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Recent advances in the epigenetics of bone metabolism

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Abstract

Osteoporosis is a common form of metabolic bone disease that is costly to treat and is primarily diagnosed on the basis of bone mineral density. As the influences of genetic lesions and environmental factors are increasingly studied in the pathological development of osteoporosis, regulated epigenetics are emerging as the important pathogenesis mechanisms in osteoporosis. Recently, osteoporosis genome-wide association studies and multi-omics technologies have revealed that susceptibility loci and the misregulation of epigenetic modifiers are key factors in osteoporosis. Over the past decade, extensive studies have demonstrated epigenetic mechanisms, such as DNA methylation, histone/chromatin modifications, and non-coding RNAs, as potential contributing factors in osteoporosis that affect disease initiation and progression. Herein, we review recent advances in epigenetics in osteoporosis, with a focus on exploring the underlying mechanisms and potential diagnostic/prognostic biomarker applications for osteoporosis.

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Author notes

  1. Yuexin Xu and Jing Ma contributed equally to this work.

Authors and Affiliations

  1. Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China

    Yuexin Xu & Duan Ma

  2. Department of Facial Plastic and Reconstructive Surgery, ENT Institute, Eye and ENT Hospital, Fudan University, Shanghai, China

    Jing Ma

  3. Department of Orthopedic Surgery, The Spine Surgical Center, Changzheng Hospital, Second Military Medical University, Shanghai, 20000, China

    Guohua Xu

Authors
  1. Yuexin Xu
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  2. Jing Ma
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  3. Guohua Xu
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  4. Duan Ma
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Correspondence to Guohua Xu or Duan Ma.

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Xu, Y., Ma, J., Xu, G. et al. Recent advances in the epigenetics of bone metabolism. J Bone Miner Metab 39, 914–924 (2021). https://doi.org/10.1007/s00774-021-01249-8

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