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Design, synthesis, and antimicrobial evaluation of novel 2-arylbenzothiazole analogs bearing fluorine and piperazine moieties

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Abstract

The synthesis of a novel series of 5-fluoro-6-(4-methylpiperazin-1-yl)-substituted phenylbenzo[d]thiazoles is reported. These molecules have been screened against different bacteria and fungi strains. Among these, two compounds show excellent bacterial growth inhibition against Gram-positive bacteria Staphylococcus aureus with MIC 32 μg/cm3 compared to tamoxifen used as a positive standard.

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Acknowledgements

Antimicrobial screening was performed by CO-ADD (The Community for Antimicrobial Drug Discovery) Australia, funded by the Wellcome Trust (UK) and The University of Queensland (Australia). Financial support from Sultan Qaboos University, Oman, is gratefully acknowledged. R. A.-J. and R. S. would like to thank the Research School PLUS at Ruhr University of Bochum for awarding a visiting international fellowship to R. A.-J.

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Authors and Affiliations

  1. Chemistry Department, College of Science, Sultan Qaboos University, Muscat, Oman

    Thuraya Al-Harthy, Wajdi M. Zoghaib & Raid Abdel-Jalil

  2. Biomolecular NMR, Ruhr University of Bochum, 44780, Bochum, Germany

    Raphael Stoll

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  1. Thuraya Al-Harthy
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  2. Wajdi M. Zoghaib
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  3. Raphael Stoll
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  4. Raid Abdel-Jalil
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Correspondence to Raid Abdel-Jalil.

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Al-Harthy, T., Zoghaib, W.M., Stoll, R. et al. Design, synthesis, and antimicrobial evaluation of novel 2-arylbenzothiazole analogs bearing fluorine and piperazine moieties. Monatsh Chem 149, 645–651 (2018). https://doi.org/10.1007/s00706-017-2088-4

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  • DOI: https://doi.org/10.1007/s00706-017-2088-4

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