Skip to main content

Advertisement

Log in

Human amniotic fluid stem cells: a new perspective

  • Minireview Article
  • Published:
Amino Acids Aims and scope Submit manuscript

Summary.

The discovery of amniotic fluid stem cells initiated a new and very promising field in stem cell research. In the last four years amniotic fluid stem cells have been shown to express markers specific to pluripotent stem cells, such as Oct-4. Due to their high proliferation potential, amniotic fluid stem cell lineages can be established. Meanwhile, they have been shown to harbor the potential to differentiate into cells of all three embryonic germ layers. It will be a major aim for the future to define the potential of this new source of stem cells for therapies related to specific diseases.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • P Bossolasco T Montemurro L Cova S Zangrossi C Calzarossa S Miatiotis D Soligo S Bosari V Silani GL Deliliers P Rebulla L Lazzari (2006) ArticleTitleMolecular and phenotypic characterization of human amniotic fluid cells and their differentiation potential Cell Res 16 329–336 Occurrence Handle16617328 Occurrence Handle10.1038/sj.cr.7310043 Occurrence Handle1:CAS:528:DC%2BD28XjsV2gtL0%3D

    Article  PubMed  CAS  Google Scholar 

  • P De Coppi G Bartsch MM Siddiqui T Xu TX Santos L Perin G Mostoslavsky AC Serre EY Snyder JJ Yoo ME Furth S Soker A Atala (2007) ArticleTitleIsolation of amniotic stem cell lines with potential for therapy Nat Biotechnol 25 100–106 Occurrence Handle17206138 Occurrence Handle10.1038/nbt1274 Occurrence Handle1:CAS:528:DC%2BD2sXis1Grtw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • PS in t’Anker SA Scherjon C Kleijburg-van der Keur WA Noort FHJ Claas R Willemze WE Fibbe HHH Kanhai (2003) ArticleTitleAmniotic fluid as a novel source of mesenchymal stem cells for therapeutic transplantation Blood 102 1548–1549 Occurrence Handle10.1182/blood-2003-04-1291 Occurrence Handle1:CAS:528:DC%2BD3sXmsFWktbo%3D

    Article  CAS  Google Scholar 

  • KR Karlmark A Freilinger E Marton M Rosner G Lubec M Hengstschläger (2005) ArticleTitleActivation of Oct-4 and Rex-1 promoters in human amniotic fluid cells Int J Mol Med 16 987–992 Occurrence Handle16273276 Occurrence Handle1:CAS:528:DC%2BD2MXhtlWrt77F

    PubMed  CAS  Google Scholar 

  • A Kaviani TE Perry A Dzakovic RW Jennings MM Ziegler DO Fauza (2001) ArticleTitleThe amniotic fluid as a source of cells for fetal tissue engineering J Pediatr Surg 36 1662–1665 Occurrence Handle11685697 Occurrence Handle10.1053/jpsu.2001.27945 Occurrence Handle1:STN:280:DC%2BD3MnhtVCrtg%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • M Pesce HR Schöler (2001) ArticleTitleOct-4: gatekeeper in the beginning of mammalian development Stem Cells 19 271–278 Occurrence Handle11463946 Occurrence Handle10.1634/stemcells.19-4-271 Occurrence Handle1:CAS:528:DC%2BD3MXlvFKktL4%3D

    Article  PubMed  CAS  Google Scholar 

  • A Prusa M Hengstschläger (2002) ArticleTitleAmniotic fluid cells and human stem cell research – a new connection Med Sci Monit 8 253–257

    Google Scholar 

  • AR Prusa E Marton M Rosner G Bernaschek M Hengstschläger (2003) ArticleTitleOct-4 expressing cells in human amniotic fluid: a new source for stem cell research? Hum Reprod 18 1489–1493 Occurrence Handle12832377 Occurrence Handle10.1093/humrep/deg279

    Article  PubMed  Google Scholar 

  • AR Prusa E Marton M Rosner D Bettelheim G Lubec A Pollak G Bernaschek M Hengstschläger (2004) ArticleTitleNeurogenic cells in human amniotic fluid Am J Obstet Gynecol 191 309–314 Occurrence Handle15295384 Occurrence Handle10.1016/j.ajog.2003.12.014

    Article  PubMed  Google Scholar 

  • M-S Tsai J-L Lee Y-J Chang S-M Hwang (2004) ArticleTitleIsolation of human multipotent mesenchymal stem cells from second-trimester amniotic fluid using a novel two-stage culture protocol Hum Reprod 19 1450–1456 Occurrence Handle15105397 Occurrence Handle10.1093/humrep/deh279

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Additional information

Authors’ address: Prof. M. Hengstschläger, Medical Genetics, Obstetrics and Gynecology, Medical University of Vienna, Währinger Gürtel 18–20, 1090 Vienna, Austria

Rights and permissions

Reprints and permissions

About this article

Cite this article

Siegel, N., Rosner, M., Hanneder, M. et al. Human amniotic fluid stem cells: a new perspective. Amino Acids 35, 291–293 (2008). https://doi.org/10.1007/s00726-007-0593-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00726-007-0593-1

Navigation