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Interaction between TPH1 and GNB3 genotypes and electroconvulsive therapy in major depression

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Summary

We studied the association between tryptophan hydroxylase 1 (TPH1) A218C and G-protein beta-3 subunit (GNB3) C825T polymorphisms and treatment response in electroconvulsive therapy (ECT). The sample consisted of 119 patients with major depressive disorder (MDD) and 398 controls. Neither TPH1 nor GNB3 polymorphisms are associated with treatment response. However, subjects carrying TPH1 CC genotype are more likely to belong to the patient sample than to the controls. In female subjects, T-allele of GNB3 polymorphism increases the risk of being a treatment-resistant patient with MDD. Moreover, in females the combination of TPH1 CC and GNB3 CT + TT genotype is associated with an increased risk of belonging to the patient group.

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Authors and Affiliations

  1. Medical School, University of Tampere, Tampere, Finland

    S. Anttila, K. Huuhka, M. Huuhka, R. Rontu, K. M. Mattila, E. Leinonen & T. Lehtimäki

  2. Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Centre for Laboratory Medicine, Tampere University Hospital, Tampere, Finland

    S. Anttila, R. Rontu, K. M. Mattila & T. Lehtimäki

  3. Department of Psychiatry, Tampere University Hospital, Pitkäniemi, Finland

    K. Huuhka, M. Huuhka & E. Leinonen

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  1. S. Anttila
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Anttila, S., Huuhka, K., Huuhka, M. et al. Interaction between TPH1 and GNB3 genotypes and electroconvulsive therapy in major depression. J Neural Transm 114, 461–468 (2007). https://doi.org/10.1007/s00702-006-0583-6

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