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Inhibitory effect of vasopressin receptor antagonist OPC-31260 on experimental brain oedema induced by global cerebral ischaemia

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Summary

The effects of the non-peptide vasopressin V2 receptor antagonist 5-dimethylamino-1-[4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-benzazepine hydrochloride (OPC-31260) on the cerebral oedema induced by general cerebral hypoxia were studied in rats. The general cerebral hypoxia was produced by bilateral common carotid ligation in Sprague-Dawley rats of the CFY strain. By 6 h after the ligation, half of the rats had died, but the survival rate was significantly higher following OPC-31260 administration. Electron microscopic examinations revealed typical ischaemic changes after the carotid ligation. The carotid ligation increased the brain contents of water and Na+ and enhanced the plasma vasopressin level. The increased brain water and Na+ accumulation was prevented by OPC-31260 administration, but the plasma vasopressin level was further enhanced by OPC-31260. These results demonstrate the important role of vasopressin in the development of the disturbances in brain water and electrolyte balance in response to general cerebral hypoxia. The carotid ligation-induced cerebral oedema was significantly reduced following oral OPC-31260 administration. The protective mechanism exerted by OPC-31260 stems from its influence on the renal vasopressin V2 receptors. These observations might suggest an effective approach to the treatment of global hypoxia-induced cerebral oedema in humans.

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References

  • M Burnier AF Fricker D Hayoz J Nussberger HR Brunner (1999) ArticleTitlePharmacokinetic and pharmacodynamic effects of YM087, a combined V1/V2 vasopressin receptor antagonist in normal subjects Eur J Clin Pharmacol 55 633–637 Occurrence Handle10638391 Occurrence Handle10.1007/s002280050685 Occurrence Handle1:CAS:528:DyaK1MXntl2qs7g%3D

    Article  PubMed  CAS  Google Scholar 

  • G Decaux (2001) ArticleTitleDifference in solute excretion during correction of hyponatremic patients with cirrhosis or syndrome of inappropriate secretion of antidiuretic hormone by oral vasopressin V2 receptor antagonist VPA-985 J Lab Clin Med 138 18–21 Occurrence Handle11433224 Occurrence Handle10.1067/mlc.2001.116025 Occurrence Handle1:CAS:528:DC%2BD3MXlsFShur8%3D

    Article  PubMed  CAS  Google Scholar 

  • J Dogterom TB van Wimersma Greidanus D De Wied (1978) ArticleTitleVasopressin in cerebrospinal fluid and plasma of man, dog, and rat Am J Physiol 234 E463–E467 Occurrence Handle645897 Occurrence Handle1:CAS:528:DyaE1cXkt1Wjsr4%3D

    PubMed  CAS  Google Scholar 

  • B Ekstrom-Jodal J Elfverson C von Essen (1979) ArticleTitleCerebral blood flow, cerebrovascular resistance, cerebral metabolic rate of oxygen and intracranial pressure during and after severe prolonged arterial hypoxia in dogs. The role of dopamine in the deep hypoxic state Acta Neurol Scand 60 36–49 Occurrence Handle495041 Occurrence Handle1:STN:280:DyaL3c%2FjvVOhtw%3D%3D Occurrence Handle10.1111/j.1600-0404.1979.tb02949.x

    Article  PubMed  CAS  Google Scholar 

  • MR Emerson SR Nelson FE Samson TL Pazdernik (1999) ArticleTitleA global hypoxia preconditioning model: neuroprotection against seizure-induced specific gravity changes (edema) and brain damage in rats Brain Res Brain Res Protoc 4 360–366 Occurrence Handle10592346 Occurrence Handle10.1016/S1385-299X(99)00041-0 Occurrence Handle1:STN:280:DC%2BD3c%2FotFSmsw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • LM Fleeman PJ Irwin PA Phillips J West (2000) ArticleTitleEffects of an oral vasopressin receptor antagonist (OPC-31260) in a dog with syndrome of inappropriate secretion of antidiuretic hormone Aust Vet J 78 825–830 Occurrence Handle11194468 Occurrence Handle10.1111/j.1751-0813.2000.tb10497.x Occurrence Handle1:CAS:528:DC%2BD3MXhsVKjug%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • G Fujisawa S Ishikawa Y Tsuboi K Okada T Saito (1993) ArticleTitleTherapeutic efficacy of non-peptide ADH antagonist OPC-31260 in SIADH rats Kidney Int 44 19–23 Occurrence Handle8355461 Occurrence Handle10.1038/ki.1993.207 Occurrence Handle1:CAS:528:DyaK3sXmsVWjurY%3D

