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Establishment of BMD reference databases for the diagnosis and evaluation of osteoporosis in central southern Chinese men

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Abstract

Osteoporosis in men is an increasingly important public health problem. This study was designed to establish bone mineral density (BMD) reference databases for central southern Chinese men at multiple skeletal sites. We recruited 2433 native Chinese males for BMD assessment. Of these, 1537 were healthy volunteers (age range, 15–85 years), and 896 were suspected to have osteoporosis. BMD values were measured at the posteroanterior (PA) and lateral spine, hip, and distal forearm using a Delphi A absorptiometer. The quadratic regression model provided the best fit for age-related changes in BMD in the spine and hip. The cubic regression model was the best for describing age-related BMD changes in the distal forearm. Peak BMD in the lumbar spine, femoral neck, and total hip occurred at 15–19 years. Peak BMD at the distal forearm occurred at 40–44 years. The prevalence of primary osteoporosis in subjects ranging from 50–85 years was 4.3%–27.7% at various skeletal sites. Compared to the databases established here, the Hologic databases led to significantly higher osteoporosis detection rates. The BMD reference databases established for central southern Chinese men provide the most reliable diagnostic standards for osteoporosis detection in men of central south China.

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References

  1. Cummings SR, Melton LJ (2002) Epidemiology and outcomes of osteoporotic fractures. Lancet 359:1761–1767

    Article  PubMed  Google Scholar 

  2. Kanis JA, Johnell O, Oden A, Sembo I, Redlund-Johnell I, Dawson A, De Laet C, Jonsson B (2000) Long-term risk of osteoporotic fracture in Malmo. Osteoporos Int 11:669–674

    Article  PubMed  CAS  Google Scholar 

  3. Baron JA, Karagas M, Barrett J, Kniffin W, Malenka D, Mayor M, Keller RB (1996) Basic epidemiology of fractures of the upper and lower limb among Americans over 65 years of age. Epidemiology 7:612–618

    Article  PubMed  CAS  Google Scholar 

  4. Johnell O, Gullberg B, Allander E, Kanis JA (1992) The apparent incidence of hip fracture in Europe: a study of national register sources. MEDOS Study Group. Osteoporos Int 2:298–302

    Article  PubMed  CAS  Google Scholar 

  5. Wehren LE, Hawkes WG, Orwig DL, Hebel JR, Zimmerman SI, Magaziner J (2003) Gender differences in mortality after hip fracture: the role of infection. J Bone Miner Res 18:2231–2237

    Article  PubMed  Google Scholar 

  6. Center JR, Bliuc D, Nguyen TV, Eisman JA (2007) Risk of subsequent fracture after low-trauma fracture in men and women. JAMA 297:387–394

    Article  PubMed  CAS  Google Scholar 

  7. Brunader R, Shelton DK (2002) Radiologic bone assessment in the evaluation of osteoporosis. Am Fam Physician 65:1357–1364

    PubMed  Google Scholar 

  8. Liu JM, Ning G, Chen JL (2007) Osteoporotic fractures in Asia: risk factors and strategies for prevention. J Bone Miner Metab 25:1–5

    Article  PubMed  Google Scholar 

  9. Vogel JM, Davis JW, Nomura A, Wasnich RD, Ross PD (1997) The effects of smoking on bone mass and the rates of bone loss among elderly Japanese-American men. J Bone Miner Res 12:1495–1501

    Article  PubMed  CAS  Google Scholar 

  10. Mitchell BD, Kammerer CM, Schneider JL, Perez R, Bauer RL (2003) Genetic and environmental determinants of bone mineral density in Mexican Americans: results from the San Antonio Family Osteoporosis Study. Bone (NY) 33:839–846

    Google Scholar 

  11. Wu XP, Liao EY, Huang G, Dai RC, Zhang H (2003) A comparison study of the reference curves of bone mineral density at different skeletal sites in native Chinese, Japanese, and American Caucasian women. Calcif Tissue Int 73:122–132

