Summary.
In this proof-of-concept study, we attempt to determine whether the cause-mutation relationship defined by randomness is protein dependent by predicting mutations in H5N1 neuraminidases from influenza A virus, because we have recently conducted several concept-initiated studies on the prediction of mutations in hemagglutinins from influenza A virus. In our concept-initiated studies, we defined the randomness as a cause for mutation, upon which we built a cause-mutation relationship, which is then switched into the classification problem because the occurrence and non-occurrence of mutations can be classified as unity and zero. Thereafter, we used the logistic regression and neural network to solve this classification problem to predict the mutation positions in hemagglutinins, and then used the amino acid mutating probability to predict the would-be-mutated amino acids. As the previous results were promising, we extend this approach to other proteins, such as H5N1 neuraminidase in this study, and further address various issues raised during the development of this approach. The result of this study confirms that we can use this cause-mutation relationship to predict the mutations in H5N1 neuraminidases.
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G Wu S Yan (2007c) ArticleTitleImprovement of prediction of mutation positions in H5N1 hemagglutinins of influenza A virus using neural network with distinguishing of arginine, leucine and serine Protein Pept Lett 14 465–470 Occurrence Handle1:CAS:528:DC%2BD2sXntlyqs7g%3D
Wu G, Yan S (2007d) Prediction of mutations initiated by internal power in H3N2 hemagglutinins of influenza A virus from North America. Int J Pept Res Ther (http://dx.doi.org/10.1007/s10989-007-9104-1)
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Authors’ address: Guang Wu, Computational Mutation Project, DreamSciTech Consulting 301, Building 12, Nanyou A-zone, Jiannan Road, Shenzhen, Guangdong Province CN-518054, China
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Wu, G., Yan, S. Prediction of mutations engineered by randomness in H5N1 neuraminidases from influenza A virus. Amino Acids 34, 81–90 (2008). https://doi.org/10.1007/s00726-007-0579-z
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DOI: https://doi.org/10.1007/s00726-007-0579-z