Summary
Microdialysis technique was used to study the effects of the locally applied alpha adrenoceptor agonist phenylephrine and antagonist phentolamine on the basal noradrenaline efflux as well as on the noradrenaline uptake inhibitor desipramine-elicited noradrenaline efflux in the nucleus accumbens (NAc) of freely moving rats.
Tetrodotoxin reduced basal noradrenaline efflux by 72%, whereas desipramine increased it by 204%. Phenylephrine reduced the basal noradrenaline efflux by 32% and phentolamine blocked this effect. Phentolamine elevated the basal noradrenaline efflux by 150% and phenylephrine counteracted this effect. The desipramine-elicited noradrenaline efflux was not affected by phenylephrine, but enhanced by phentolamine. Desipramine counteracted the effects of phenylephrine and potentiated those of phentolamine.
These results indicate that the accumbal noradrenaline efflux is under inhibitory control of alpha adrenoceptors that are suggested to be presynaptically located on adrenergic nerve terminals in the NAc. Furthermore, this study suggests that the conformational state of alpha adrenoceptors varies across the available amount of noradrenaline. The clinical impact of these data is discussed.
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References
H Benveniste AJ Hansen NS Ottosen (1989) ArticleTitleDetermination of brain interstitial concentrations by microdialysis J Neurochem 52 1741–1750 10.1111/j.1471-4159.1989.tb07252.x Occurrence Handle10.1111/j.1471-4159.1989.tb07252.x Occurrence Handle1:CAS:528:DyaL1MXksFeltbk%3D Occurrence Handle2723633
JK Buitelaar D Michelson M Danckaerts C Gillberg TJ Spencer A Zuddas DE Faries S Zang (2007) ArticleTitleA randomized, double-blind study of contimuation treatment for attention-deficit/hyperactivity disorder after 1 year Biol Psychiatry 61 694–699 10.1016/j.biopsych.2006.03.066 Occurrence Handle10.1016/j.biopsych.2006.03.066 Occurrence Handle1:CAS:528:DC%2BD2sXhvVymsr8%3D Occurrence Handle16893523
JM Cedarbaum GK Aghajanian (1978) ArticleTitleAfferent projections to the rat locus coeruleus as determined by a retrograde tracing technique J Comp Neurol 178 1–16 10.1002/cne.901780102 Occurrence Handle10.1002/cne.901780102 Occurrence Handle1:STN:280:DyaE1c7jtVegtA%3D%3D Occurrence Handle632368
AR Cools B Ellenbroek R van den Bos M Gelissen (1987) ArticleTitleMesolimbic noradrenaline: specificity, stability and dose-dependency of individual-specific responses to mesolimbic injections of alpha-noradrenergic agonists Behav Brain Res 25 49–61 10.1016/0166-4328(87)90044-1 Occurrence Handle10.1016/0166-4328(87)90044-1 Occurrence Handle1:CAS:528:DyaL2sXmt12ktbw%3D Occurrence Handle3620086
AR Cools R van den Bos G Ploeger BA Ellenbroek (1991) Gating function of noradrenaline in the ventral striatum: its role in behavioural responses to environmental and pharmacological challenges P Willner J Scheel-Krüger (Eds) The mesolimbic dopamine system: from motivation to action J Wiley Chichester 141–173
