Abstract
A novel class of medicinally important 4-aryl-substituted dihydropyrimidine derivatives fused to pyrazole and triazole scaffolds has been found which is obtained via a newly designed regioselective domino reaction using tungstate sulfuric acid (TSA) as a Brønsted acid recyclable catalyst. Throughout this tri-component tandem reaction, 4-aryl-substituted dihydropyrimidine derivatives fused to pyrazole and triazole moieties were regioselectively formed under environmentally benign solvent-free conditions with high yields. By this achievement, some novel potentially interesting biologically active products were synthesized via a green and eco-friendly procedure.
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The authors would like to gratefully thank Yasouj University Research Council for partial support of this work.
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Farahi, M., Karami, B., Banaki, Z. et al. TSA-catalyzed regioselective synthesis of medicinally important 4-aryl-substituted dihydropyrimidine derivatives fused to pyrazole and triazole scaffolds via an efficient and green Domino reaction. Monatsh Chem 148, 1469–1475 (2017). https://doi.org/10.1007/s00706-017-1932-x
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DOI: https://doi.org/10.1007/s00706-017-1932-x