Carnitine Palmitoyltransferase-I and Regulation of Mitochondrial Fatty Acid Oxidation

Summary.

Carnitine palmitoyltransferase-I catalyzes the regulated step in overall mitochondrial fatty acid oxidation. The enzyme is controlled by the steady state level of malonyl-CoA and the enzyme’s sensitivity to inhibition by malonyl-CoA. The former is established by the activities of acetyl-CoA carboxylase 2 and malonyl-CoA decarboxylase, while the latter is influenced by post-translational modification (phosphorylation) of CPT-I and/or by changes in the lipid environment of CPT-I.