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Detection of vaccine-like strains of lumpy skin disease virus in outbreaks in Russia in 2017

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Abstract

Lumpy skin disease (LSD) has affected many regions of Russia since its first occurrence in 2015. The most devastating year for Russia was 2016, when the virus resurged following a modified stamping-out campaign, causing 313 outbreaks in 16 regions. To avoid unwanted adverse reactions following the use of live attenuated vaccines against LSD virus (LSDV), sheeppox-based vaccines were administered during vaccination campaigns. As a result, LSD was successfully contained in all Russian regions in 2017. In the same year, however, LSD emerged anew in a few regions of the Privolzhsky Federal District of Russia along the northern border of Kazakhstan, which then necessitated vaccinating cattle with a live attenuated LSDV vaccine. Although live attenuated LSDV vaccines are prohibited in Russia, several vaccine-like LSDV strains were identified in the 2017 outbreaks, including commercial farms and backyard animals exhibiting clinical signs consistent with those of field LSDV strains. Sequence alignments of three vaccine-like LSDV strains showed clear similarity to the corresponding RPO30 and GPCR gene sequences of commercial attenuated viruses. How vaccine-like strains spread into Russian cattle remains to be clarified.

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Authors and Affiliations

  1. Federal Center for Animal Health, Vladimir, Russia

    Aleksandr Kononov, Olga Byadovskaya, Svetlana Kononova, Roman Yashin, Nikolay Zinyakov, Vladimir Mischenko, Nataliya Perevozchikova & Alexander Sprygin

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  1. Aleksandr Kononov
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  2. Olga Byadovskaya
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  3. Svetlana Kononova
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  4. Roman Yashin
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  8. Alexander Sprygin
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Correspondence to Alexander Sprygin.

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Handling Editor: William G. Dundon.

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Kononov, A., Byadovskaya, O., Kononova, S. et al. Detection of vaccine-like strains of lumpy skin disease virus in outbreaks in Russia in 2017. Arch Virol 164, 1575–1585 (2019). https://doi.org/10.1007/s00705-019-04229-6

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