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Microwave-Assisted Synthesis and Antimicrobial Activity of Novel Pyrazole–Indanone Hybrid Analogs

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Abstract

A simple and efficient microwave-assisted protocol has been developed for the synthetic of a series of novel pyrazole–indanone hybrid analogs. The target compounds have been synthesized by the Claisen–Schmidt condensation of different 1,3-diphenyl-1H-pyrazole-4-carbaldehydes with 2,3-dihydro-1H-inden-1-one in the presence of potassium hydroxide. The compounds were characterized by IR, 1H and 13C NMR, and mass spectra and were found to exhibit potent antimicrobial activity in vitro.

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ACKNOWLEDGMENTS

The authors are thankful to the Head, Department of Chemistry for providing laboratory facilities. The authors are also thankful to the Director, Central Facilities for Research and Development (CFRD), Osmania University, for providing IR and NMR spectral analysis.

Funding

Financial assistance from DRS-SAP program to carry out this work is highly appreciated.

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Authors and Affiliations

  1. Department of Chemistry, University College of Science, Osmania University, 500007, Hyderabad, India

    N. Venkatesh, Sh. Sundergoud, M. Kumara Swamy & P. Veerasomaiah

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  1. N. Venkatesh
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  2. Sh. Sundergoud
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  3. M. Kumara Swamy
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  4. P. Veerasomaiah
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Correspondence to P. Veerasomaiah.

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Venkatesh, N., Sundergoud, S., Swamy, M.K. et al. Microwave-Assisted Synthesis and Antimicrobial Activity of Novel Pyrazole–Indanone Hybrid Analogs. Russ J Org Chem 56, 1635–1639 (2020). https://doi.org/10.1134/S1070428020090213

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