JM Delfs Y Zhu JP Druhan GS Aston-Jones (1998) ArticleTitleOrigin of noradrenergic afferents to the shell subregion of the nucleus accumbens: anterograde and retrograde tract-tracing studies in the rat Brain Res 806 127–140 10.1016/S0006-8993(98)00672-6 Occurrence Handle10.1016/S0006-8993(98)00672-6 Occurrence Handle1:CAS:528:DyaK1cXlsl2nsrY%3D Occurrence Handle9739125
G Di Chiara G Tanda E Carboni (1996) ArticleTitleEstimation of in-vivo neurotransmitter release by brain microdialysis: the issue of validity Behav Pharmacol 7 640–657 10.1097/00008877-199611000-00009 Occurrence Handle1:CAS:528:DyaK2sXitleju7k%3D Occurrence Handle11224460
G Di Chiara V Bassareo S Fenu MA De Luca L Spina C Cadoni E Acqas E Carboni V Valentini D Lecca (2004) ArticleTitleDopamine and drug addiction: the nucleus accumbens shell connection Neuropharmacology 47 IssueIDSuppl 1 227–241 10.1016/j.neuropharm.2004.06.032 Occurrence Handle10.1016/j.neuropharm.2004.06.032 Occurrence Handle1:CAS:528:DC%2BD2cXotF2ht70%3D Occurrence Handle15464140
K Fusa T Saigusa N Koshikawa AR Cools (2002) ArticleTitleTyrosine-induced release of dopamine is under inhibitory control of presynaptic dopamine D2 and, probably, D3 receptors in the dorsal striatum, but not in the nucleus accumbens Eur J Pharmacol 448 143–150 10.1016/S0014-2999(02)01911-8 Occurrence Handle10.1016/S0014-2999(02)01911-8 Occurrence Handle1:CAS:528:DC%2BD38Xls1Wrs7c%3D Occurrence Handle12144934
K Fusa I Takahashi S Watanabe Y Aono H Ikeda T Saigusa H Nagase T Suzuki N Koshikawa AR Cools (2005) ArticleTitleThe non-peptidic delta opioid receptor agonist TAN-67 enhances dopamine efflux in the nucleus accumbens of freely moving rats via a mechanism that involves both glutamate and free radicals Neuroscience 130 743–753 10.1016/j.neuroscience.2004.10.016 Occurrence Handle10.1016/j.neuroscience.2004.10.016 Occurrence Handle1:CAS:528:DC%2BD2cXhtVKlsbfI
AA Gershon T Vishne L Grunhaus (2007) ArticleTitleDopamine D2-like receptors and the antidepressant response Biol Psychiatry 61 145–153 10.1016/j.biopsych.2006.05.031 Occurrence Handle10.1016/j.biopsych.2006.05.031 Occurrence Handle1:CAS:528:DC%2BD2sXmtVGgtA%3D%3D Occurrence Handle16934770
AA Grace (2000) ArticleTitleGating of information flow within the limbic system and the pathophysiology of schizophrenia Brain Res Rev 31 330–341 10.1016/S0165-0173(99)00049-1 Occurrence Handle10.1016/S0165-0173(99)00049-1 Occurrence Handle1:STN:280:DC%2BD3c7osFGjtQ%3D%3D Occurrence Handle10719160
I Gustafson EJ Westerberg T Wieloch (1991) ArticleTitleExtracellular brain cortical levels of noradrenaline in ischemia: effects of desipramine and postischemic administration of idazoxan Exp Brain Res 86 555–561 10.1007/BF00230528 Occurrence Handle10.1007/BF00230528 Occurrence Handle1:CAS:528:DyaK3MXmslWhu78%3D Occurrence Handle1684752
L Heimer (2003) ArticleTitleA new anatomical framework for neuropsychiatric disorders and drug abuse Am J Psychiatry 160 1726–1739 10.1176/appi.ajp.160.10.1726 Occurrence Handle10.1176/appi.ajp.160.10.1726 Occurrence Handle14514480
L Hetey B Zimmermann (1986) ArticleTitleCharacterization of the synaptosomal high-affinity uptake of noradrenaline in the nucleus accumbens of rats Biomed Biochim Acta 45 1203–1207 Occurrence Handle1:CAS:528:DyaL28XlvVClu78%3D Occurrence Handle3814110