    Article  PubMed  CAS  Google Scholar 

  12. Deleze M, Cons-Molina F, Villa AR, Morales-Torres J, Gonzalez-Gonzalez JG, Calva JJ, Murillo A, Briceno A, Orozco J, Morales-Franco G, Pena-Rios H, Guerrero-Yeo G, Aguirre E, Elizondo J (2000) Geographic differences in bone mineral density of Mexican women. Osteoporos Int 11:562–569

    Article  PubMed  CAS  Google Scholar 

  13. McKay HA, Petit MA, Khan KM, Schutz RW (2000) Lifestyle determinants of bone mineral: a comparison between prepubertal Asian-and Caucasian-Canadian boys and girls. Calcif Tissue Int 66:320–324

    Article  PubMed  CAS  Google Scholar 

  14. Horlick M, Thornton J, Wang J, Levine LS, Fedun B, Pierson RN Jr (2000) Bone mineral in prepubertal children: gender and ethnicity. J Bone Miner Res 15:1393–1397

    Article  PubMed  CAS  Google Scholar 

  15. Nelson DA, Jacobsen G, Barondess DA, Parfitt AM (1995) Ethnic differences in regional bone density, hip axis length, and lifestyle variables among healthy black and white men. J Bone Miner Res 10:782–787

    Article  PubMed  CAS  Google Scholar 

  16. Lynn HS, Lau EM, Au B, Leung PC (2005) Bone mineral density reference norms for Hong Kong Chinese. Osteoporos Int 16: 1663–1668

    Article  PubMed  CAS  Google Scholar 

  17. Kelly TL (1992) Study protocol QDR reference databases. Hologic, Bedford, MA

    Google Scholar 

  18. Bonnick SL, Johnston CC Jr, Kleerekoper M, Lindsay R, Miller P, Sherwood L, Siris E (2001) Importance of precision in bone density measurements. J Clin Densitom 4:105–110

    Article  PubMed  CAS  Google Scholar 

  19. Liu Z, Piao J, Pang L, Qing X, Nan S, Pan Z, Guo Y, Wang X, Li F, Liu J, Cheng X (2002) The diagnostic criteria for primary osteoporosis and the incidence of osteoporosis in China. J Bone Miner Metab 20:181–189

    Article  PubMed  Google Scholar 

  20. Kelly TL (1990) Bone mineral density databases for American men and women. J Bone Miner Res 5(suppl 2):S249

    Google Scholar 

  21. Liao EY, Wu XP, Deng XG, Huang G, Zhu XP, Long ZF, Wang WB, Tang WL, Zhang H (2002) Age-related bone mineral density, accumulated bone loss rate and prevalence of osteoporosis at multiple skeletal sites in Chinese women. Osteoporos Int 13:669–1676

    Article  PubMed  Google Scholar 

  22. Wu XP, Liao EY, Zhang H, Shan PF, Cao XZ, Liu SP (2004) Establishment of BMD reference plots and determination of peak BMD at multiple skeletal regions in mainland Chinese women and the diagnosis of osteoporosis. Osteoporos Int 15:71–79

    Article  PubMed  Google Scholar 

  23. Liao EY, Wu XP, Luo XH, Zhang H, Dai RC, Huang G, Wang WB (2003) Establishment and evaluation of bone mineral density reference databases appropriate for diagnosis and evaluation of osteoporosis in Chinese women. J Bone Miner Metab 21:184–192

    Article  PubMed  Google Scholar 

  24. Zhang ZL, Qin YJ, Huang QR, Hu YQ, Li M, He JW, Zhang H, Liu YJ, Hu WW (2006) Bone mineral density of the spine and femur in healthy Chinese men. Asian J Androl 8:419–427

    Article  PubMed  Google Scholar 

  25. WHO (1994) Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. Report of a WHO Study Group. WHO Tech Rep Ser 843:1–29

    Google Scholar 

  26. Kanis JA, Gluer CC (2000) An update on the diagnosis and assessment of osteoporosis with densitometry. Committee of Scientific Advisors, International Osteoporosis Foundation. Osteoporos Int 11:192–202