    Article  PubMed  CAS  Google Scholar 

  • N Fujita SE Ishikawa S Sasaki G Fujisawa K Fushimi F Marumo T Saito (1995) ArticleTitleRole of water channel AQP-CD in water retention in SIADH and cirrhotic rats Am J Physiol 269 F926–F931 Occurrence Handle8594889 Occurrence Handle1:CAS:528:DyaK28Xkt1alsQ%3D%3D

    PubMed  CAS  Google Scholar 

  • P Gross C Palm (2000) ArticleTitleThe treatment of hyponatraemia using vasopressin antagonists Exp Physiol 85 253S–257S Occurrence Handle10795929 Occurrence Handle10.1111/j.1469-445X.2000.tb00030.x Occurrence Handle1:CAS:528:DC%2BD3cXjtVOhsr8%3D

    Article  PubMed  CAS  Google Scholar 

  • Grove L, Christiensen P, Bie P (1995) Effects of receptor blockade on the natriuretic action of vasopressin. 1st Joint World Congress of Neurohypophysis and Vasopressin, Nasu, Tochigi, Japan, p 139 (Abstract)

  • D Guyader A Patat EJ Ellis-Grosse GP Orczyk (2002) ArticleTitlePharmacodynamic effects of a nonpeptide antidiuretic hormone V2 antagonist in cirrhotic patients with ascites Hepatology 36 1197–1205 Occurrence Handle12395330 Occurrence Handle10.1053/jhep.2002.36375 Occurrence Handle1:CAS:528:DC%2BD38XovFaksbc%3D

    Article  PubMed  CAS  Google Scholar 

  • WM Hunter FC Greenwood (1962) ArticleTitlePreparation of iodine-131 labelled human growth hormone of high specific activity Nature 194 495–496 Occurrence Handle14450081 Occurrence Handle10.1038/194495a0 Occurrence Handle1:STN:280:DyaF38%2FltFCrsw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • T Imaizumi S Harada Y Hirooka H Masaki M Momohara A Takeshita (1992) ArticleTitleEffects of OPC-21268, an orally effective vasopressin V1 receptor antagonist in humans Hypertension 20 54–58 Occurrence Handle1319959 Occurrence Handle1:CAS:528:DyaK38XkvVeitLo%3D

    PubMed  CAS  Google Scholar 

  • T Inoue A Ohnishi A Matsuo B Kawai M Harada K Okada Y Yamamura T Tanaka (1996) ArticleTitleAquaretic effect of a potent, orally active, nonpeptide V2 antagonist in cirrhosis Hepatology 23 T26

    Google Scholar 

  • S Ishikawa K Okada T Saito (1992) ArticleTitleEffect of new non-peptide arginine vasopressin (AVP) antagonists OPC-31260 and OPC-21268 on cellular action of AVP in cultured rat renal papillary collecting tubule cells J Am Soc Nephrol 3 794

    Google Scholar 

  • W Jimenez CS Gal J Ros C Cano P Cejudo M Morales-Ruiz V Arroyo M Pascal F Rivera JP Maffrand J Rodes (2000) ArticleTitleLong-term aquaretic efficacy of a selective nonpeptide V(2)-vasopressin receptor antagonist, SR121463, in cirrhotic rats J Pharmacol Exp Ther 295 83–90 Occurrence Handle10991964

    PubMed  Google Scholar 

  • I Jojart F Laczi FA Laszlo K Boda S Csati T Janaky (1987) ArticleTitleHyponatremia and increased secretion of vasopressin induced by vincristine administration in rat Exp Clin Endocrinol 90 213–220 Occurrence Handle3428363 Occurrence Handle1:CAS:528:DyaL2sXmt1yltrw%3D Occurrence Handle10.1055/s-0029-1210692

