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The GNB3 C825T polymorphism and depression among subjects with alcohol dependence

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Summary

The T allele of the C825T polymorphism in the G-protein β3 subunit gene (GNB3) is related to the increase of signal transduction by the G-protein. G-proteins are intermediary paths in signal transduction from receptors involved in mood regulation and substance dependence. We studied the C825T polymorphism in individuals with (i) alcohol and nicotine dependence (n = 109), (ii) nicotine dependence only (n = 117) and (iii) non-dependent controls (n = 108). We also tested for possible associations with psychiatric comorbidities among alcohol-dependent individuals. No differences were detected for allele and genotype frequencies in individuals with or without dependencies. Alcohol-dependent individuals with the heterozygous genotype presented more frequently major depressive disorder (χ2 = 12.34; p = 0.002). These findings, taken together with other studies suggesting an influence of the C825T polymorphism in major depressive disorder, support the hypothesis of the involvement of G-proteins in mood regulation.

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  1. Department of Genetics, Institute of Biosciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil

    A. P. Prestes, F. Z. C. Marques, M. H. Hutz & C. H. D. Bau

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  1. A. P. Prestes
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  2. F. Z. C. Marques
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  3. M. H. Hutz
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  4. C. H. D. Bau
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Prestes, A., Marques, F., Hutz, M. et al. The GNB3 C825T polymorphism and depression among subjects with alcohol dependence. J Neural Transm 114, 469–472 (2007). https://doi.org/10.1007/s00702-006-0550-2

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  • DOI: https://doi.org/10.1007/s00702-006-0550-2

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