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[123I]-FP-CIT SPECT and olfaction test in patients with combined postural and rest tremor

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Summary.

Mixed-type tremors pose a clinical diagnostic challenge. The aim of the study was to better characterize patients with combined postural and rest tremor. Patients were categorized into four groups: essential tremor (ET) (n = 7), combined rest + postural tremor (n = 17), PD (n = 17), and control subjects (n = 9). All underwent the University of Pennsylvania Smell Identification Test (UPSIT). The mixed-tremor group was also evaluated with SPECT imaging using the dopamine transporter (DaT) ligand 123I-labeled FP-CIT. There was no significant difference in olfaction scores between the mixed tremor and essential tremor groups (23.2 ± 6.6 vs 21.7 ± 4.9) or between these groups and controls (27.2 ± 5.0). The patients with PD had significantly lower scores than all the other groups (13.7 ± 5.4, p < 0.001). Of the 12 patients with mixed tremor evaluated by SPECT, 9 had normal findings. This study suggests that rest tremor is part of the spectrum of ET, even in patients with long-standing disease. However, in a minority of patients, there might be transformation of ET–PD.

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Authors and Affiliations

  1. Rabin Medical Center, Department of Neurology, Beilinson Campus, Petah Tiqwa, Israel

    R. Djaldetti, T. A. Treves & E. Melamed

  2. Rabin Medical Center, Department of Otolaryngology, Beilinson Campus, Petah Tiqwa, Israel

    B. I. Nageris & E. Yaniv

  3. Edith Wolfson Medical Center, Department of Nuclear Medicine, Holon and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

    M. Lorberboym

Authors
  1. R. Djaldetti
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  2. B. I. Nageris
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  3. M. Lorberboym
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  4. T. A. Treves
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  5. E. Melamed
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  6. E. Yaniv
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Corresponding author

Correspondence to R. Djaldetti.

Additional information

Correspondence: Ruth Djaldetti, Rabin Medical Center, Department of Neurology, Beilinson Campus, Petah Tiqwa 49100, Israel

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Djaldetti, R., Nageris, B., Lorberboym, M. et al. [123I]-FP-CIT SPECT and olfaction test in patients with combined postural and rest tremor. J Neural Transm 115, 469–472 (2008). https://doi.org/10.1007/s00702-007-0851-0

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  • DOI: https://doi.org/10.1007/s00702-007-0851-0

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