    Article  PubMed  CAS  Google Scholar 

  • M Koltai I Lepran G Nemecz L Szekeres (1983) ArticleTitleThe possible mechanism of protection induced by dexamethasone against sudden death due to coronary ligation in conscious rats Br J Pharmacol 79 327–329 Occurrence Handle6689132 Occurrence Handle1:CAS:528:DyaL3sXkvVaksb4%3D

    PubMed  CAS  Google Scholar 

  • M Koltai A Tosaki G Adam F Joo G Nemecz L Szekeres (1984) ArticleTitlePrevention by macrocortin of global cerebral ischemia in Sprague-Dawley rats Eur J Pharmacol 105 347–350 Occurrence Handle6548971 Occurrence Handle10.1016/0014-2999(84)90630-7 Occurrence Handle1:CAS:528:DyaL2cXmt1aqt7Y%3D

    Article  PubMed  CAS  Google Scholar 

  • F Laczi M Fekete D de Wied (1983) ArticleTitleAntidiuretic activity and immunoreactive arginin-vasopressin levels in eye plexus blood during passive avoidance behavior in rats Life Sci 32 577–589 Occurrence Handle6835024 Occurrence Handle10.1016/0024-3205(83)90202-3 Occurrence Handle1:CAS:528:DyaL3sXht1Sgs7w%3D

    Article  PubMed  CAS  Google Scholar 

  • F Laczi T Janaky T Ivanyi J Julesz FA Laszlo (1987) ArticleTitleOsmoregulation of arginine-8-vasopressin secretion in primary hypothyroidism and in Addison’s disease Acta Endocrinol (Copenh) 114 389–395 Occurrence Handle1:STN:280:DyaL2s7otVGksg%3D%3D

    CAS  Google Scholar 

  • FA Laszlo S Csati L Balaspiri (1984) ArticleTitlePrevention of hyponatraemia and cerebral oedema by the vasopressin antagonist d/CH2/5Tyr/Et/VAVP in rats treated with pitressin tannate Acta Endocrinol (Copenh) 106 56–60 Occurrence Handle1:CAS:528:DyaL2cXitVCjsLk%3D

    CAS  Google Scholar 

  • FA Laszlo C Varga L Balaspiri (1993) ArticleTitlePrevention of cerebral edema by the vasopressin antagonist d(CH2)5D-Ile2Ile4Ala9AVP in rats with experimental subarachnoid haemorrhage Ann NY Acad Sci 689 627–629 Occurrence Handle8373062 Occurrence Handle10.1111/j.1749-6632.1993.tb55611.x Occurrence Handle1:CAS:528:DyaK3sXmsVWlsrg%3D

    Article  PubMed  CAS  Google Scholar 

  • FA Laszlo C Varga T Doczi (1995a) ArticleTitleCerebral oedema after subarachnoid haemorrhage. Pathogenetic significance of vasopressin Acta Neurochir (Wien) 133 122–133 Occurrence Handle10.1007/BF01420062 Occurrence Handle1:STN:280:DyaK28zlt1Oluw%3D%3D

    Article  CAS  Google Scholar 

  • FA Laszlo C Varga T Doczi (1995b) ArticleTitleImpaired water metabolism and cerebral oedema following experimental subarachnoid haemorrhage in rats Eur J Neurol 2 199–204

    Google Scholar 

  • FA Laszlo C Varga S Nakamura (1999) ArticleTitleVasopressin receptor antagonist OPC-31260 prevents cerebral oedema after subarachnoid haemorrhage Eur J Pharmacol 364 115–122 Occurrence Handle9932713 Occurrence Handle10.1016/S0014-2999(98)00836-X Occurrence Handle1:CAS:528:DyaK1MXosFWktg%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • AH Molnar C Varga T Janaky G Toth J Farkas F Laszlo FA Laszlo (2007) ArticleTitleBiological half-life and organ distribution of [(3)H]8-arginine vasopressin following administration of vasopressin receptor antagonist OPC-31260 Regul Pept 141 12–18 Occurrence Handle17258819 Occurrence Handle10.1016/j.regpep.2006.12.011 Occurrence Handle1:CAS:528:DC%2BD2sXjs1Kqsrs%3D

