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Facile synthesis of 2-(2-arylpyrrolidin-1-yl)pyrimidines via acid-catalyzed reaction of N-(4,4-diethoxybutyl)pyrimidin-2-amine with phenols

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Abstract

N-(4,4-diethoxybutyl)pyrimidin-2-amine undergoes acid-catalyzed intramolecular cyclisation in the presence of phenols leading to the formation of 2-(2-arylpyrrolidin-1-yl)pyrimidine derivatives. Target compounds were obtained with moderate to good yields by operationally simple one-step procedure.

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Acknowledgments

This work was supported by the Russian Scientific Foundation (Grant No. 14-50-00014).

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Authors and Affiliations

  1. A.E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences, Kazan, Russia

    Almir S. Gazizov, Natalya I. Kharitonova, Andrey V. Smolobochkin, Viktor V. Syakaev, Alexander R. Burilov & Michail A. Pudovik

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  1. Almir S. Gazizov
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  2. Natalya I. Kharitonova
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  3. Andrey V. Smolobochkin
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  4. Viktor V. Syakaev
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  5. Alexander R. Burilov
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  6. Michail A. Pudovik
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Corresponding author

Correspondence to Almir S. Gazizov.

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Gazizov, A.S., Kharitonova, N.I., Smolobochkin, A.V. et al. Facile synthesis of 2-(2-arylpyrrolidin-1-yl)pyrimidines via acid-catalyzed reaction of N-(4,4-diethoxybutyl)pyrimidin-2-amine with phenols. Monatsh Chem 146, 1845–1849 (2015). https://doi.org/10.1007/s00706-015-1545-1

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  • DOI: https://doi.org/10.1007/s00706-015-1545-1

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