H Ikeda S Moribe M Sato A Kotani N Koshikawa AR Cools (2007) ArticleTitleAdrenergic receptors in the nucleus accumbens shell differentially modulate dopamine and acetylcholine receptor-mediated turning behaviour Eur J Pharmacol 554 175–182 10.1016/j.ejphar.2006.10.007 Occurrence Handle10.1016/j.ejphar.2006.10.007 Occurrence Handle1:CAS:528:DC%2BD28Xht12mtr7M Occurrence Handle17113067
LS Jones LL Gauger JN Davis (1985) ArticleTitleAnatomy of brain alpha1-adrenergic receptors: in vitro autoradiography with [125I]-heat J Comp Neurol 231 190–208 10.1002/cne.902310207 Occurrence Handle10.1002/cne.902310207 Occurrence Handle1:CAS:528:DyaL2MXhsVelt78%3D Occurrence Handle2981906
T Kienast A Heinz (2006) ArticleTitleDopamine and the diseased brain CNS Neurol Disord Drug Targets 5 109–131 Occurrence Handle10.2174/187152706784111560 Occurrence Handle1:CAS:528:DC%2BD28XisFKns7c%3D Occurrence Handle16613557
F Levy (2004) ArticleTitleSynaptic gating and ADHD: a biological theory of comorbidity of ADHD and anxiety Neuropsychopharmacology 29 1589–1596 10.1038/sj.npp.1300469 Occurrence Handle10.1038/sj.npp.1300469 Occurrence Handle1:CAS:528:DC%2BD2cXmvVOqsLo%3D Occurrence Handle15114344
MY Li QS Yan LL Coffey ME Reith (1996) ArticleTitleExtracellular dopamine, norepinephrine, and serotonin in the nucleus accumbens of freely moving rats during intracerebral dialysis with cocaine and other monoamine uptake blockers J Neurochem 66 559–568 Occurrence Handle1:CAS:528:DyaK28XnsFCltw%3D%3D Occurrence Handle8592125 Occurrence Handle10.1046/j.1471-4159.1996.66020559.x
N Lindefors G Amberg U Ungerstedt (1989) ArticleTitleIntracerebral microdialysis: I. Experimental studies of diffusion kinetics J Pharmacol Methods 22 141–156 10.1016/0160-5402(89)90011-9 Occurrence Handle10.1016/0160-5402(89)90011-9 Occurrence Handle1:CAS:528:DyaK3cXjtVOhsw%3D%3D Occurrence Handle2586111
EJ Nestler WA Carlezon SuffixJr (2006) ArticleTitleThe mesolimbic dopamine reward circuit in depression Biol Psychiatry 59 1151–1159 10.1016/j.biopsych.2005.09.018 Occurrence Handle10.1016/j.biopsych.2005.09.018 Occurrence Handle1:CAS:528:DC%2BD28XmtVOitrk%3D Occurrence Handle16566899
B Nurse VA Russell JJ Taljaard (1984) ArticleTitleα2 and β-adrenoceptor agonists modulate [3H]dopamine release from rat nucleus accumbens slices: implications for research into depression Neurochem Res 9 1231–1238 10.1007/BF00973036 Occurrence Handle10.1007/BF00973036 Occurrence Handle1:CAS:528:DyaL2cXmt1ehu7o%3D Occurrence Handle6095129
RD Oades GM Halliday (1987) ArticleTitleVentral tegmental (A10) system: neurobiology. 1. Anatomy and connectivity Brain Res 434 117–165 Occurrence Handle1:STN:280:DyaL2s3hsFajsw%3D%3D Occurrence Handle3107759
H Okutsu S Watanabe I Takahashi Y Aono T Saigusa N Koshikawa AR Cools (2006) ArticleTitleEndomorphin-2 and endomorphin-1 promote the extracellular amount of accumbal dopamine via nonopioid and mu-opioid receptors, respectively Neuropsychopharmacology 31 375–383 10.1038/sj.npp.1300804 Occurrence Handle10.1038/sj.npp.1300804 Occurrence Handle1:CAS:528:DC%2BD28XkvFynuw%3D%3D Occurrence Handle16034447
