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Association study of C825T polymorphism of the G-protein b3 subunit gene with schizophrenia and mood disorders

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Summary.

Alterations of G proteins have been implicated in major psychiatric illnesses. A C825T polymorphism of a gene encoding the β3 subunit of heterotrimeric G proteins (GNB3) was reported to be associated with several pathological conditions, such as hypertension and depressive disorder. We examined whether this polymorphism is associated with functional psychoses in a Japanese sample of 370 schizophrenics, 164 bipolars, 68 depressive patients, and 198 controls. We obtained no evidence for an association of the polymorphism with any diagnostic group.

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Authors and Affiliations

  1. Department of Psychiatry and Genome Research Center, Teikyo University School of Medicine, Tokyo,, , , , , , JP

    H. Kunugi & S. Nanko

  2. Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Saitama,, , , , , , JP

    T. Kato

  3. Department of Neuropsychiatry, Faculty of Medicine, University of Tokyo, Tokyo,, , , , , , JP

    R. Fukuda

  4. Department of Psychiatry, Showa University Fujigaoka Hospital, Yokohama, and, , , , , , JP

    M. Tatsumi

  5. Saitama Comprehensive Mental Health Center, Saitama, Japan, , , , , , JP

    T. Sakai

Authors
  1. H. Kunugi
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  2. T. Kato
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  3. R. Fukuda
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  4. M. Tatsumi
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  5. T. Sakai
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  6. S. Nanko
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Additional information

Received July 16, 2001; accepted November 7, 2001

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Kunugi, H., Kato, T., Fukuda, R. et al. Association study of C825T polymorphism of the G-protein b3 subunit gene with schizophrenia and mood disorders. J Neural Transm 109, 213–218 (2002). https://doi.org/10.1007/s007020200018

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  • DOI: https://doi.org/10.1007/s007020200018

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