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Microwave-assisted synthesis and antimicrobial activity of 5-trihalomethyl-3-arylisoxazoles

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Abstract

A series of twelve 5-trihalomethyl-3-arylisoxazoles was synthesized and screened for antibacterial and antifungal activities. The compounds were synthesized from the cyclondensation of 1,1,1-trihalo-4-alkoxy-3-alken-2-ones [CX 3C(O)C(R 2)=C(R 1)OR, where X = Cl and F; R=Me; R 2=H; R 1=H, Me, F, Cl, Br, and NO2] with hydroxylamine hydrochloride through a rapid one-pot reaction via microwave irradiation. Some of the 5-trihalomethyl-3-arylisoxazoles exhibited good in vitro anti-Cryptococcus activity.

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Authors and Affiliations

  1. Núcleo de Química de Heterociclos (NUQUIMHE), Centro de Ciências Naturais e Exatas, Departamento de Química, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil

    Marcos A. P. Martins, Pablo Machado, Luciana A. Piovesan, Alex F. C. Flores, Carolina Scheidt, Helio G. Bonacorso & Nilo Zanatta

  2. Centro de Ciências da Saúde, Departamento de Análises Clínicas e Toxicológicas, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil

    Marli M. A. de Campos

Authors
  1. Marcos A. P. Martins
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  2. Pablo Machado
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  3. Luciana A. Piovesan
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  4. Alex F. C. Flores
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  5. Marli M. A. de Campos
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  6. Carolina Scheidt
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  7. Helio G. Bonacorso
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  8. Nilo Zanatta
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Corresponding author

Correspondence to Marcos A. P. Martins.

Additional information

Correspondence: Marcos A. P. Martins, Núcleo de Química de Heterociclos (NUQUIMHE), Centro de Ciências Naturais e Exatas, Departamento de Química, Universidade Federal de Santa Maria, 97.105-900 Santa Maria, RS, Brazil.

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Martins, M., Machado, P., Piovesan, L. et al. Microwave-assisted synthesis and antimicrobial activity of 5-trihalomethyl-3-arylisoxazoles. Monatsh Chem 139, 985–990 (2008). https://doi.org/10.1007/s00706-007-0849-1

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  • DOI: https://doi.org/10.1007/s00706-007-0849-1

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