Contribution to the certification of cadmium and lead amount content in the BCR CRM-278R mussel tissue by isotope dilution mass spectrometry

Abstract

 Metrological certification through a primary method of measurement and how it can be achieved is demonstrated in this paper, using the example of re-certification of cadmium and lead content in a biological material, the Bureau Communataire de Reference, reference material CRM-278R mussel tissue. The measurement method used was isotope dilution in combination with inductively coupled plasma mass spectrometry. Microwave digestion was applied to the samples prior to the measurements. A detailed uncertainty budget was evaluated according to the International Organisation of Standardisation, Guide to the Expression of Uncertainty and EURACHEM Guide, resulting in an expanded uncertainty.