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Proanthocyanidin-rich fraction from Croton celtidifolius Baill confers neuroprotection in the intranasal 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine rat model of Parkinson’s disease

  • Basic Neurosciences, Genetics and Immunology - Original Article
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Abstract

We have recently demonstrated that rodents treated intranasally with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) suffered impairments in olfactory, cognitive and motor functions associated with time-dependent disruption of dopaminergic neurotransmission in different brain structures conceivably analogous to those observed during different stages of Parkinson’s disease (PD). On the other hand, the proanthocyanidin-rich fraction (PRF) obtained from the bark of Croton celtidifolius Baill (Euphorbiaceae), a tree frequently found in the Atlantic forest in south Brazil, has been described to have several neurobiological activities including antioxidant and anti-inflammatory properties, which may be of interest in the treatment of PD. The present data indicated that the pretreatment with PRF (10 mg/kg, i.p.) during five consecutive days was able to prevent mitochondrial complex-I inhibition in the striatum and olfactory bulb, as well as a decrease of the enzyme tyrosine hydroxylase expression in the olfactory bulb and substantia nigra of rats infused with a single intranasal administration of MPTP (1 mg/nostril). Moreover, pretreatment with PRF was found to attenuate the short-term social memory deficits, depressive-like behavior and reduction of locomotor activity observed at different periods after intranasal MPTP administration in rats. Altogether, the present findings provide strong evidence that PRF from C. celtidifolius may represent a promising therapeutic tool in PD, thus being able to prevent both motor and non-motor early symptoms of PD, together with its neuroprotective potential.

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Acknowledgments

This study was supported by grants from the Brazilian institutions Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) and the Fundação de Apoio à Pesquisa do Estado de Santa Catarina (FAPESC). The authors have no financial or personal conflicts of interest related to this study.

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  1. Departamento de Farmacologia, Universidade Federal de Santa Catarina, Florianópolis, SC, 88049-900, Brazil

    Eduardo L. G. Moreira, Daniel Rial, Aderbal S. Aguiar Jr, Jarbas M. Siqueira, Silvia DalBó, Rosa M. Ribeiro-do-Valle & Rui D. S. Prediger

  2. Centro de Neurociências Aplicadas (CeNAp), Hospital Universitário, Universidade Federal de Santa Catarina, Florianópolis, SC, 88040-900, Brazil

    Eduardo L. G. Moreira, Cláudia P. Figueiredo & Rui D. S. Prediger

  3. Departamento de Química, Universidade Federal de Santa Catarina, Florianópolis, SC, 88040-900, Brazil

    Heros Horst & Moacir G. Pizzolatti

  4. Departamento de Bioquímica, Universidade Federal de Santa Catarina, Florianópolis, SC, 88040-900, Brazil

    Jade de Oliveira, Gianni Mancini, Andreza F. De Bem & Alexandra Latini

  5. Departamento de Ciências Fisiológicas, Universidade Federal de Santa Catarina, Florianópolis, SC, 88040-900, Brazil

    Tiago S. dos Santos & José Marino-Neto

  6. Departamento de Química, Universidade Federal de Santa Maria, Santa Maria, RS, 97105-900, Brazil

    Jardel G. Villarinho, Francielle V. Pinheiro & Juliano Ferreira

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  1. Eduardo L. G. Moreira
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Moreira, E.L.G., Rial, D., Aguiar, A.S. et al. Proanthocyanidin-rich fraction from Croton celtidifolius Baill confers neuroprotection in the intranasal 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine rat model of Parkinson’s disease. J Neural Transm 117, 1337–1351 (2010). https://doi.org/10.1007/s00702-010-0464-x

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