    Article  PubMed  CAS  Google Scholar 

  • A Ohnishi Y Orita R Okahara H Fujihara T Inoue Y Yamamura Y Yabuuchi T Tanaka (1993) ArticleTitlePotent aquaretic agent. A novel nonpeptide selective vasopressin 2 antagonist (OPC-31260) in men J Clin Invest 92 2653–2659 Occurrence Handle8254021 Occurrence Handle10.1172/JCI116881 Occurrence Handle1:CAS:528:DyaK2cXpsFWksw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • A Ohnishi Y Orita N Takagi T Fujita T Toyoki Y Ihara Y Yamamura T Inoue T Tanaka (1995) ArticleTitleAquaretic effect of a potent, orally active, nonpeptide V2 antagonist in men J Pharmacol Exp Ther 272 546–551 Occurrence Handle7853167 Occurrence Handle1:CAS:528:DyaK2MXjs1OhsL0%3D

    PubMed  CAS  Google Scholar 

  • H Okada H Suzuki Y Kanno Y Yamamura T Saruta (1994) ArticleTitleEffects of vasopressin V1 and V2 receptor antagonists on progressive renal failure in rats Clin Sci (Lond) 86 399–404 Occurrence Handle1:CAS:528:DyaK2cXlt1CrtL4%3D

    CAS  Google Scholar 

  • W Pohle C Rauca (1994) ArticleTitleHypoxia protects against the neurotoxicity of kainic acid Brain Res 644 297–304 Occurrence Handle8050040 Occurrence Handle10.1016/0006-8993(94)91693-4 Occurrence Handle1:CAS:528:DyaK2cXivFGrur4%3D

    Article  PubMed  CAS  Google Scholar 

  • J Risvanis M Naitoh CI Johnston LM Burrell (1999) ArticleTitleIn vivo and in vitro characterisation of a nonpeptide vasopressin V(1A) and V(2) receptor antagonist (YM087) in the rat Eur J Pharmacol 381 23–30 Occurrence Handle10528130 Occurrence Handle10.1016/S0014-2999(99)00530-0 Occurrence Handle1:CAS:528:DyaK1MXmvVKitbw%3D

    Article  PubMed  CAS  Google Scholar 

  • AG Robinson MD Fitzsimmons (1993) ArticleTitleVasopressin homeostasis: coordination of synthesis, storage and release Regul Pept 45 225–230 Occurrence Handle8511347 Occurrence Handle10.1016/0167-0115(93)90210-Y Occurrence Handle1:CAS:528:DyaK3sXksVWju7w%3D

    Article  PubMed  CAS  Google Scholar 

  • C Serradeil-Le Gal (1998) ArticleTitleNonpeptide antagonists for vasopressin receptors. Pharmacology of SR 121463A, a new potent and highly selective V2 receptor antagonist Adv Exp Med Biol 449 427–438 Occurrence Handle10026834 Occurrence Handle1:CAS:528:DC%2BD3cXitVOgu7c%3D

    PubMed  CAS  Google Scholar 

  • K Shimizu (1995) ArticleTitleAquaretic effects of the nonpeptide V2 antagonist OPC-31260 in hydropenic humans Kidney Int 48 220–226 Occurrence Handle7564082 Occurrence Handle10.1038/ki.1995.287 Occurrence Handle1:STN:280:DyaK28%2Fit1ynsg%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • K Shimizu (2003) ArticleTitleCombined effects of vasopressin V2 receptor antagonist and loop diuretic in humans Clin Nephrol 59 164–173 Occurrence Handle12653258 Occurrence Handle1:CAS:528:DC%2BD3sXns1GqtbY%3D

    PubMed  CAS  Google Scholar 

  • A Tosaki M Koltai F Joo G Adam P Szerdahelyi I Lepran I Takats L Szekeres (1985) ArticleTitleActinomycin D suppresses the protective effect of dexamethasone in rats affected by global cerebral ischemia Stroke 16 501–505 Occurrence Handle4002266 Occurrence Handle1:CAS:528:DyaL2MXltlGgtbw%3D

    PubMed  CAS  Google Scholar 

  • Y Tsuboi S Ishikawa G Fujisawa K Okada T Saito (1994a) ArticleTitleIn vivo diuretic effect of a new non-peptide arginine vasopressin antagonist, OPC-31260, in conscious rats J Endocrinol 143 227–234 Occurrence Handle1:CAS:528:DyaK2MXit1ymtr0%3D Occurrence Handle10.1677/joe.0.1430227

