Skip to main content

Advertisement

SpringerLink
Log in

Protein-polyamine conjugation by transglutaminase in cancer cell differentiation: Review article

  • Published:
Amino Acids Aims and scope Submit manuscript

Summary.

Considerable and intense progress has been made in the understanding of the chemistry, molecular biology and cell biology of transglutaminases (TGases: EC 2.3.2.13). The knowledge that very different processes such as cell growth, reproduction and death are dependent on the presence of adequate levels of these enzymes and that the amount of both free and protein-conjugated polyamines, formed by the enzyme, are capable of modulating the differentiation and proliferative capability of several cell types, has prompted a multitude of researchers to study the role of these fascinating molecules in cancer cell differentiation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Author information

Authors and Affiliations

  1. Department of Biology, University “Tor Vergata”, Rome, Italy

    A. Lentini & S. Beninati

  2. Department of Biochemistry and Biophysics, II University of Naples “Federico II”, Naples, Italy

    A. Abbruzzese, M. Caraglia & M. Marra

Authors
  1. A. Lentini
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. Abbruzzese
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. Caraglia
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. Marra
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. S. Beninati
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lentini, A., Abbruzzese, A., Caraglia, M. et al. Protein-polyamine conjugation by transglutaminase in cancer cell differentiation: Review article. Amino Acids 26, 331–337 (2004). https://doi.org/10.1007/s00726-004-0079-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00726-004-0079-3

Search

Navigation