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Synthesis of antiprotozoal diamines by regioselective insertion of nitrogen into a bicyclic ring system

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Abstract

The regioselective insertion of nitrogen in a bicyclic octanone skeleton is reported. The structure was established by a single crystal structure analysis. The antiprotozoal activities of lactames and their reduction products were determined and discussed.

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Authors and Affiliations

  1. Institute of Pharmaceutical Sciences, Karl-Franzens-University, Graz, Austria

    Noor-ul-Amin Mohsin, Werner Seebacher, Johanna Faist & Robert Weis

  2. Institute for Chemistry and Technology of Materials (ICTM), University of Technology, Graz, Austria

    Robert Saf

  3. Institute of Chemistry, Karl-Franzens-University, Graz, Austria

    Ferdinand Belaj

  4. Swiss Tropical and Public Health Institute, Basel, Switzerland

    Marcel Kaiser & Reto Brun

Authors
  1. Noor-ul-Amin Mohsin
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  2. Werner Seebacher
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  3. Johanna Faist
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  4. Ferdinand Belaj
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  5. Robert Saf
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  6. Marcel Kaiser
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  7. Reto Brun
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  8. Robert Weis
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Corresponding author

Correspondence to Werner Seebacher.

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Mohsin, NuA., Seebacher, W., Faist, J. et al. Synthesis of antiprotozoal diamines by regioselective insertion of nitrogen into a bicyclic ring system. Monatsh Chem 145, 1319–1327 (2014). https://doi.org/10.1007/s00706-014-1243-4

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  • DOI: https://doi.org/10.1007/s00706-014-1243-4

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