    Article  CAS  Google Scholar 

  • Y Tsuboi S Ishikawa G Fujisawa K Okada T Saito (1994b) ArticleTitleTherapeutic efficacy of the non-peptide AVP antagonist OPC-31260 in cirrhotic rats Kidney Int 46 237–244 Occurrence Handle10.1038/ki.1994.265 Occurrence Handle1:CAS:528:DyaK2cXlvFGrtLc%3D

    Article  CAS  Google Scholar 

  • JE Udelson WB Smith GH Hendrix CA Painchaud M Ghazzi I Thomas JK Ghali P Selaru F Chanoine ML Pressler MA Konstam (2001) ArticleTitleAcute haemodynamic effects of conivaptan, a dual V(1A) and V(2) vasopressin receptor antagonist, in patients with advanced heart failure Circulation 104 2417–2423 Occurrence Handle11705818 Occurrence Handle10.1161/hc4501.099313 Occurrence Handle1:CAS:528:DC%2BD3MXpt1KhsL4%3D

    Article  PubMed  CAS  Google Scholar 

  • F Wong AT Blei LM Blendis PJ Thuluvath (2003) ArticleTitleA vasopressin receptor antagonist (VPA-985) improves serum sodium concentration in patients with hyponatremia: a multicenter, randomized, placebo-controlled trial Hepatology 37 182–191 Occurrence Handle12500203 Occurrence Handle10.1053/jhep.2003.50021 Occurrence Handle1:CAS:528:DC%2BD3sXovVWhug%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • M Yamamoto M Shimizu H Okamiya (1990) ArticleTitlePharmacological actions of a new TRH analogue, YM-14673, in rats subjected to cerebral ischaemia and anoxia Eur J Pharmacol 181 207–214 Occurrence Handle2116971 Occurrence Handle10.1016/0014-2999(90)90080-P Occurrence Handle1:CAS:528:DyaK3cXkslWmurg%3D

    Article  PubMed  CAS  Google Scholar 

  • Y Yamamura H Ogawa H Yamashita T Chihara H Miyamoto S Nakamura T Onogawa T Yamashita T Hosokawa T Mori M Tominaga Y Yabuuchi (1992) ArticleTitleCharacterisation of a novel aquaretic agent, OPC-31260, as an orally effective, nonpeptide vasopressin V2 receptor antagonist Br J Pharmacol 105 787–791 Occurrence Handle1387020 Occurrence Handle1:CAS:528:DyaK38XisVyis7o%3D

    PubMed  CAS  Google Scholar 

  • Yamamura Y, Ogawa H, Kondo K, Yamashita H, Chihara T, Nakamura S, Onogawa T, Yamashita T, Yamada Y, Tsujimae K, Mori T, Tominaga M, Yabuuchi Y (1993) Development and pharmacology of non-peptide V1 and V2 vasopressin receptor antagonists. In: Gross P, Richter D, Robertson GL (eds) Vasopressin. John Libbey Eurotext, pp 507–515

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Authors and Affiliations

  1. Department of Comparative Physiology, University of Szeged, Szeged, Hungary

    A. H. Molnár, C. Varga, A. Berkó, I. Rojik & F. A. László

  2. Biological Research Centre, Laboratory of Molecular Neurobiology, Hungarian Academy of Sciences, Szeged, Hungary

    A. Párducz

  3. Institute of Physical Education and Sport Sciences, Faculty of Juhász Gyula Teachers Training College, University of Szeged, Szeged, Hungary

    A. H. Molnár & F. László

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  1. A. H. Molnár
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  2. C. Varga
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  3. A. Berkó
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Correspondence to F. A. László.

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Correspondence: Ferenc A. László, MD, DSc, Department of Comparative Physiology, University of Sciences, Középfasor 52, Szeged H-6726, Hungary.

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Molnár, A., Varga, C., Berkó, A. et al. Inhibitory effect of vasopressin receptor antagonist OPC-31260 on experimental brain oedema induced by global cerebral ischaemia. Acta Neurochir (Wien) 150, 265–271 (2008). https://doi.org/10.1007/s00701-007-1400-1

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