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Cytoplasmic/nuclear localization of tuberin in different cell lines

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Summary.

Tuberous sclerosis (TSC) is an autosomal dominantly inherited disease affecting 1 in 6000 individuals. The TSC gene products, hamartin and tuberin, form a complex, of which tuberin is assumed to be the functional component being involved in a wide variety of different cellular processes. Tuberin has been demonstrated to be localized to both, the cytoplasm and the nucleus. The cytoplasmic/nuclear localization of tuberin is known to be regulated by the serine/threonine protein kinase Akt. Akt also regulates the cytoplasmic/nuclear localization of the cyclin-dependent kinase inhibitor p27. In this study the localization of these two Akt-regulated proteins was analysed in different cell lines.

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  1. Medical Genetics, Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria

    M. Rosner & M. Hengstschläger

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  1. M. Rosner
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  2. M. Hengstschläger
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Rosner, M., Hengstschläger, M. Cytoplasmic/nuclear localization of tuberin in different cell lines. Amino Acids 33, 575–579 (2007). https://doi.org/10.1007/s00726-007-0541-0

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