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Genotypes and clinical aspects associated with bone mineral density in Argentine postmenopausal women

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Abstract

The aim of this study was to determine genotypes and clinical aspects associated with bone mineral density (BMD) in postmenopausal women from Córdoba, Argentina. Polymorphisms were assessed by RFLP-PCR technique using BsmI and FokI for vitamin D receptor gene (VDR) and XbaI and PvuII for estrogen receptor-α gene (ERα) as restrictases. Sixty-eight healthy, 54 osteopenic, and 64 osteoporotic postmenopausal women were recruited. Femoral neck and lumbar spine BMD were inversely correlated with age in the entire analyzed population. Height was lower in osteopenic and osteoporotic women as compared to healthy women (P < 0.05). Weight and body mass index (BMI) were the lowest in osteoporotic women (P < 0.01 versus healthy group). Serum procollagen type I Nterminal propeptide (PINP) was higher in osteoporotic women as compared to the other groups. Distribution of VDR and ERα genotypes was similar in the three groups. Genotype bb (VDR) was associated with low values of lumbar BMD in the healthy group (P < 0.05 versus genotype Bb), and with low values of femoral BMD (P < 0.05 versus genotype BB) in osteoporotic women. BB*Pp interaction was associated with the highest femoral neck BMD (P < 0.05), whereas the bb*xx interaction was associated with the lowest femoral neck BMD in the total population analyzed (P < 0.05). In conclusion, parameters such as age, height, weight, BMI, serum PINP, VDR genotypes, and interactions between VDR and ERá genotypes could be useful to predict a decrease in BMD in Argentine postmenopausal women.

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Authors and Affiliations

  1. Laboratorio de Metabolismo Fosfocálcico y Vitamina D “Dr. Fernando Cañas,” Cátedra de Bioquímica y Biología Molecular, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Cosquín 1673, Barrio Jardín, 5014, Córdoba, Argentina

    Adriana Pérez, Beatriz García, María Lavezzo, Eliana Elías, Miriam Binci, Viviana Centeno, Arturo Alisio & Nori Tolosa de Talamoni

  2. Centro Privado de Endocrinología, Osteología y Metabolismo, Córdoba, Argentina

    María Ulla & María Rivoira

Authors
  1. Adriana Pérez
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  2. María Ulla
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  3. Beatriz García
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  4. María Lavezzo
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  10. Nori Tolosa de Talamoni
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Correspondence to Nori Tolosa de Talamoni.

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Pérez, A., Ulla, M., García, B. et al. Genotypes and clinical aspects associated with bone mineral density in Argentine postmenopausal women. J Bone Miner Metab 26, 358–365 (2008). https://doi.org/10.1007/s00774-007-0840-2

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  • DOI: https://doi.org/10.1007/s00774-007-0840-2

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