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Efficient synthesis of novel chromenopyrido[3,2-e]isothiazolo[2,3-a]pyrimidines via a non-catalytic one-pot three-component reaction

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Abstract

Herein, a novel series of chromenopyrido[3,2-e]isothiazolo[2,3-a]pyrimidines were synthesized by a three-component reaction of 4-hydroxy coumarin, aromatic aldehydes, and 5-amino-2,3-dihydro-7H-thiazolo[3,2-a]pyrimidin-7-one under catalyst-free conditions in PEG 400 as a green solvent. The optimal reaction condition of this reaction was determined. The obtained product’s structure was elucidated via NMR, IR, mass spectra, and elemental analysis techniques. This protocol has various advantages: excellent yields, short reaction times, no column chromatography, and green reaction media.

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Acknowledgements

The Research Council of the Ferdowsi University of Mashhad is acknowledged for the financial support (Grant No. 3/50328).

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  1. Department of Chemistry, Faculty of Science, Ferdowsi University of Mashhad, P.O.Box 9177948974, Mashhad, Iran

    Maryam Danehchin & Abbas Ali Esmaeili

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  1. Maryam Danehchin
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  2. Abbas Ali Esmaeili
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Correspondence to Abbas Ali Esmaeili.

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Danehchin, M., Esmaeili, A.A. Efficient synthesis of novel chromenopyrido[3,2-e]isothiazolo[2,3-a]pyrimidines via a non-catalytic one-pot three-component reaction. Res Chem Intermed 48, 629–646 (2022). https://doi.org/10.1007/s11164-021-04613-5

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