Tatiana P. Trofimova

  4. Pirogov Russian National Research Medical University, 1, Ostrovityanova st., 117997, Moscow, Russia

    Dmitry A. Kuznetsov

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  1. Alexey P. Orlov
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  2. Marina A. Orlova
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Orlov, A.P., Orlova, M.A., Trofimova, T.P. et al. The role of zinc and its compounds in leukemia. J Biol Inorg Chem 23, 347–362 (2018). https://doi.org/10.1007/s00775-018-1545-9

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