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Malignant orbital schwannoma with massive intracranial recurrence

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Abstract

Background

A 62 year old male presented with progressive diplopia, left orbital pain and impairment of visual acuity.

Method and Findings

Neuroradiological investigation disclosed an orbital tumour. The lesion was totally excised. Histopathology examination revealed a malignant peripheral nerve sheath tumour (MPNST). The tumour recurred with intracranial extension. The patient died 13 months after the initial diagnosis.

Conclusions

To our knowledge, this is the first reported example of a massive intracranial recurrence of an orbital MPNST. The epidemiological features, clinical course and treatment of these lesions are discussed.

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Author information

Authors and Affiliations

  1. Department of Neurosurgery, Ioannina University Hospital, Ioannina, Greece

    George Miliaras & Konstantinos Polyzoidis

  2. Department of Neurosurgery, Hippokratio General Hospital, Aristotle University, Thessaloniki, Greece

    Parmenion P. Tsitsopoulos

  3. Department of Ophthalmology, Ioannina University Hospital, Ioannina, Greece

    Ioannis Asproudis

  4. Department of Radiation Therapy, Ioannina University Hospital, Ioannina, Greece

    Periklis Tsekeris

  5. Department of Neurosurgery, AHEPA University Hospital, St. Kyriakidis 1, 54636, Thessaloniki, Greece

    Konstantinos Polyzoidis

Authors
  1. George Miliaras
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  2. Parmenion P. Tsitsopoulos
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  3. Ioannis Asproudis
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  4. Periklis Tsekeris
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  5. Konstantinos Polyzoidis
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Corresponding author

Correspondence to Konstantinos Polyzoidis.

Additional information

Comment

This is a well presented and clearly written case report of an unusual and aggressive malignant peripheral nerve sheath tumour (MPNST) of the orbit that spread intracranially after resection.

R Weller

University of Southampton

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Miliaras, G., Tsitsopoulos, P.P., Asproudis, I. et al. Malignant orbital schwannoma with massive intracranial recurrence. Acta Neurochir (Wien) 150, 1291–1294 (2008). https://doi.org/10.1007/s00701-008-0159-3

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  • DOI: https://doi.org/10.1007/s00701-008-0159-3

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