CW Olanow JA Obeso F Stocchi (2006) ArticleTitleContinuous dopamine-receptor treatment of Parkinson’s disease: rationale and clinical implications Lancet Neurol 5 677–687 10.1016/S1474-4422(06)70521-X Occurrence Handle10.1016/S1474-4422(06)70521-X Occurrence Handle1:CAS:528:DC%2BD28XosVamu70%3D Occurrence Handle16857573
L Pani (2002) ArticleTitleClinical implications of dopamine research in schizophrenia Curr Med Res Opin 18 IssueIDSuppl 3 s3–s7 10.1185/030079902125001056 Occurrence Handle10.1185/030079902125001056 Occurrence Handle12418605
G Paxinos C Watson (1998) The rat brain in stereotaxic coordinates EditionNumber2 Academic Press New York
TC Rainbow A Biegon (1983) ArticleTitleQuantitative autoradiography of [3H]prazosin binding sites in rat forebrain Neurosci Lett 40 221–226 10.1016/0304-3940(83)90042-3 Occurrence Handle10.1016/0304-3940(83)90042-3 Occurrence Handle1:CAS:528:DyaL3sXlvVynu70%3D Occurrence Handle6316208
T Reisine (1981) ArticleTitleAdaptive changes in catecholamine receptors in the central nervous system Neuroscience 6 1471–1502 10.1016/0306-4522(81)90221-9 Occurrence Handle10.1016/0306-4522(81)90221-9 Occurrence Handle1:CAS:528:DyaL3MXlt1Gks7k%3D Occurrence Handle6115335
ME Reith MY Li QS Yan (1997) ArticleTitleExtracellular dopamine, norepinephrine, and serotonin in the ventral tegmental area and nucleus accumbens of freely moving rats during intracerebral dialysis following systemic administration of cocaine and other uptake blockers Psychopharmacology (Berl) 134 309–317 10.1007/s002130050454 Occurrence Handle10.1007/s002130050454 Occurrence Handle1:CAS:528:DyaK2sXnvFWiu74%3D
T Saigusa K Takada SC Baker R Kumar JD Stephenson (1997) ArticleTitleDopamine efflux in the rat nucleus accumbens evoked by dopamine receptor stimulation in the entorhinal cortex is modulated by oestradiol and progesterone Synapse 25 37–43 10.1002/(SICI)1098-2396(199701)25:1<37::AID-SYN5>3.0.CO;2-G Occurrence Handle10.1002/(SICI)1098-2396(199701)25:1<37::AID-SYN5>3.0.CO;2-G Occurrence Handle1:CAS:528:DyaK2sXhtlChtA%3D%3D Occurrence Handle8987146
T Saigusa T Tuinstra N Koshikawa AR Cools (1999) ArticleTitleHigh and low responders to novelty: effects of a catecholamine synthesis inhibitor on novelty-induced changes in behavior and release of accumbal dopamine Neuroscience 88 1153–1163 10.1016/S0306-4522(98)00275-9 Occurrence Handle10.1016/S0306-4522(98)00275-9 Occurrence Handle1:CAS:528:DyaK1MXis1Wr Occurrence Handle10336126
T Saigusa K Fusa H Okutsu N Koshikawa (2001) ArticleTitleMonitoring of extracellular dopamine levels in the dorsal striatum and the nucleus accumbens with 5-minute on-line microdialysis in freely moving rats J Oral Sci 43 129–134 Occurrence Handle1:CAS:528:DC%2BD3MXmvF2rt7k%3D Occurrence Handle11515597
JD Salmone M Correa SM Mingote SM Weber (2005) ArticleTitleBeyond the reward hypothesis: alternative function of nucleus accumbens dopamine Curr Opin Pharmacol 5 34–41 10.1016/j.coph.2004.09.004 Occurrence Handle10.1016/j.coph.2004.09.004 Occurrence Handle1:CAS:528:DC%2BD2MXms1Cmtg%3D%3D
