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Association between Sirtuin 2 gene rs10410544 polymorphism and depression in Alzheimer’s disease in two independent European samples

  • Neurology and Preclinical Neurological Studies - Original Article
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Abstract

Among the several genes associated with late-onset Alzheimer’s disease (LOAD), recently, Sirtuin genes have roused a growing interest because of their involvement in metabolic homeostasis and in brain aging. Particularly SIRT2 gene has been associated with Alzheimer’s disease (AD) as well as with mood disorders. The aim of this study is to investigate the possible associations between Sirtuin 2 gene (SIRT2) rs10410544 polymorphism and AD as well as depression in AD. In addition, we performed some exploratory analyses to investigate possible associations between the rs10410544 genotype and clinical features. We investigated these associations in two independent samples: the first one was composed of 275 Greek inhabitants and 117 patients; the second sample counted 181 Italian people and 43 patients. All patients were affected by LOAD. We failed to find any association between rs10410544 genotype and AD in the two samples. On the other hand, we found an association between the single nucleotide polymorphism (SNP) and depressive symptomatology (in the total sample p = 0.002), which was modulated by the tumor necrosis factor (TNF) values. Particularly, TT genotype seems to be protective versus depression. Finally, in the exploratory analyses, we found that the TT genotype was associated with earlier AD onset and a longer duration of the illness. In conclusion, we confirmed the association between SIRT2 gene and mood disturbances, although in AD patients. Further, we provided evidence that the TT genotype may be protective versus depressive symptoms, allowing an easier and thus earlier diagnosis of AD. This awareness may lead to a more detailed approach to these patients concerning diagnosis and therapy.

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Acknowledgments

The research at Istituto di Ricerche Famacologiche “Mario Negri” was supported by Fondazione Italo Monzino, Milan, Italy.

Conflict of interest

No conflict of interest is present for the authors.

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Authors and Affiliations

  1. Department of Biomedical and NeuroMotor Sciences, University of Bologna, Viale Carlo Pepoli 5, 40123, Bologna, Italy

    Stefano Porcelli, Raffaele Salfi, Anna Rita Atti, Siegfried Alberti, Martina Balestri, Agnese Marsano, Virginia Bernabei, Barbara Ferrari, Loredana Lia, Diana De Ronchi & Alessandro Serretti

  2. Department of Psychiatry, University of Athens Medical School, Eginition Hospital, Athens, Greece

    Antonis Politis, Ioannis Liappas, Evangelia Stamouli, Antonis Mailis & George N. Papadimitriou

  3. Department of Neuroscience, Istituto di Ricerche Farmacologiche “Mario Negri”, Milan, Italy

    Diego Albani, Armando Chierchia, Gloria Biella & Gianluigi Forloni

  4. Laboratory of Pharmacology, University of Athens Medical School, Athens, Greece

    Aikaterini Zisaki

  5. Laboratory of Biological Chemistry, University of Athens Medical School, Athens, Greece

    Christina Piperi

  6. Golgi Cenci Foundation, Abbiategrasso, Milan, Italy

    Letizia Polito

Authors
  1. Stefano Porcelli
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  2. Raffaele Salfi
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  3. Antonis Politis
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  5. Diego Albani
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  8. Aikaterini Zisaki
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  11. Siegfried Alberti
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  16. Gloria Biella
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  18. Virginia Bernabei
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  19. Barbara Ferrari
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Correspondence to Alessandro Serretti.

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Porcelli, S., Salfi, R., Politis, A. et al. Association between Sirtuin 2 gene rs10410544 polymorphism and depression in Alzheimer’s disease in two independent European samples. J Neural Transm 120, 1709–1715 (2013). https://doi.org/10.1007/s00702-013-1045-6

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  • DOI: https://doi.org/10.1007/s00702-013-1045-6

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