    Article  PubMed  CAS  Google Scholar 

  27. Kamel HK (2005) Male osteoporosis: new trends in diagnosis and therapy. Drugs Aging 22:741–748

    Article  PubMed  CAS  Google Scholar 

  28. Kanis JA, Johnell O, Oden A, Johansson H, Eisman JA, Fujiwara S, Kroger H, Honkanen R, Melton LJ III, O’Neill T, Reeve J, Silman A, Tenenhouse A (2006) The use of multiple sites for the diagnosis of osteoporosis. Osteoporos Int 17:527–534

    Article  PubMed  CAS  Google Scholar 

  29. Melton LJ III, Atkinson EJ, O’Connor MK, O’Fallon WM, Riggs BL (1998) Bone density and fracture risk in men. J Bone Miner Res 13:1915–1923

    Article  PubMed  Google Scholar 

  30. Looker AC, Orwoll ES, Johnston CC Jr, Lindsay RL, Wahner HW, Dunn WL, Calvo MS, Harris TB, Heyse SP (1997) Prevalence of low femoral bone density in older U.S. adults from NHANES III. J Bone Miner Res 12:1761–1768

    Article  PubMed  CAS  Google Scholar 

  31. Kanis JA, Johnell O, Oden A, Jonsson B, De Laet C, Dawson A (2000) Risk of hip fracture according to World Health Organization criteria for osteopenia and osteoporosis. Bone (NY) 27: 585–590

    CAS  Google Scholar 

  32. Krassas GE, Papadopoulou FG, Doukidis D, Konstantinidis TH, Kalothetou K (2001) Age-related changes in bone density among healthy Greek males. J Endocrinol Invest 24:326–333

    PubMed  CAS  Google Scholar 

  33. Maalouf G, Salem S, Sandid M, Attallah P, Eid J, Saliba N, Nehme I, Johnell O (2000) Bone mineral density of the Lebanese reference population. Osteoporos Int 11:756–764

    Article  PubMed  CAS  Google Scholar 

  34. Anonymous (1996) Guidelines for the early detection of osteoporosis and prediction of fracture risk. Council of the National Osteoporosis Foundation. S Afr Med J 86:1113–1116

  35. Orimo H, Hayashi Y, Fukunaga M, Sone T, Fujiwara S, Shiraki M, Kushida K, Miyamoto S, Soen S, Nishimura J, Oh-Hashi Y, Hosoi T, Gorai I, Tanaka H, Igai T, Kishimoto H; Osteoporosis Diagnostic Criteria Review Committee: Japanese Society for Bone and Mineral Research (2001) Diagnostic criteria for primary osteoporosis: year 2000 revision. J Bone Miner Metab 19:331–337

    Article  PubMed  CAS  Google Scholar 

  36. Hongsdusit N, von Muhlen D, Barrett-Connor E (2006) A comparison between peripheral BMD and central BMD measurements in the prediction of spine fractures in men. Osteoporos Int 17:872–877

    Article  PubMed  CAS  Google Scholar 

  37. Fujiwara S (2004) Epidemiology of osteoporosis and fracture (in Japanese). Clin Calcium 14:13–18

    PubMed  Google Scholar 

  38. Faulkner KG, Orwoll E (2002) Implications in the use of T-scores for the diagnosis of osteoporosis in men. J Clin Densitom 5:87–93

    Article  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Institute of Metabolism and Endocrinology, The Second Xiang-Ya Hospital, Central South University, Changsha, 139 Renmin-Zhong Road, Hunan, 410011, China

    Xian-Ping Wu, Yan-Li Hou, Hong Zhang, Peng-Fei Shan, Qin Zhao, Xing-Zhi Cao, Ru-Chun Dai, Xiang-Hang Luo & Er-Yuan Liao

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  1. Xian-Ping Wu
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  2. Yan-Li Hou
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  3. Hong Zhang
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  4. Peng-Fei Shan
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  9. Er-Yuan Liao
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Correspondence to Er-Yuan Liao.

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Wu, XP., Hou, YL., Zhang, H. et al. Establishment of BMD reference databases for the diagnosis and evaluation of osteoporosis in central southern Chinese men. J Bone Miner Metab 26, 586–594 (2008). https://doi.org/10.1007/s00774-008-0877-x

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  • DOI: https://doi.org/10.1007/s00774-008-0877-x

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