AN Schoffelmeer LJ Vanderschuren DE van Royen G Wardeh F Hogenboom AH Mulder (1998) ArticleTitleLack of alpha2-adrenoceptor autoregulation of noradrenaline release in rat nucleus accumbens slices Naunyn Schmiedebergs Arch Pharmacol 357 87–90 10.1007/PL00005142 Occurrence Handle10.1007/PL00005142 Occurrence Handle1:CAS:528:DyaK1cXmsVWhuw%3D%3D Occurrence Handle9459577
EJS Sounga-Barke (2005) ArticleTitleCausal models of attention-deficit/hyperactivity disorder: from common simple deficits to multiple developmental pathways Biol Psychiatry 57 1231–1238 10.1016/j.biopsych.2004.09.008 Occurrence Handle10.1016/j.biopsych.2004.09.008
K yuTakada T Murai T Kanayama N Koshikawa (1993) ArticleTitleEffects of midazolam and flunitrazepam on the release of dopamine from rat striatum measured by in vivo microdialysis Br J Anaesthesiol 70 181–185 10.1093/bja/70.2.181 Occurrence Handle10.1093/bja/70.2.181
K Tomiyama M Noguchi N Koshikawa M Kobayashi (1993) ArticleTitleYM-09151-2 but not l-sulpiride induces transient dopamine release in rat striatum via a tetrodotoxin-insensitive mechanism J Neurochem 60 1690–1695 10.1111/j.1471-4159.1993.tb13392.x Occurrence Handle10.1111/j.1471-4159.1993.tb13392.x Occurrence Handle1:CAS:528:DyaK3sXkt1SgurY%3D Occurrence Handle8473891
K Tomiyama N Koshikawa K Funada K Oka M Kobayashi (1995) ArticleTitleIn vivo microdialysis evidence for transient dopamine release by benzazepines in rat striatum J Neurochem 65 2790–2795 Occurrence Handle1:CAS:528:DyaK2MXpsFert78%3D Occurrence Handle7595579 Occurrence Handle10.1046/j.1471-4159.1995.65062790.x
T Tuinstra AR Cools (2000a) ArticleTitleNewly synthesized dopamine in the nucleus accumbens is regulated by beta-adrenergic, but not alpha-adrenergic, receptors Neuroscience 98 743–747 10.1016/S0306-4522(00)00175-5 Occurrence Handle10.1016/S0306-4522(00)00175-5 Occurrence Handle1:CAS:528:DC%2BD3cXks12ntrg%3D
T Tuinstra AR Cools (2000b) ArticleTitleHigh and low responders to novelty: effects of adrenergic agents on the regulation of accumbal dopamine under challenged and non-challenged conditions Neuroscience 99 55–64 10.1016/S0306-4522(00)00139-1 Occurrence Handle10.1016/S0306-4522(00)00139-1 Occurrence Handle1:CAS:528:DC%2BD3cXlt1Kis7o%3D
T Tuinstra P Cobelens L Lubbers M Verheij AR Cools (2002) ArticleTitleHigh and low responders to novelty and mesolimbic noradrenaline: effects of noradrenergic agents on radial-maze performance Behav Neurosci 116 1084–1092 10.1037/0735-7044.116.6.1084 Occurrence Handle10.1037/0735-7044.116.6.1084 Occurrence Handle1:CAS:528:DC%2BD38Xpslegt7Y%3D Occurrence Handle12492307
J Zhou (2004) ArticleTitleNorepinephrine transporter inhibitors and their therapeutic potential Drugs Future 29 1235–1244 10.1358/dof.2004.029.12.855246 Occurrence Handle10.1358/dof.2004.029.12.855246 Occurrence Handle1:CAS:528:DC%2BD2MXhvFGjsrw%3D Occurrence Handle16871320
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Aono, Y., Saigusa, T., Watanabe, S. et al. Role of alpha adrenoceptors in the nucleus accumbens in the control of accumbal noradrenaline efflux: a microdialysis study with freely moving rats. J Neural Transm 114, 1135–1142 (2007). https://doi.org/10.1007/s00702-007-0745-1
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DOI: https://doi.org/10.1007/s00702-007-0745-1