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Characterization of a novel highly pathogenic H5N2 avian influenza virus isolated from a duck in eastern China

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Abstract

During surveillance for avian influenza viruses (AIVs) in live-poultry markets (LPMs) in eastern China in 2013, one H5N2 AIV was isolated from a duck. Phylogenetic analysis showed that the hemagglutinin of this strain belongs to clade 2.3.4 and received its genes from H5, H3 and H6 AIVs of poultry in China. The virulence of this strain was examined in chickens and mice, and it was found to be highly pathogenic in chickens but demonstrated moderate pathogenicity in mice. These results suggest that active surveillance of AIVs in LPMs should be used in an early warning system for avian influenza outbreaks.

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Acknowledgements

This study was supported by grants from the National Key Technologies R&D Programme for the 12th Five-Year Plan of China (2012ZX1000-004-005) and the State Key Laboratory of Independent Task (No. 2014ZZ12).

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Authors and Affiliations

  1. State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou, 310003, Zhejiang, China

    Haibo Wu, Xiaorong Peng, Changzhong Jin, Linfang Cheng, Xiangyun Lu, Tiansheng Xie, Hangping Yao & Nanping Wu

  2. Animal Husbandry and Veterinary Institute, Zhejiang Academy of Agricultural Science, Hangzhou, 310021, China

    Lihua Xu

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  1. Haibo Wu
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  2. Xiaorong Peng
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  3. Lihua Xu
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  4. Changzhong Jin
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  5. Linfang Cheng
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  7. Tiansheng Xie
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  8. Hangping Yao
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  9. Nanping Wu
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Correspondence to Nanping Wu.

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Wu, H., Peng, X., Xu, L. et al. Characterization of a novel highly pathogenic H5N2 avian influenza virus isolated from a duck in eastern China. Arch Virol 159, 3377–3383 (2014). https://doi.org/10.1007/s00705-014-2193-1

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  • DOI: https://doi.org/10.1007/s00705-014-2193-1

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