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New aspects of the molecular constituents of tissue barriers

  • Basic Neurosciences, Genetics and Immunology - Review Article
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Abstract

Epithelial and endothelial tissue barriers are based on tight intercellular contacts (Tight Junctions, TJs) between neighbouring cells. TJs are multimeric complexes, located at the most apical border of the lateral membrane. So far, a plethora of proteins locating at tight intercellular contacts have been discovered, the role of which has just partly been unraveled. Yet, there is convincing evidence that many TJ proteins exert a dual role: They act as structural components at the junctional site and they are involved in signalling pathways leading to alterations of gene expression and cell behaviour (migration, proliferation). This review will shortly summarize the classical functions of TJs and TJ-related proteins and will introduce a new category, termed the “non-classical” functions of junctional proteins. A particular focus will be directed towards the nuclear targeting of junctional proteins and the downstream effects elicited by their intranuclear activities.

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Acknowledgments

This work was supported by the Austrian FWF P-18743 and by research grants from the Paracelsus Medical Private University (PMU) Salzburg, Austria. Bauer HC and Bauer H are participants of the NEUROBID consortium (EU 7th FP).

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Authors and Affiliations

  1. Department of Organismic Biology, University of Salzburg, Hellbrunner Strasse 34, 5020, Salzburg, Austria

    H. C. Bauer, J. Zweimueller-Mayer, C. Lehner & H. Bauer

  2. Baxter Innovations GmbH, 2304, Orth an der Donau, Austria

    A. Traweger

  3. Paracelsus Private Medical University, Müllner Hauptstrasse 48, 5020, Salzburg, Austria

    H. C. Bauer & H. Tempfer

  4. Department of Traumatology and Sports Injuries, Paracelsus Private Medical University, Müllner Hauptstrasse 48, 5020, Salzburg, Austria

    C. Lehner

  5. Biological Research Center, Institute of Biophysics, Temesvari krt 62, 6726, Szeged, Hungary

    I. Krizbai & I. Wilhelm

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  1. H. C. Bauer
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Bauer, H.C., Traweger, A., Zweimueller-Mayer, J. et al. New aspects of the molecular constituents of tissue barriers. J Neural Transm 118, 7–21 (2011). https://doi.org/10.1007/s00702-010-0484-6

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